======= ATP5A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP5F1A
  * **<color #00a2e8>Official Name</color>**: ATP synthase F1 subunit alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=498|498]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P25705|P25705]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP5A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP5A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164360|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the alpha subunit of the catalytic core. Alternatively spliced transcript variants encoding the different isoforms have been identified. Pseudogenes of this gene are located on chromosomes 9, 2, and 16. [provided by RefSeq, Mar 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATP-synt ab|
|ATP-synt ab C|
|ATP-synt ab N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proton-transporting ATP synthase complex|
|angiostatin binding|
|mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)|
|mitochondrial proton-transporting ATP synthase complex|
|proton-transporting ATP synthase activity, rotational mechanism|
|MHC class I protein binding|
|mitochondrial ATP synthesis coupled proton transport|
|energy coupled proton transport, down electrochemical gradient|
|ATP synthesis coupled proton transport|
|cristae formation|
|ATP biosynthetic process|
|COP9 signalosome|
|negative regulation of endothelial cell proliferation|
|ADP binding|
|inner mitochondrial membrane organization|
|purine ribonucleoside triphosphate biosynthetic process|
|purine nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate biosynthetic process|
|positive regulation of blood vessel endothelial cell migration|
|purine ribonucleoside triphosphate metabolic process|
|transmembrane transporter activity|
|nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|regulation of blood vessel endothelial cell migration|
|mitochondrial transmembrane transport|
|nucleoside triphosphate metabolic process|
|positive regulation of endothelial cell migration|
|oxidative phosphorylation|
|negative regulation of epithelial cell proliferation|
|mitochondrial membrane organization|
|regulation of endothelial cell proliferation|
|positive regulation of epithelial cell migration|
|proton transmembrane transport|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|regulation of endothelial cell migration|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|ATP metabolic process|
|mitochondrial transport|
|regulation of epithelial cell migration|
|ATPase activity|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|regulation of epithelial cell proliferation|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|mitochondrial matrix|
|mitochondrial inner membrane|
|monovalent inorganic cation transport|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|positive regulation of cell migration|
|drug metabolic process|
|positive regulation of cell motility|
|organophosphate biosynthetic process|
|positive regulation of cellular component movement|
|nucleobase-containing small molecule metabolic process|
|positive regulation of locomotion|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|carbohydrate derivative biosynthetic process|
|inorganic ion transmembrane transport|
|negative regulation of cell population proliferation|
|cation transport|
|regulation of cell migration|
|membrane organization|
|organophosphate metabolic process|
|regulation of cell motility|
|ion transmembrane transport|
|regulation of locomotion|
|regulation of cellular component movement|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|lipid metabolic process|
|mitochondrion|
|transmembrane transport|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|ion transport|
|RNA binding|
|organonitrogen compound biosynthetic process|
|ATP binding|
|intracellular transport|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|establishment of localization in cell|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp318|ABT-702 5μM R07 exp318]]|-2.15|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-1.84|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.78|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-1.75|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-1.71|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.7|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.71|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.71|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.78|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.81|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.81|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.85|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.86|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.86|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.87|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.94|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.02|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.17|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.18|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|2.19|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.2|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.27|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.29|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.32|
|[[:results:exp539|42°C R08 exp539]]|2.36|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|2.44|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.45|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.48|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.5|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.61|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.62|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.67|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.68|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.74|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.79|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.8|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.81|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.89|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|3.06|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|3.35|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|3.48|
|[[:results:exp275|Citral 75μM R06 exp275]]|3.69|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp5b|ATP5B]]|0.782|
|[[:human genes:a:atp5d|ATP5D]]|0.776|
|[[:human genes:a:atp5o|ATP5O]]|0.764|
|[[:human genes:a:atp5c1|ATP5C1]]|0.693|
|[[:human genes:a:atp5l|ATP5L]]|0.644|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.586|
|[[:human genes:a:atp5h|ATP5H]]|0.582|
|[[:human genes:a:atp5f1|ATP5F1]]|0.581|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.579|
|[[:human genes:m:mrpl21|MRPL21]]|0.578|
|[[:human genes:y:yars2|YARS2]]|0.571|
|[[:human genes:a:atp5j|ATP5J]]|0.571|
|[[:human genes:b:bcs1l|BCS1L]]|0.568|
|[[:human genes:w:wbscr16|WBSCR16]]|0.565|
|[[:human genes:a:atp5e|ATP5E]]|0.562|
|[[:human genes:t:tmem242|TMEM242]]|0.561|
|[[:human genes:m:mrps14|MRPS14]]|0.56|
|[[:human genes:t:triap1|TRIAP1]]|0.555|
|[[:human genes:p:ppa2|PPA2]]|0.55|
|[[:human genes:a:atp5j2|ATP5J2]]|0.549|
|[[:human genes:d:dap3|DAP3]]|0.548|
|[[:human genes:u:ube2g2|UBE2G2]]|0.54|
|[[:human genes:s:slc25a26|SLC25A26]]|0.538|
|[[:human genes:a:atp5i|ATP5I]]|0.537|
|[[:human genes:p:pars2|PARS2]]|0.533|
|[[:human genes:o:opa1|OPA1]]|0.532|
|[[:human genes:d:dohh|DOHH]]|0.529|
|[[:human genes:f:fh|FH]]|0.527|
|[[:human genes:m:mrps6|MRPS6]]|0.526|
|[[:human genes:r:romo1|ROMO1]]|0.526|
|[[:human genes:c:cox16|COX16]]|0.522|
|[[:human genes:t:taz|TAZ]]|0.518|
|[[:human genes:m:mrpl23|MRPL23]]|0.516|
|[[:human genes:p:pnpt1|PNPT1]]|0.516|
|[[:human genes:s:sco2|SCO2]]|0.514|
|[[:human genes:d:dars2|DARS2]]|0.514|
|[[:human genes:h:hspd1|HSPD1]]|0.513|
|[[:human genes:t:tars2|TARS2]]|0.509|
|[[:human genes:g:gatc|GATC]]|0.508|
|[[:human genes:m:mrps11|MRPS11]]|0.505|
|[[:human genes:m:mrp63|MRP63]]|0.504|
|[[:human genes:m:mrps26|MRPS26]]|0.503|
|[[:human genes:m:mrpl47|MRPL47]]|0.503|
|[[:human genes:t:thg1l|THG1L]]|0.502|
|[[:human genes:p:pmm2|PMM2]]|0.5|
|[[:human genes:u:uap1|UAP1]]|0.499|
|[[:human genes:g:gfm1|GFM1]]|0.499|
|[[:human genes:m:mrps21|MRPS21]]|0.499|
|[[:human genes:m:mrps16|MRPS16]]|0.497|
|[[:human genes:h:hccs|HCCS]]|0.494|
|[[:human genes:m:mbtps2|MBTPS2]]|0.491|
|[[:human genes:a:alg6|ALG6]]|0.491|
|[[:human genes:t:tefm|TEFM]]|0.491|
|[[:human genes:d:dnlz|DNLZ]]|0.49|
|[[:human genes:s:selrc1|SELRC1]]|0.484|
|[[:human genes:v:vars2|VARS2]]|0.484|
|[[:human genes:t:tamm41|TAMM41]]|0.483|
|[[:human genes:a:alg5|ALG5]]|0.483|
|[[:human genes:d:dhrsx|DHRSX]]|0.483|
|[[:human genes:c:cox7b|COX7B]]|0.482|
|[[:human genes:h:hars2|HARS2]]|0.478|
|[[:human genes:a:atxn10|ATXN10]]|0.478|
|[[:human genes:e:elac2|ELAC2]]|0.477|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.477|
|[[:human genes:f:fastkd5|FASTKD5]]|0.474|
|[[:human genes:a:adsl|ADSL]]|0.474|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.473|
|[[:human genes:c:cycs|CYCS]]|0.471|
|[[:human genes:s:ssb|SSB]]|0.47|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.47|
|[[:human genes:r:rars2|RARS2]]|0.47|
|[[:human genes:p:pgm3|PGM3]]|0.47|
|[[:human genes:g:gfpt1|GFPT1]]|0.468|
|[[:human genes:u:uba5|UBA5]]|0.467|
|[[:human genes:m:mrps18a|MRPS18A]]|0.467|
|[[:human genes:s:slc25a3|SLC25A3]]|0.464|
|[[:human genes:n:ndufa3|NDUFA3]]|0.464|
|[[:human genes:t:tmem41b|TMEM41B]]|0.463|
|[[:human genes:t:tufm|TUFM]]|0.462|
|[[:human genes:m:mrps34|MRPS34]]|0.461|
|[[:human genes:s:sars2|SARS2]]|0.46|
|[[:human genes:n:nars2|NARS2]]|0.456|
|[[:human genes:p:pgs1|PGS1]]|0.455|
|[[:human genes:e:ears2|EARS2]]|0.454|
|[[:human genes:c:c10orf2|C10orf2]]|0.454|
|[[:human genes:d:dpagt1|DPAGT1]]|0.453|
|[[:human genes:k:kdsr|KDSR]]|0.453|
|[[:human genes:c:casp9|CASP9]]|0.452|
|[[:human genes:n:ndufc2|NDUFC2]]|0.451|
|[[:human genes:p:pdss1|PDSS1]]|0.45|
|[[:human genes:m:mrps23|MRPS23]]|0.45|
|[[:human genes:m:mrpl20|MRPL20]]|0.449|
|[[:human genes:m:mrpl53|MRPL53]]|0.448|
|[[:human genes:m:mrps5|MRPS5]]|0.447|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.446|
|[[:human genes:c:c17orf89|C17orf89]]|0.446|
|[[:human genes:c:cbfb|CBFB]]|0.445|
|[[:human genes:q:qrsl1|QRSL1]]|0.444|
|[[:human genes:e:eny2|ENY2]]|0.443|
|[[:human genes:c:cept1|CEPT1]]|0.442|
|[[:human genes:u:urm1|URM1]]|0.442|
|[[:human genes:c:cox15|COX15]]|0.442|
|[[:human genes:r:rpp21|RPP21]]|0.441|
|[[:human genes:c:crls1|CRLS1]]|0.44|
|[[:human genes:f:faf2|FAF2]]|0.44|
|[[:human genes:h:hist1h2bk|HIST1H2BK]]|0.439|
|[[:human genes:r:rbfa|RBFA]]|0.438|
|[[:human genes:l:lars2|LARS2]]|0.437|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.436|
|[[:human genes:n:ndufb5|NDUFB5]]|0.435|
|[[:human genes:a:alg1|ALG1]]|0.435|
|[[:human genes:s:sec62|SEC62]]|0.433|
|[[:human genes:c:c14orf2|C14orf2]]|0.433|
|[[:human genes:n:ndufb1|NDUFB1]]|0.431|
|[[:human genes:m:mrps33|MRPS33]]|0.431|
|[[:human genes:m:mrpl15|MRPL15]]|0.43|
|[[:human genes:a:apaf1|APAF1]]|0.43|
|[[:human genes:s:slc25a52|SLC25A52]]|0.429|
|[[:human genes:v:vezt|VEZT]]|0.428|
|[[:human genes:m:mrps10|MRPS10]]|0.425|
|[[:human genes:m:mrpl41|MRPL41]]|0.425|
|[[:human genes:s:sdha|SDHA]]|0.425|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.424|
|[[:human genes:n:ndufb3|NDUFB3]]|0.424|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.424|
|[[:human genes:p:plaa|PLAA]]|0.424|
|[[:human genes:p:pggt1b|PGGT1B]]|0.423|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.423|
|[[:human genes:p:ppcs|PPCS]]|0.423|
|[[:human genes:n:ndufa1|NDUFA1]]|0.423|
|[[:human genes:r:rpe|RPE]]|0.422|
|[[:human genes:n:ndufb11|NDUFB11]]|0.422|
|[[:human genes:c:c1orf27|C1orf27]]|0.422|
|[[:human genes:e:exoc4|EXOC4]]|0.422|
|[[:human genes:m:mrps9|MRPS9]]|0.421|
|[[:human genes:d:dolk|DOLK]]|0.421|
|[[:human genes:r:rpusd4|RPUSD4]]|0.421|
|[[:human genes:t:timm13|TIMM13]]|0.421|
|[[:human genes:e:elp3|ELP3]]|0.42|
|[[:human genes:b:bak1|BAK1]]|0.42|
|[[:human genes:d:dnajc3|DNAJC3]]|0.419|
|[[:human genes:l:lsm11|LSM11]]|0.419|
|[[:human genes:m:mrps25|MRPS25]]|0.417|
|[[:human genes:m:mars2|MARS2]]|0.416|
|[[:human genes:p:ppp6c|PPP6C]]|0.416|
|[[:human genes:g:gmppb|GMPPB]]|0.414|
|[[:human genes:t:trnt1|TRNT1]]|0.413|
|[[:human genes:s:srp14|SRP14]]|0.411|
|[[:human genes:r:rptor|RPTOR]]|0.411|
|[[:human genes:e:eif3f|EIF3F]]|0.41|
|[[:human genes:f:ftsj2|FTSJ2]]|0.41|
|[[:human genes:m:mrps2|MRPS2]]|0.409|
|[[:human genes:m:mrpl45|MRPL45]]|0.409|
|[[:human genes:t:trmt10a|TRMT10A]]|0.409|
|[[:human genes:l:lsm10|LSM10]]|0.409|
|[[:human genes:r:rnmt|RNMT]]|0.406|
|[[:human genes:g:gfm2|GFM2]]|0.405|
|[[:human genes:a:alg13|ALG13]]|0.405|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.403|
|[[:human genes:n:ndufv1|NDUFV1]]|0.402|
|[[:human genes:r:rtcb|RTCB]]|0.402|
|[[:human genes:c:c12orf65|C12orf65]]|0.401|
|[[:human genes:r:rpia|RPIA]]|0.401|
|[[:human genes:t:trub2|TRUB2]]|0.4|
|[[:human genes:c:coq3|COQ3]]|0.4|
|[[:human genes:t:tmed10|TMED10]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 13/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|1/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 648
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.1 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP5A1 Expression in NALM6 Cells: 9.1'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>