======= ATMIN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATMIN
  * **<color #00a2e8>Official Name</color>**: ATM interactor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23300|23300]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43313|O43313]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATMIN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATMIN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614693|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription. {ECO:0000269|PubMed:15933716, ECO:0000269|PubMed:17525732, ECO:0000269|PubMed:22167198}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of non-motile cilium assembly|
|regulation of non-motile cilium assembly|
|dynein complex binding|
|motile cilium assembly|
|positive regulation of cilium assembly|
|positive regulation of organelle assembly|
|regulation of cilium assembly|
|positive regulation of plasma membrane bounded cell projection assembly|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|transcription regulatory region DNA binding|
|regulation of organelle assembly|
|nuclear body|
|cilium assembly|
|cilium organization|
|positive regulation of cell projection organization|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|positive regulation of cellular component biogenesis|
|positive regulation of organelle organization|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|organelle assembly|
|cellular response to DNA damage stimulus|
|regulation of cellular component biogenesis|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.24|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.21|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.72|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.72|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.74|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.75|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.79|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.87|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.93|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.96|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|2|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.05|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.06|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.06|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.16|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.23|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.24|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.29|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.36|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.48|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.9|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|3.03|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|3.4|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|4.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dynll1|DYNLL1]]|0.683|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6635
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATMIN Expression in NALM6 Cells: 6.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>