======= ATP5B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP5F1B
  * **<color #00a2e8>Official Name</color>**: ATP synthase F1 subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=506|506]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P06576|P06576]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP5B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP5B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/102910|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATP-synt ab|
|ATP-synt ab C|
|ATP-synt ab N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proton-transporting ATP synthase complex, catalytic core F(1)|
|mitochondrial proton-transporting ATP synthase, catalytic core|
|proton-transporting ATP synthase complex|
|angiostatin binding|
|negative regulation of cell adhesion involved in substrate-bound cell migration|
|mitochondrial proton-transporting ATP synthase complex|
|proton-transporting ATP synthase activity, rotational mechanism|
|MHC class I protein binding|
|mitochondrial ATP synthesis coupled proton transport|
|proton-transporting ATPase activity, rotational mechanism|
|ATP synthesis coupled proton transport|
|energy coupled proton transport, down electrochemical gradient|
|substrate-dependent cell migration|
|response to interleukin-7|
|cellular response to interleukin-7|
|cristae formation|
|ATP biosynthetic process|
|mitochondrial nucleoid|
|inner mitochondrial membrane organization|
|purine ribonucleoside triphosphate biosynthetic process|
|purine nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate biosynthetic process|
|positive regulation of blood vessel endothelial cell migration|
|purine ribonucleoside triphosphate metabolic process|
|transmembrane transporter activity|
|nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|regulation of intracellular pH|
|regulation of blood vessel endothelial cell migration|
|regulation of cellular pH|
|nucleoside triphosphate metabolic process|
|mitochondrial transmembrane transport|
|regulation of pH|
|positive regulation of endothelial cell migration|
|mitochondrial membrane|
|cellular monovalent inorganic cation homeostasis|
|oxidative phosphorylation|
|osteoblast differentiation|
|mitochondrial membrane organization|
|monovalent inorganic cation homeostasis|
|positive regulation of epithelial cell migration|
|proton transmembrane transport|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|regulation of endothelial cell migration|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|ATP metabolic process|
|mitochondrial transport|
|regulation of epithelial cell migration|
|ATPase activity|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|ossification|
|negative regulation of cell adhesion|
|purine ribonucleotide metabolic process|
|angiogenesis|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|mitochondrial matrix|
|monovalent inorganic cation transport|
|blood vessel morphogenesis|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|blood vessel development|
|drug metabolic process|
|positive regulation of cell migration|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|organophosphate biosynthetic process|
|positive regulation of cellular component movement|
|nucleobase-containing small molecule metabolic process|
|positive regulation of locomotion|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|cell surface|
|carbohydrate derivative biosynthetic process|
|cellular cation homeostasis|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|tube morphogenesis|
|regulation of cell adhesion|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|tube development|
|regulation of cell migration|
|membrane organization|
|circulatory system development|
|organophosphate metabolic process|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|regulation of cell motility|
|ion transmembrane transport|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|carbohydrate derivative metabolic process|
|localization of cell|
|cell motility|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|chemical homeostasis|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|lipid metabolic process|
|mitochondrion|
|transmembrane transport|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|locomotion|
|ion transport|
|organonitrogen compound biosynthetic process|
|ATP binding|
|intracellular transport|
|movement of cell or subcellular component|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|establishment of localization in cell|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.46|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-2.02|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-1.86|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.77|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.72|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.7|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.72|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.72|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.73|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.82|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.84|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.86|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.88|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.89|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.96|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|1.97|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|2|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.01|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.02|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.02|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.02|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.03|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.06|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.07|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.07|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.09|
|[[:results:exp539|42°C R08 exp539]]|2.13|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.15|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.17|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.19|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.2|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.21|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.23|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|2.25|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.26|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.28|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.31|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.38|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.39|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|2.4|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.4|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.51|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.57|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.58|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.69|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|2.7|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.77|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.77|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.79|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.84|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.88|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.96|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|3.08|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|3.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp5o|ATP5O]]|0.844|
|[[:human genes:a:atp5a1|ATP5A1]]|0.782|
|[[:human genes:a:atp5d|ATP5D]]|0.767|
|[[:human genes:a:atp5c1|ATP5C1]]|0.693|
|[[:human genes:a:atp5f1|ATP5F1]]|0.633|
|[[:human genes:a:atp5j|ATP5J]]|0.628|
|[[:human genes:a:atp5l|ATP5L]]|0.614|
|[[:human genes:a:atp5e|ATP5E]]|0.602|
|[[:human genes:a:atp5h|ATP5H]]|0.599|
|[[:human genes:a:atp5i|ATP5I]]|0.586|
|[[:human genes:t:triap1|TRIAP1]]|0.584|
|[[:human genes:t:tmem242|TMEM242]]|0.568|
|[[:human genes:t:thg1l|THG1L]]|0.561|
|[[:human genes:b:bcs1l|BCS1L]]|0.56|
|[[:human genes:s:slc25a26|SLC25A26]]|0.554|
|[[:human genes:d:dpagt1|DPAGT1]]|0.552|
|[[:human genes:c:cox16|COX16]]|0.551|
|[[:human genes:m:mrpl21|MRPL21]]|0.549|
|[[:human genes:h:hspd1|HSPD1]]|0.548|
|[[:human genes:f:fh|FH]]|0.545|
|[[:human genes:d:dohh|DOHH]]|0.543|
|[[:human genes:p:pmm2|PMM2]]|0.531|
|[[:human genes:h:hccs|HCCS]]|0.53|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.53|
|[[:human genes:g:gfpt1|GFPT1]]|0.53|
|[[:human genes:a:atp5j2|ATP5J2]]|0.53|
|[[:human genes:d:dars2|DARS2]]|0.529|
|[[:human genes:u:ube2g2|UBE2G2]]|0.527|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.523|
|[[:human genes:p:ppa2|PPA2]]|0.52|
|[[:human genes:e:elac2|ELAC2]]|0.518|
|[[:human genes:z:zrsr2|ZRSR2]]|0.507|
|[[:human genes:d:dap3|DAP3]]|0.504|
|[[:human genes:t:trnt1|TRNT1]]|0.504|
|[[:human genes:u:uap1|UAP1]]|0.503|
|[[:human genes:m:mrps14|MRPS14]]|0.503|
|[[:human genes:d:dolk|DOLK]]|0.499|
|[[:human genes:y:yars2|YARS2]]|0.499|
|[[:human genes:w:wbscr16|WBSCR16]]|0.495|
|[[:human genes:a:atxn10|ATXN10]]|0.494|
|[[:human genes:m:med16|MED16]]|0.494|
|[[:human genes:a:adsl|ADSL]]|0.493|
|[[:human genes:s:selrc1|SELRC1]]|0.493|
|[[:human genes:m:mrps16|MRPS16]]|0.492|
|[[:human genes:g:gmppb|GMPPB]]|0.491|
|[[:human genes:a:alg1|ALG1]]|0.489|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.488|
|[[:human genes:c:cox7b|COX7B]]|0.488|
|[[:human genes:m:mrps26|MRPS26]]|0.488|
|[[:human genes:r:rars2|RARS2]]|0.487|
|[[:human genes:a:alg6|ALG6]]|0.486|
|[[:human genes:m:mbtps2|MBTPS2]]|0.485|
|[[:human genes:r:rnmt|RNMT]]|0.482|
|[[:human genes:a:alg13|ALG13]]|0.479|
|[[:human genes:m:mrps6|MRPS6]]|0.478|
|[[:human genes:h:hars2|HARS2]]|0.478|
|[[:human genes:v:vezt|VEZT]]|0.478|
|[[:human genes:p:pars2|PARS2]]|0.477|
|[[:human genes:p:pdss1|PDSS1]]|0.477|
|[[:human genes:m:mrpl20|MRPL20]]|0.475|
|[[:human genes:r:rpp21|RPP21]]|0.474|
|[[:human genes:s:ssb|SSB]]|0.474|
|[[:human genes:e:eny2|ENY2]]|0.471|
|[[:human genes:p:pnpt1|PNPT1]]|0.47|
|[[:human genes:r:rtcb|RTCB]]|0.47|
|[[:human genes:m:mrps21|MRPS21]]|0.47|
|[[:human genes:o:opa1|OPA1]]|0.47|
|[[:human genes:u:uba5|UBA5]]|0.469|
|[[:human genes:c:casp9|CASP9]]|0.469|
|[[:human genes:t:tufm|TUFM]]|0.469|
|[[:human genes:d:dhps|DHPS]]|0.468|
|[[:human genes:c:cycs|CYCS]]|0.468|
|[[:human genes:m:mrp63|MRP63]]|0.467|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.466|
|[[:human genes:r:romo1|ROMO1]]|0.465|
|[[:human genes:r:rptor|RPTOR]]|0.463|
|[[:human genes:c:c10orf2|C10orf2]]|0.462|
|[[:human genes:g:gfm1|GFM1]]|0.462|
|[[:human genes:t:tmem41b|TMEM41B]]|0.46|
|[[:human genes:r:rpusd4|RPUSD4]]|0.459|
|[[:human genes:t:tefm|TEFM]]|0.459|
|[[:human genes:t:tamm41|TAMM41]]|0.458|
|[[:human genes:p:ppp6c|PPP6C]]|0.457|
|[[:human genes:g:gatc|GATC]]|0.456|
|[[:human genes:s:sco2|SCO2]]|0.456|
|[[:human genes:l:lsm10|LSM10]]|0.455|
|[[:human genes:a:alg5|ALG5]]|0.455|
|[[:human genes:m:mrpl47|MRPL47]]|0.455|
|[[:human genes:t:taz|TAZ]]|0.452|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.452|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.452|
|[[:human genes:s:sars2|SARS2]]|0.449|
|[[:human genes:c:cbfb|CBFB]]|0.449|
|[[:human genes:f:fastkd5|FASTKD5]]|0.449|
|[[:human genes:b:bap1|BAP1]]|0.444|
|[[:human genes:m:mrpl23|MRPL23]]|0.444|
|[[:human genes:v:vars2|VARS2]]|0.443|
|[[:human genes:t:trmt5|TRMT5]]|0.443|
|[[:human genes:l:lars2|LARS2]]|0.442|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.442|
|[[:human genes:z:zbtb11|ZBTB11]]|0.441|
|[[:human genes:m:mrps34|MRPS34]]|0.44|
|[[:human genes:k:kdsr|KDSR]]|0.44|
|[[:human genes:c:c17orf89|C17orf89]]|0.44|
|[[:human genes:t:tars2|TARS2]]|0.439|
|[[:human genes:c:c1orf27|C1orf27]]|0.436|
|[[:human genes:n:ndufc2|NDUFC2]]|0.434|
|[[:human genes:m:mrps18a|MRPS18A]]|0.433|
|[[:human genes:m:mars2|MARS2]]|0.432|
|[[:human genes:n:ndufb3|NDUFB3]]|0.431|
|[[:human genes:m:mrps11|MRPS11]]|0.43|
|[[:human genes:m:mrps33|MRPS33]]|0.429|
|[[:human genes:n:nars2|NARS2]]|0.428|
|[[:human genes:p:plaa|PLAA]]|0.427|
|[[:human genes:w:wdr59|WDR59]]|0.427|
|[[:human genes:d:dhrsx|DHRSX]]|0.427|
|[[:human genes:u:urm1|URM1]]|0.426|
|[[:human genes:n:nae1|NAE1]]|0.424|
|[[:human genes:c:crls1|CRLS1]]|0.423|
|[[:human genes:h:hist1h2bk|HIST1H2BK]]|0.423|
|[[:human genes:m:mrps9|MRPS9]]|0.423|
|[[:human genes:d:dr1|DR1]]|0.422|
|[[:human genes:m:mrps5|MRPS5]]|0.422|
|[[:human genes:a:aars|AARS]]|0.42|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.419|
|[[:human genes:d:dnlz|DNLZ]]|0.418|
|[[:human genes:s:sdha|SDHA]]|0.417|
|[[:human genes:c:chchd4|CHCHD4]]|0.417|
|[[:human genes:d:dnajc3|DNAJC3]]|0.417|
|[[:human genes:u:uhrf1|UHRF1]]|0.416|
|[[:human genes:n:ndufb5|NDUFB5]]|0.415|
|[[:human genes:a:alg2|ALG2]]|0.415|
|[[:human genes:e:ears2|EARS2]]|0.415|
|[[:human genes:c:cox15|COX15]]|0.414|
|[[:human genes:e:egln1|EGLN1]]|0.414|
|[[:human genes:f:faf2|FAF2]]|0.412|
|[[:human genes:m:mrps2|MRPS2]]|0.412|
|[[:human genes:s:slc25a19|SLC25A19]]|0.412|
|[[:human genes:g:gfm2|GFM2]]|0.411|
|[[:human genes:t:trmt10a|TRMT10A]]|0.411|
|[[:human genes:p:ppcs|PPCS]]|0.41|
|[[:human genes:d:ddx1|DDX1]]|0.41|
|[[:human genes:b:bak1|BAK1]]|0.409|
|[[:human genes:g:gnb1l|GNB1L]]|0.408|
|[[:human genes:s:serf2|SERF2]]|0.407|
|[[:human genes:s:slc35b1|SLC35B1]]|0.407|
|[[:human genes:a:apaf1|APAF1]]|0.407|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.407|
|[[:human genes:t:timm13|TIMM13]]|0.407|
|[[:human genes:e:exoc4|EXOC4]]|0.405|
|[[:human genes:r:rft1|RFT1]]|0.405|
|[[:human genes:t:txnl4b|TXNL4B]]|0.405|
|[[:human genes:u:uqcr10|UQCR10]]|0.405|
|[[:human genes:m:mrps25|MRPS25]]|0.404|
|[[:human genes:m:mrps23|MRPS23]]|0.404|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.404|
|[[:human genes:n:ndufa3|NDUFA3]]|0.403|
|[[:human genes:s:slc25a52|SLC25A52]]|0.403|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.402|
|[[:human genes:s:sec62|SEC62]]|0.402|
|[[:human genes:c:cox5a|COX5A]]|0.402|
|[[:human genes:p:pggt1b|PGGT1B]]|0.401|
|[[:human genes:t:tti1|TTI1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 227/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|8/28|
|blood|8/28|
|bone|8/26|
|breast|14/33|
|central nervous system|14/56|
|cervix|3/4|
|colorectal|7/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|7/21|
|liver|9/20|
|lung|27/75|
|lymphocyte|1/16|
|ovary|3/26|
|pancreas|6/24|
|peripheral nervous system|2/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|8/24|
|soft tissue|5/9|
|thyroid|0/2|
|upper aerodigestive|6/22|
|urinary tract|7/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 865
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP5B Expression in NALM6 Cells: 9.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>