======= ATP2B2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP2B2
  * **<color #00a2e8>Official Name</color>**: ATPase plasma membrane Ca2+ transporting 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=491|491]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01814|Q01814]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP2B2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP2B2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/108733|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hydrolase|
|ATP Ca trans C|
|HAD|
|Cation ATPase C|
|E1-E2 ATPase|
|Cation ATPase N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration|
|calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration|
|calcium transmembrane transporter activity, phosphorylative mechanism|
|regulation of postsynaptic cytosolic calcium ion concentration|
|regulation of presynaptic cytosolic calcium ion concentration|
|postsynaptic density membrane|
|neuron cellular homeostasis|
|GABA-ergic synapse|
|regulation of cardiac conduction|
|PDZ domain binding|
|presynapse|
|sensory perception of sound|
|sensory perception of mechanical stimulus|
|calcium ion transmembrane transport|
|calmodulin binding|
|regulation of heart contraction|
|calcium ion transport|
|regulation of blood circulation|
|divalent metal ion transport|
|divalent inorganic cation transport|
|regulation of cytosolic calcium ion concentration|
|anatomical structure homeostasis|
|glutamatergic synapse|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|cell junction|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of system process|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|ion transmembrane transport|
|sensory perception|
|neuron differentiation|
|chemical homeostasis|
|transmembrane transport|
|ion transport|
|nervous system process|
|ATP binding|
|generation of neurons|
|neurogenesis|
|homeostatic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.92|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.71|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.8|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|1.83|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5013
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP2B2 Expression in NALM6 Cells: 0.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>