======= ASUN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: INTS13
  * **<color #00a2e8>Official Name</color>**: integrator complex subunit 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55726|55726]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NVM9|Q9NVM9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ASUN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ASUN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615079|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing (PubMed:23904267). {ECO:0000269|PubMed:15737938, ECO:0000269|PubMed:23097494, ECO:0000269|PubMed:23904267, ECO:0000305|PubMed:23097494, ECO:0000305|PubMed:23904267}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF2151|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to nuclear envelope|
|regulation of fertilization|
|centrosome localization|
|microtubule organizing center localization|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|flagellated sperm motility|
|sperm motility|
|mitotic spindle organization|
|cilium-dependent cell motility|
|ncRNA transcription|
|cilium or flagellum-dependent cell motility|
|microtubule cytoskeleton organization involved in mitosis|
|spindle organization|
|regulation of reproductive process|
|protein localization to nucleus|
|microtubule cytoskeleton organization|
|transcription by RNA polymerase II|
|cell division|
|organelle localization|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|microtubule-based process|
|mitotic cell cycle|
|protein localization to organelle|
|regulation of multi-organism process|
|cell cycle process|
|cell motility|
|localization of cell|
|nucleobase-containing compound biosynthetic process|
|cytoskeleton organization|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|organic cyclic compound biosynthetic process|
|locomotion|
|cell cycle|
|reproductive process|
|reproduction|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-2.64|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.32|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.3|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.09|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.04|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.94|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.94|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.89|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.87|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.84|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.82|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.82|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.72|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.74|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.76|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.78|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.86|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.89|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.97|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.02|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.04|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.07|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.11|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|2.21|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.23|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.26|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.3|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.35|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|2.36|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.43|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.45|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.54|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.65|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.66|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.7|
|[[:results:exp534|Trientine 500μM R08 exp534]]|2.85|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.95|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.96|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.97|
|[[:results:exp135|MS023 7μM R03 exp135]]|3.07|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|3.2|
|[[:results:exp116|AICAR 240μM R03 exp116]]|3.26|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|3.27|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|3.55|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|3.74|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|3.84|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|4.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:ints10|INTS10]]|0.843|
|[[:human genes:c:c7orf26|C7orf26]]|0.819|
|[[:human genes:v:vwa9|VWA9]]|0.602|
|[[:human genes:u:urm1|URM1]]|0.479|
|[[:human genes:m:mocs3|MOCS3]]|0.471|
|[[:human genes:c:ctu1|CTU1]]|0.455|
|[[:human genes:e:elp3|ELP3]]|0.405|
|[[:human genes:a:acsl3|ACSL3]]|0.403|
|[[:human genes:u:uba5|UBA5]]|0.401|
|[[:human genes:m:mlst8|MLST8]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2425
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ASUN Expression in NALM6 Cells: 5.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>