======= ATG13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATG13
  * **<color #00a2e8>Official Name</color>**: autophagy related 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9776|9776]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75143|O75143]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATG13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATG13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615088|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an autophagy factor and a target of the TOR kinase signaling pathway. The encoded protein is essential for autophagosome formation and mitophagy. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1- RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:19211835, ECO:0000269|PubMed:19225151, ECO:0000269|PubMed:19287211, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:21855797}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATG13|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|piecemeal microautophagy of the nucleus|
|lysosomal microautophagy|
|autophagy of nucleus|
|mitophagy|
|Atg1/ULK1 kinase complex|
|protein kinase regulator activity|
|protein localization to phagophore assembly site|
|response to mitochondrial depolarisation|
|selective autophagy|
|phagophore assembly site|
|positive regulation of protein targeting to mitochondrion|
|autophagy of mitochondrion|
|mitochondrion disassembly|
|regulation of protein targeting to mitochondrion|
|positive regulation of establishment of protein localization to mitochondrion|
|autophagosome assembly|
|organelle disassembly|
|extrinsic component of membrane|
|autophagosome organization|
|regulation of establishment of protein localization to mitochondrion|
|regulation of protein targeting|
|positive regulation of mitochondrion organization|
|vacuole organization|
|positive regulation of intracellular protein transport|
|macroautophagy|
|regulation of macroautophagy|
|regulation of mitochondrion organization|
|positive regulation of intracellular transport|
|regulation of intracellular protein transport|
|process utilizing autophagic mechanism|
|autophagy|
|positive regulation of cellular protein localization|
|activation of protein kinase activity|
|regulation of autophagy|
|regulation of intracellular transport|
|cellular component disassembly|
|positive regulation of protein transport|
|mitochondrion organization|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|positive regulation of protein kinase activity|
|regulation of cellular protein localization|
|positive regulation of kinase activity|
|positive regulation of organelle organization|
|positive regulation of transferase activity|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|organelle assembly|
|regulation of protein kinase activity|
|regulation of cellular catabolic process|
|regulation of kinase activity|
|regulation of cellular localization|
|endoplasmic reticulum membrane|
|regulation of transferase activity|
|positive regulation of transport|
|regulation of catabolic process|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|positive regulation of phosphorylation|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|mitochondrion|
|regulation of organelle organization|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-1.85|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4684
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATG13 Expression in NALM6 Cells: 5.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>