======= ATF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATF2
  * **<color #00a2e8>Official Name</color>**: activating transcription factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1386|1386]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15336|P15336]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/123811|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|bZIP 2|
|bZIP 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of transforming growth factor beta2 production|
|positive regulation of cardiac muscle myoblast proliferation|
|regulation of cardiac muscle myoblast proliferation|
|regulation of transforming growth factor beta2 production|
|positive regulation of myoblast proliferation|
|cAMP response element binding protein binding|
|response to water deprivation|
|regulation of myoblast proliferation|
|cAMP response element binding|
|intra-S DNA damage checkpoint|
|response to water|
|positive regulation of mitochondrial membrane permeability involved in apoptotic process|
|mitochondrial outer membrane permeabilization involved in programmed cell death|
|positive regulation of transforming growth factor beta production|
|positive regulation of mitochondrial membrane permeability|
|amelogenesis|
|regulation of mitochondrial membrane permeability involved in apoptotic process|
|positive regulation of membrane permeability|
|enhancer sequence-specific DNA binding|
|regulation of transforming growth factor beta production|
|adipose tissue development|
|histone acetyltransferase activity|
|RNA polymerase II activating transcription factor binding|
|positive regulation of neuron apoptotic process|
|site of double-strand break|
|apoptotic mitochondrial changes|
|regulation of mitochondrial membrane permeability|
|outflow tract morphogenesis|
|response to osmotic stress|
|regulation of membrane permeability|
|odontogenesis of dentin-containing tooth|
|positive regulation of neuron death|
|mitotic DNA damage checkpoint|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|negative regulation of angiogenesis|
|mitotic DNA integrity checkpoint|
|negative regulation of blood vessel morphogenesis|
|fat cell differentiation|
|histone acetylation|
|negative regulation of vasculature development|
|internal peptidyl-lysine acetylation|
|odontogenesis|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|negative regulation of epithelial cell proliferation|
|mitochondrial membrane organization|
|DNA damage checkpoint|
|protein acetylation|
|DNA integrity checkpoint|
|mitotic cell cycle checkpoint|
|mitochondrial outer membrane|
|protein acylation|
|cell cycle checkpoint|
|regulation of neuron apoptotic process|
|mitochondrial transport|
|connective tissue development|
|heart morphogenesis|
|positive regulation of DNA-binding transcription factor activity|
|regulation of angiogenesis|
|negative regulation of mitotic cell cycle|
|regulation of neuron death|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|peptidyl-lysine modification|
|regulation of vasculature development|
|regulation of epithelial cell proliferation|
|response to acid chemical|
|histone modification|
|covalent chromatin modification|
|chromatin binding|
|regulation of DNA-binding transcription factor activity|
|mitochondrion organization|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|positive regulation of cytokine production|
|protein kinase binding|
|protein heterodimerization activity|
|heart development|
|response to inorganic substance|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|mitotic cell cycle|
|regulation of cytokine production|
|positive regulation of cell death|
|chromatin organization|
|cellular response to DNA damage stimulus|
|membrane organization|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|apoptotic process|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell cycle process|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|chromosome organization|
|cell death|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of cell death|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.73|
|[[:results:exp303|39°C R06 exp303]]|1.73|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|1.79|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18414
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATF2 Expression in NALM6 Cells: 5.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>