======= ATG7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATG7
  * **<color #00a2e8>Official Name</color>**: autophagy related 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10533|10533]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95352|O95352]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATG7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATG7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608760|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E1-like activating enzyme involved in the 2 ubiquitin- like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. {ECO:0000269|PubMed:11096062, ECO:0000269|PubMed:16303767, ECO:0000269|PubMed:22170151}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ThiF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Atg12 activating enzyme activity|
|negative regulation by symbiont of host autophagy|
|Atg8 activating enzyme activity|
|suppression by virus of host autophagy|
|negative regulation of mitochondrial DNA replication|
|modulation by virus of host autophagy|
|regulation of mitochondrial DNA replication|
|late nucleophagy|
|piecemeal microautophagy of the nucleus|
|regulation of autophagic cell death|
|lysosomal microautophagy|
|ubiquitin activating enzyme activity|
|cellular response to morphine|
|cellular response to isoquinoline alkaloid|
|autophagy of nucleus|
|response to fluoride|
|positive regulation by symbiont of host autophagy|
|modulation by symbiont of host autophagy|
|C-terminal protein lipidation|
|cellular response to hyperoxia|
|modulation by symbiont of host programmed cell death|
|chaperone-mediated autophagy|
|cellular response to nitrogen levels|
|cellular response to nitrogen starvation|
|cellular response to increased oxygen levels|
|C-terminal protein amino acid modification|
|modulation by virus of host cellular process|
|negative regulation of oxidative stress-induced neuron death|
|response to hyperoxia|
|negative regulation of DNA-dependent DNA replication|
|phagophore assembly site|
|regulation of oxidative stress-induced neuron death|
|modulation by symbiont of host cellular process|
|response to increased oxygen levels|
|modulation by virus of host morphology or physiology|
|response to morphine|
|response to isoquinoline alkaloid|
|cellular response to alkaloid|
|autophagy of mitochondrion|
|mitochondrion disassembly|
|negative regulation of DNA replication|
|modification by symbiont of host morphology or physiology|
|negative regulation of oxidative stress-induced cell death|
|negative regulation of cellular response to oxidative stress|
|negative regulation of response to oxidative stress|
|regulation of DNA-dependent DNA replication|
|autophagosome assembly|
|regulation of oxidative stress-induced cell death|
|organelle disassembly|
|autophagosome organization|
|regulation of cellular response to oxidative stress|
|response to anesthetic|
|negative regulation of autophagy|
|regulation of response to oxidative stress|
|protein lipidation|
|lipoprotein biosynthetic process|
|axoneme|
|regulation of DNA replication|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|response to alkaloid|
|regulation of circadian rhythm|
|secretory granule lumen|
|lipoprotein metabolic process|
|positive regulation of autophagy|
|ficolin-1-rich granule lumen|
|cellular response to ammonium ion|
|vacuole organization|
|membrane fusion|
|response to glucose|
|response to hexose|
|response to monosaccharide|
|cellular response to starvation|
|modification of morphology or physiology of other organism|
|interaction with host|
|macroautophagy|
|response to carbohydrate|
|response to ammonium ion|
|cellular response to xenobiotic stimulus|
|defense response to virus|
|response to starvation|
|negative regulation of neuron death|
|cellular response to oxygen levels|
|positive regulation of protein catabolic process|
|cellular response to nutrient levels|
|negative regulation of cellular catabolic process|
|process utilizing autophagic mechanism|
|autophagy|
|cellular response to extracellular stimulus|
|rhythmic process|
|aging|
|response to virus|
|axon|
|response to xenobiotic stimulus|
|negative regulation of catabolic process|
|regulation of neuron death|
|regulation of autophagy|
|transcription factor binding|
|cellular response to external stimulus|
|response to acid chemical|
|post-translational protein modification|
|positive regulation of cellular catabolic process|
|response to oxygen levels|
|regulation of protein catabolic process|
|cellular component disassembly|
|cellular response to drug|
|positive regulation of catabolic process|
|mitochondrion organization|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|response to nutrient levels|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|response to extracellular stimulus|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|myeloid leukocyte activation|
|cellular response to organonitrogen compound|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|cellular response to nitrogen compound|
|protein catabolic process|
|protein ubiquitination|
|positive regulation of cell death|
|viral process|
|regulated exocytosis|
|regulation of cellular response to stress|
|organelle assembly|
|leukocyte mediated immunity|
|protein modification by small protein conjugation|
|symbiotic process|
|exocytosis|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|membrane organization|
|protein homodimerization activity|
|response to organic cyclic compound|
|leukocyte activation|
|defense response to other organism|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|negative regulation of cell death|
|response to organonitrogen compound|
|secretion by cell|
|response to drug|
|export from cell|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|secretion|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|organonitrogen compound biosynthetic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|protein transport|
|negative regulation of cellular biosynthetic process|
|peptide transport|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|negative regulation of response to stimulus|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|nitrogen compound transport|
|regulation of protein modification process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7766
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATG7 Expression in NALM6 Cells: 4.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>