======= ATP2B1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP2B1
  * **<color #00a2e8>Official Name</color>**: ATPase plasma membrane Ca2+ transporting 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=490|490]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20020|P20020]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP2B1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP2B1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/108731|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|E1-E2 ATPase|
|Cation ATPase N|
|HAD|
|Cation ATPase C|
|Hydrolase|
|ATP Ca trans C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration|
|cellular response to corticosterone stimulus|
|calcium ion transmembrane transporter activity|
|calcium ion export across plasma membrane|
|cellular response to mineralocorticoid stimulus|
|calcium ion export|
|regulation of vascular smooth muscle contraction|
|calcium transmembrane transporter activity, phosphorylative mechanism|
|negative regulation of cytosolic calcium ion concentration|
|dendritic spine membrane|
|cellular response to vitamin D|
|integral component of presynaptic active zone membrane|
|regulation of presynaptic cytosolic calcium ion concentration|
|response to corticosterone|
|cellular response to vitamin|
|neuronal cell body membrane|
|response to vitamin D|
|response to mineralocorticoid|
|neuron cellular homeostasis|
|immunological synapse|
|export across plasma membrane|
|positive regulation of bone mineralization|
|positive regulation of biomineralization|
|positive regulation of biomineral tissue development|
|response to cold|
|cytoplasmic side of plasma membrane|
|cellular response to glucocorticoid stimulus|
|regulation of vasoconstriction|
|neural retina development|
|cellular response to corticosteroid stimulus|
|regulation of smooth muscle contraction|
|GABA-ergic synapse|
|cellular response to nutrient|
|regulation of cardiac conduction|
|regulation of cellular response to insulin stimulus|
|regulation of bone mineralization|
|cellular response to alcohol|
|positive regulation of ossification|
|response to vitamin|
|PDZ domain binding|
|cytosolic calcium ion transport|
|cellular response to ketone|
|regulation of biomineralization|
|regulation of biomineral tissue development|
|positive regulation of calcium ion transport|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|retina development in camera-type eye|
|response to glucocorticoid|
|regulation of muscle contraction|
|response to corticosteroid|
|vascular process in circulatory system|
|response to temperature stimulus|
|regulation of blood pressure|
|cellular response to steroid hormone stimulus|
|regulation of ossification|
|response to ketone|
|basolateral plasma membrane|
|calcium ion transmembrane transport|
|calmodulin binding|
|response to nutrient|
|membrane raft|
|response to alcohol|
|cellular response to nutrient levels|
|ATPase activity|
|regulation of muscle system process|
|regulation of heart contraction|
|regulation of calcium ion transport|
|calcium ion transport|
|cellular response to extracellular stimulus|
|negative regulation of cytokine production|
|positive regulation of ion transport|
|aging|
|regulation of blood circulation|
|divalent metal ion transport|
|divalent inorganic cation transport|
|camera-type eye development|
|apical plasma membrane|
|regulation of cytosolic calcium ion concentration|
|response to steroid hormone|
|cellular response to external stimulus|
|anatomical structure homeostasis|
|glutamatergic synapse|
|eye development|
|visual system development|
|sensory system development|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|response to nutrient levels|
|regulation of anatomical structure size|
|cellular response to lipid|
|response to extracellular stimulus|
|cellular response to organic cyclic compound|
|sensory organ development|
|cell junction|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of system process|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|regulation of cytokine production|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|brain development|
|cellular chemical homeostasis|
|head development|
|ion homeostasis|
|cation transport|
|response to lipid|
|cellular homeostasis|
|response to hormone|
|response to organic cyclic compound|
|ion transmembrane transport|
|central nervous system development|
|positive regulation of transport|
|export from cell|
|cellular response to oxygen-containing compound|
|chemical homeostasis|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|transmembrane transport|
|positive regulation of developmental process|
|ion transport|
|integral component of plasma membrane|
|response to endogenous stimulus|
|ATP binding|
|response to oxygen-containing compound|
|homeostatic process|
|positive regulation of multicellular organismal process|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-3.62|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-3.52|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-3.33|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.88|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.66|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.59|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-2.58|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-2.52|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-2.49|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2.32|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-2.25|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-2.24|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-2.21|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.21|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-2.2|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-2.19|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.17|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.14|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.13|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-2.12|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.08|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.08|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-2.04|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-2.03|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-2.02|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.01|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-1.96|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.96|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-1.96|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-1.89|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-1.87|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.8|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-1.8|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-1.8|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.79|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.78|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.77|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.77|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.77|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|-1.75|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-1.75|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.74|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-1.72|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.71|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|1.72|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|1.74|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.74|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.78|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.79|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.86|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.88|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|1.93|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.97|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|2.02|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.04|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.06|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.07|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.1|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.2|
|[[:results:exp461|BS-181 20μM R08 exp461]]|2.25|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.28|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.32|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.33|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.6|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|2.62|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.75|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.81|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.99|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|3.23|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|3.4|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|3.59|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|3.59|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|3.86|
|[[:results:exp504|MK2206 4μM R08 exp504]]|4|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|4.17|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|4.53|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|4.75|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|8.44|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:urm1|URM1]]|0.424|
|[[:human genes:d:ddx39a|DDX39A]]|0.419|
|[[:human genes:r:rbbp4|RBBP4]]|0.408|
|[[:human genes:c:c16orf80|C16orf80]]|0.408|
|[[:human genes:k:kctd5|KCTD5]]|0.405|
|[[:human genes:n:n6amt1|N6AMT1]]|0.402|
|[[:human genes:d:ddx1|DDX1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14652
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP2B1 Expression in NALM6 Cells: 7.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>