======= ATP2B4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP2B4
  * **<color #00a2e8>Official Name</color>**: ATPase plasma membrane Ca2+ transporting 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=493|493]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23634|P23634]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP2B4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP2B4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/108732|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). {ECO:0000250|UniProtKB:Q6Q477, ECO:0000269|PubMed:8530416}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|E1-E2 ATPase|
|Cation ATPase N|
|HAD|
|Cation ATPase C|
|Hydrolase|
|ATP Ca trans C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of citrulline biosynthetic process|
|regulation of citrulline biosynthetic process|
|regulation of cellular amine catabolic process|
|nitric-oxide synthase inhibitor activity|
|negative regulation of the force of heart contraction|
|negative regulation of cellular amine catabolic process|
|negative regulation of arginine catabolic process|
|regulation of arginine catabolic process|
|negative regulation of cellular amino acid biosynthetic process|
|negative regulation of cellular amino acid metabolic process|
|negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process|
|regulation of cellular amino acid biosynthetic process|
|regulation of arginine metabolic process|
|negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway|
|negative regulation of nitric oxide mediated signal transduction|
|regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process|
|negative regulation of peptidyl-cysteine S-nitrosylation|
|positive regulation of cAMP-dependent protein kinase activity|
|response to hydrostatic pressure|
|negative regulation of cellular amine metabolic process|
|regulation of glutamine family amino acid metabolic process|
|negative regulation of cardiac muscle hypertrophy in response to stress|
|negative regulation of cardiac muscle adaptation|
|calcium ion export|
|urinary bladder smooth muscle contraction|
|negative regulation of nitric-oxide synthase activity|
|protein phosphatase 2B binding|
|urinary tract smooth muscle contraction|
|regulation of peptidyl-cysteine S-nitrosylation|
|negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|regulation of cardiac muscle adaptation|
|regulation of cardiac muscle hypertrophy in response to stress|
|calcium ion import across plasma membrane|
|calcium ion import into cytosol|
|calcium transmembrane transporter activity, phosphorylative mechanism|
|regulation of nitric oxide mediated signal transduction|
|negative regulation of muscle adaptation|
|negative regulation of monooxygenase activity|
|regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|cellular response to epinephrine stimulus|
|negative regulation of calcineurin-mediated signaling|
|negative regulation of nitric oxide biosynthetic process|
|nitric-oxide synthase binding|
|negative regulation of calcineurin-NFAT signaling cascade|
|negative regulation of nitric oxide metabolic process|
|integral component of presynaptic active zone membrane|
|response to water|
|regulation of cAMP-dependent protein kinase activity|
|response to epinephrine|
|sperm principal piece|
|negative regulation of cAMP-mediated signaling|
|negative regulation of oxidoreductase activity|
|negative regulation of cardiac muscle hypertrophy|
|negative regulation of reactive oxygen species biosynthetic process|
|regulation of the force of heart contraction|
|negative regulation of muscle hypertrophy|
|negative regulation of calcium-mediated signaling|
|response to acetylcholine|
|cellular response to acetylcholine|
|regulation of calcineurin-mediated signaling|
|regulation of calcineurin-NFAT signaling cascade|
|sodium channel regulator activity|
|T-tubule|
|calcium ion import|
|sperm flagellum|
|regulation of nitric-oxide synthase activity|
|negative regulation of G protein-coupled receptor signaling pathway|
|regulation of cAMP-mediated signaling|
|smooth muscle contraction|
|negative regulation of reactive oxygen species metabolic process|
|regulation of monooxygenase activity|
|regulation of cardiac muscle hypertrophy|
|regulation of nitric oxide biosynthetic process|
|neural retina development|
|regulation of muscle hypertrophy|
|scaffold protein binding|
|regulation of cellular amino acid metabolic process|
|regulation of sodium ion transmembrane transport|
|calcium ion transmembrane import into cytosol|
|regulation of cardiac conduction|
|flagellated sperm motility|
|sperm motility|
|calcium ion transport into cytosol|
|caveola|
|inorganic cation import across plasma membrane|
|inorganic ion import across plasma membrane|
|regulation of cellular amine metabolic process|
|hippocampus development|
|regulation of muscle adaptation|
|regulation of reactive oxygen species biosynthetic process|
|regulation of sodium ion transport|
|PDZ domain binding|
|cytosolic calcium ion transport|
|negative regulation of small molecule metabolic process|
|cilium-dependent cell motility|
|cilium or flagellum-dependent cell motility|
|regulation of oxidoreductase activity|
|regulation of calcium-mediated signaling|
|import across plasma membrane|
|cellular response to catecholamine stimulus|
|cellular response to monoamine stimulus|
|positive regulation of peptidyl-serine phosphorylation|
|response to catecholamine|
|response to monoamine|
|limbic system development|
|cellular response to ammonium ion|
|Z disc|
|regulation of peptidyl-serine phosphorylation|
|retina development in camera-type eye|
|regulation of G protein-coupled receptor signaling pathway|
|regulation of cell cycle G1/S phase transition|
|regulation of cellular ketone metabolic process|
|pallium development|
|regulation of reactive oxygen species metabolic process|
|response to ammonium ion|
|basolateral plasma membrane|
|calcium ion transmembrane transport|
|calmodulin binding|
|regulation of muscle system process|
|regulation of heart contraction|
|calcium ion transport|
|muscle contraction|
|negative regulation of cellular catabolic process|
|telencephalon development|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|divalent metal ion transport|
|muscle system process|
|divalent inorganic cation transport|
|negative regulation of catabolic process|
|camera-type eye development|
|neuron projection|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|positive regulation of protein serine/threonine kinase activity|
|response to acid chemical|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|eye development|
|visual system development|
|sensory system development|
|forebrain development|
|regulation of metal ion transport|
|cellular response to drug|
|regulation of small molecule metabolic process|
|cellular calcium ion homeostasis|
|regulation of cell cycle phase transition|
|calcium ion homeostasis|
|protein kinase binding|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|divalent inorganic cation homeostasis|
|negative regulation of intracellular signal transduction|
|regulation of protein serine/threonine kinase activity|
|response to inorganic substance|
|positive regulation of protein kinase activity|
|cellular response to organic cyclic compound|
|spermatogenesis|
|sensory organ development|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|male gamete generation|
|positive regulation of kinase activity|
|regulation of system process|
|negative regulation of protein modification process|
|protein-containing complex|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|import into cell|
|gamete generation|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|brain development|
|cellular chemical homeostasis|
|regulation of cell cycle process|
|head development|
|ion homeostasis|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|multicellular organismal reproductive process|
|cation transport|
|sexual reproduction|
|regulation of cellular catabolic process|
|multicellular organism reproduction|
|regulation of kinase activity|
|cellular homeostasis|
|response to hormone|
|response to organic cyclic compound|
|ion transmembrane transport|
|regulation of transferase activity|
|central nervous system development|
|regulation of catabolic process|
|multi-organism reproductive process|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|response to drug|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|transmembrane transport|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-1.77|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.81|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.455|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10490
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP2B4 Expression in NALM6 Cells: 5.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>