======= ASS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ASS1
  * **<color #00a2e8>Official Name</color>**: argininosuccinate synthase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=445|445]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P00966|P00966]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ASS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ASS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603470|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene catalyzes the penultimate step of the arginine biosynthetic pathway. There are approximately 10 to 14 copies of this gene including the pseudogenes scattered across the human genome, among which the one located on chromosome 9 appears to be the only functional gene for argininosuccinate synthetase. Mutations in the chromosome 9 copy of this gene cause citrullinemia. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues. {ECO:0000305|PubMed:18473344, ECO:0000305|PubMed:27287393, ECO:0000305|PubMed:8792870}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arginosuc synth|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|argininosuccinate synthase activity|
|argininosuccinate metabolic process|
|cellular response to amine stimulus|
|cellular response to oleic acid|
|arginine biosynthetic process|
|response to oleic acid|
|citrulline metabolic process|
|cell body fiber|
|response to mycotoxin|
|cellular response to laminar fluid shear stress|
|aspartate metabolic process|
|diaphragm development|
|toxic substance binding|
|urea cycle|
|urea metabolic process|
|nitrogen cycle metabolic process|
|midgut development|
|response to laminar fluid shear stress|
|tricarboxylic acid metabolic process|
|arginine metabolic process|
|amino acid binding|
|cellular response to fluid shear stress|
|glutamine family amino acid biosynthetic process|
|cellular response to glucagon stimulus|
|cellular response to dexamethasone stimulus|
|response to growth hormone|
|response to fluid shear stress|
|response to glucagon|
|positive regulation of nitric oxide biosynthetic process|
|acute-phase response|
|positive regulation of nitric oxide metabolic process|
|response to dexamethasone|
|response to amine|
|positive regulation of reactive oxygen species biosynthetic process|
|aspartate family amino acid metabolic process|
|cellular response to cAMP|
|response to zinc ion|
|cellular response to fatty acid|
|cellular response to glucocorticoid stimulus|
|regulation of nitric oxide biosynthetic process|
|cellular response to corticosteroid stimulus|
|alpha-amino acid biosynthetic process|
|cellular response to amino acid stimulus|
|acute inflammatory response|
|glutamine family amino acid metabolic process|
|cellular amino acid biosynthetic process|
|response to fatty acid|
|regulation of reactive oxygen species biosynthetic process|
|cellular response to ketone|
|response to antineoplastic agent|
|positive regulation of reactive oxygen species metabolic process|
|dicarboxylic acid metabolic process|
|response to cAMP|
|response to amino acid|
|negative regulation of leukocyte cell-cell adhesion|
|liver development|
|hepaticobiliary system development|
|cellular response to ammonium ion|
|digestive tract development|
|skeletal muscle organ development|
|perikaryon|
|response to organophosphorus|
|response to estradiol|
|circadian rhythm|
|digestive system development|
|response to glucocorticoid|
|response to purine-containing compound|
|response to corticosteroid|
|cellular response to interferon-gamma|
|mitochondrial outer membrane|
|negative regulation of cell-cell adhesion|
|regulation of reactive oxygen species metabolic process|
|response to interferon-gamma|
|cellular response to lipopolysaccharide|
|response to ammonium ion|
|cellular response to xenobiotic stimulus|
|cellular response to steroid hormone stimulus|
|cellular response to molecule of bacterial origin|
|response to ketone|
|respiratory system development|
|cellular modified amino acid metabolic process|
|cellular response to acid chemical|
|alpha-amino acid metabolic process|
|response to nutrient|
|cellular response to biotic stimulus|
|cellular response to tumor necrosis factor|
|lysosome|
|response to tumor necrosis factor|
|cellular response to peptide hormone stimulus|
|kidney development|
|negative regulation of cell adhesion|
|rhythmic process|
|aging|
|renal system development|
|muscle organ development|
|regulation of leukocyte cell-cell adhesion|
|response to xenobiotic stimulus|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|response to lipopolysaccharide|
|urogenital system development|
|cellular response to peptide|
|response to molecule of bacterial origin|
|response to steroid hormone|
|response to acid chemical|
|regulation of neurotransmitter levels|
|response to metal ion|
|response to peptide hormone|
|regulation of cell-cell adhesion|
|cellular response to drug|
|gland development|
|response to peptide|
|muscle structure development|
|response to nutrient levels|
|inflammatory response|
|response to toxic substance|
|cellular response to lipid|
|amide biosynthetic process|
|response to extracellular stimulus|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|small molecule biosynthetic process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|regulation of cell adhesion|
|response to bacterium|
|innate immune response|
|cellular amide metabolic process|
|tube development|
|response to lipid|
|carboxylic acid metabolic process|
|response to hormone|
|response to organic cyclic compound|
|defense response to other organism|
|response to organonitrogen compound|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|response to drug|
|organic acid metabolic process|
|cellular response to oxygen-containing compound|
|identical protein binding|
|response to nitrogen compound|
|response to cytokine|
|cellular response to endogenous stimulus|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|RNA binding|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|ATP binding|
|response to oxygen-containing compound|
|cellular nitrogen compound biosynthetic process|
|cellular response to stress|
|small molecule metabolic process|
|immune response|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16420
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ASS1 Expression in NALM6 Cells: 3.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>