======= ATOH1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATOH1
  * **<color #00a2e8>Official Name</color>**: atonal bHLH transcription factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=474|474]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92858|Q92858]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATOH1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATOH1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601461|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|auditory receptor cell fate determination|
|auditory receptor cell fate specification|
|positive regulation of inner ear receptor cell differentiation|
|positive regulation of inner ear auditory receptor cell differentiation|
|positive regulation of mechanoreceptor differentiation|
|positive regulation of neuroepithelial cell differentiation|
|auditory receptor cell fate commitment|
|inner ear receptor cell fate commitment|
|neuron fate determination|
|regulation of inner ear auditory receptor cell differentiation|
|regulation of inner ear receptor cell differentiation|
|regulation of mechanoreceptor differentiation|
|epithelial cell fate commitment|
|positive regulation of epidermal cell differentiation|
|inner ear auditory receptor cell differentiation|
|neuron fate specification|
|hair cell differentiation|
|cell fate determination|
|positive regulation of epidermis development|
|neuroepithelial cell differentiation|
|inner ear receptor cell differentiation|
|mechanoreceptor differentiation|
|positive regulation of epithelial cell differentiation|
|regulation of epidermal cell differentiation|
|neuron fate commitment|
|chromatin DNA binding|
|regulation of epidermis development|
|cell fate specification|
|columnar/cuboidal epithelial cell differentiation|
|inner ear morphogenesis|
|cerebral cortex development|
|ear morphogenesis|
|neuron migration|
|Notch signaling pathway|
|regulation of epithelial cell differentiation|
|protein dimerization activity|
|pallium development|
|inner ear development|
|ear development|
|cell fate commitment|
|sensory organ morphogenesis|
|telencephalon development|
|axon guidance|
|neuron projection guidance|
|embryonic organ morphogenesis|
|epidermal cell differentiation|
|positive regulation of neuron differentiation|
|axonogenesis|
|forebrain development|
|axon development|
|epidermis development|
|cell morphogenesis involved in neuron differentiation|
|embryonic organ development|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|transcription by RNA polymerase II|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cell part morphogenesis|
|positive regulation of nervous system development|
|positive regulation of cell development|
|sensory organ development|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|embryonic morphogenesis|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|regulation of neuron differentiation|
|neuron projection development|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|negative regulation of cell death|
|neuron differentiation|
|cell motility|
|localization of cell|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|organic cyclic compound biosynthetic process|
|locomotion|
|positive regulation of developmental process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|1.8|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11980
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATOH1 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>