======= ASPM =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ASPM
  * **<color #00a2e8>Official Name</color>**: assembly factor for spindle microtubules
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=259266|259266]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IZT6|Q8IZT6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ASPM&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ASPM|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605481|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CAMSAP CH|
|CH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of asymmetric cell division|
|regulation of asymmetric cell division|
|maintenance of centrosome location|
|spindle assembly involved in meiosis|
|microtubule minus-end|
|forebrain neuroblast division|
|meiotic spindle|
|maintenance of organelle location|
|meiotic spindle organization|
|neuronal stem cell division|
|neuroblast division|
|negative regulation of cell division|
|positive regulation of neuroblast proliferation|
|neuronal stem cell population maintenance|
|somatic stem cell division|
|mitotic spindle pole|
|centrosome localization|
|microtubule organizing center localization|
|neuroblast proliferation|
|regulation of neuroblast proliferation|
|stem cell division|
|positive regulation of stem cell proliferation|
|spindle localization|
|regulation of meiotic cell cycle|
|positive regulation of neural precursor cell proliferation|
|stem cell proliferation|
|regulation of stem cell proliferation|
|forebrain generation of neurons|
|neural precursor cell proliferation|
|oogenesis|
|regulation of neural precursor cell proliferation|
|maintenance of location in cell|
|spindle assembly|
|cerebral cortex development|
|neuron migration|
|female gamete generation|
|male gonad development|
|stem cell population maintenance|
|development of primary male sexual characteristics|
|maintenance of cell number|
|positive regulation of canonical Wnt signaling pathway|
|meiotic nuclear division|
|spindle organization|
|male sex differentiation|
|midbody|
|regulation of reproductive process|
|maintenance of location|
|meiotic cell cycle process|
|regulation of cell division|
|pallium development|
|positive regulation of Wnt signaling pathway|
|calmodulin binding|
|gonad development|
|development of primary sexual characteristics|
|meiotic cell cycle|
|negative regulation of neuron differentiation|
|germ cell development|
|telencephalon development|
|sex differentiation|
|regulation of canonical Wnt signaling pathway|
|nuclear division|
|negative regulation of neurogenesis|
|organelle fission|
|negative regulation of nervous system development|
|apical plasma membrane|
|negative regulation of cell development|
|cellular process involved in reproduction in multicellular organism|
|regulation of Wnt signaling pathway|
|forebrain development|
|developmental growth|
|growth|
|reproductive structure development|
|reproductive system development|
|positive regulation of neurogenesis|
|microtubule cytoskeleton organization|
|centrosome|
|cell division|
|positive regulation of nervous system development|
|positive regulation of cell development|
|spermatogenesis|
|cell population proliferation|
|male gamete generation|
|organelle localization|
|regulation of neuron differentiation|
|developmental process involved in reproduction|
|microtubule-based process|
|gamete generation|
|negative regulation of cell differentiation|
|brain development|
|organelle assembly|
|head development|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cell migration|
|positive regulation of cell differentiation|
|central nervous system development|
|multi-organism reproductive process|
|cell cycle process|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|locomotion|
|cell cycle|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-4.11|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-3.81|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-3.61|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-3.49|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-3.42|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-3.27|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-3.21|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-3.17|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-3.16|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-3.09|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-3.07|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-2.77|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2.71|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.34|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.17|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.1|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-2.07|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.01|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.89|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-1.76|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-1.76|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.75|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dlgap5|DLGAP5]]|0.586|
|[[:human genes:t:tacc3|TACC3]]|0.537|
|[[:human genes:g:gsg2|GSG2]]|0.535|
|[[:human genes:c:calm2|CALM2]]|0.521|
|[[:human genes:k:kif15|KIF15]]|0.456|
|[[:human genes:g:gtse1|GTSE1]]|0.452|
|[[:human genes:g:gak|GAK]]|0.447|
|[[:human genes:s:sephs1|SEPHS1]]|0.436|
|[[:human genes:h:hars|HARS]]|0.425|
|[[:human genes:k:kif18a|KIF18A]]|0.42|
|[[:human genes:d:ddx39a|DDX39A]]|0.416|
|[[:human genes:s:sgol1|SGOL1]]|0.409|
|[[:human genes:m:mcph1|MCPH1]]|0.4|
|[[:human genes:k:klf16|KLF16]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 14/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|3/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6896
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ASPM Expression in NALM6 Cells: 9.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>