======= ATP5D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP5F1D
  * **<color #00a2e8>Official Name</color>**: ATP synthase F1 subunit delta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=513|513]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30049|P30049]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP5D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP5D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603150|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATP-synt DE N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)|
|mitochondrial proton-transporting ATP synthase complex assembly|
|proton-transporting ATP synthase complex assembly|
|proton-transporting two-sector ATPase complex assembly|
|mitochondrial proton-transporting ATP synthase complex|
|proton-transporting ATP synthase activity, rotational mechanism|
|mitochondrial ATP synthesis coupled proton transport|
|energy coupled proton transport, down electrochemical gradient|
|ATP synthesis coupled proton transport|
|cristae formation|
|ATP biosynthetic process|
|ADP binding|
|inner mitochondrial membrane organization|
|response to copper ion|
|purine ribonucleoside triphosphate biosynthetic process|
|purine nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate biosynthetic process|
|purine ribonucleoside triphosphate metabolic process|
|transmembrane transporter activity|
|nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|aerobic respiration|
|mitochondrial transmembrane transport|
|nucleoside triphosphate metabolic process|
|oxidative phosphorylation|
|mitochondrial membrane organization|
|proton transmembrane transport|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|cellular respiration|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|ATP metabolic process|
|mitochondrial transport|
|energy derivation by oxidation of organic compounds|
|ATPase activity|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|mitochondrial matrix|
|response to metal ion|
|mitochondrial inner membrane|
|monovalent inorganic cation transport|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|drug metabolic process|
|response to inorganic substance|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|carbohydrate derivative biosynthetic process|
|inorganic ion transmembrane transport|
|cation transport|
|cellular protein-containing complex assembly|
|membrane organization|
|organophosphate metabolic process|
|ion transmembrane transport|
|oxidation-reduction process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|transmembrane transport|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|ion transport|
|organonitrogen compound biosynthetic process|
|ATP binding|
|intracellular transport|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|establishment of localization in cell|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.94|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.71|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.72|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.73|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.73|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.74|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.76|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.76|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.76|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.78|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.79|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.8|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|1.81|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.84|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.88|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.91|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|1.92|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.01|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.02|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.03|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|2.06|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.09|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.1|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.15|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.17|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.26|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.29|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.32|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.32|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.33|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.36|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.42|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.48|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.59|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|2.83|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|3.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp5a1|ATP5A1]]|0.776|
|[[:human genes:a:atp5b|ATP5B]]|0.767|
|[[:human genes:a:atp5o|ATP5O]]|0.73|
|[[:human genes:a:atp5c1|ATP5C1]]|0.69|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.609|
|[[:human genes:b:bcs1l|BCS1L]]|0.587|
|[[:human genes:a:atp5h|ATP5H]]|0.586|
|[[:human genes:m:mrpl21|MRPL21]]|0.585|
|[[:human genes:a:atp5l|ATP5L]]|0.583|
|[[:human genes:g:gatc|GATC]]|0.581|
|[[:human genes:a:atp5e|ATP5E]]|0.576|
|[[:human genes:t:tmem242|TMEM242]]|0.572|
|[[:human genes:a:atp5i|ATP5I]]|0.572|
|[[:human genes:d:dars2|DARS2]]|0.56|
|[[:human genes:a:atp5f1|ATP5F1]]|0.559|
|[[:human genes:a:atp5j|ATP5J]]|0.555|
|[[:human genes:c:cox16|COX16]]|0.543|
|[[:human genes:s:selrc1|SELRC1]]|0.541|
|[[:human genes:p:pars2|PARS2]]|0.539|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.538|
|[[:human genes:y:yars2|YARS2]]|0.538|
|[[:human genes:a:atp5j2|ATP5J2]]|0.537|
|[[:human genes:d:dohh|DOHH]]|0.536|
|[[:human genes:d:dap3|DAP3]]|0.533|
|[[:human genes:o:opa1|OPA1]]|0.531|
|[[:human genes:w:wbscr16|WBSCR16]]|0.529|
|[[:human genes:s:slc25a26|SLC25A26]]|0.525|
|[[:human genes:m:mrpl23|MRPL23]]|0.525|
|[[:human genes:p:pdss1|PDSS1]]|0.521|
|[[:human genes:t:triap1|TRIAP1]]|0.515|
|[[:human genes:p:pnpt1|PNPT1]]|0.515|
|[[:human genes:m:mrps21|MRPS21]]|0.514|
|[[:human genes:m:mrps14|MRPS14]]|0.513|
|[[:human genes:p:pmm2|PMM2]]|0.511|
|[[:human genes:f:fastkd5|FASTKD5]]|0.51|
|[[:human genes:c:c17orf89|C17orf89]]|0.508|
|[[:human genes:m:mrps34|MRPS34]]|0.508|
|[[:human genes:f:fh|FH]]|0.508|
|[[:human genes:m:mrps5|MRPS5]]|0.503|
|[[:human genes:p:ppa2|PPA2]]|0.501|
|[[:human genes:t:tars2|TARS2]]|0.5|
|[[:human genes:s:sco2|SCO2]]|0.498|
|[[:human genes:r:rpusd4|RPUSD4]]|0.498|
|[[:human genes:m:mrps26|MRPS26]]|0.498|
|[[:human genes:s:slc25a3|SLC25A3]]|0.497|
|[[:human genes:m:mrp63|MRP63]]|0.497|
|[[:human genes:q:qrsl1|QRSL1]]|0.496|
|[[:human genes:m:mrps6|MRPS6]]|0.492|
|[[:human genes:g:gfm1|GFM1]]|0.491|
|[[:human genes:n:ndufa3|NDUFA3]]|0.491|
|[[:human genes:t:thg1l|THG1L]]|0.49|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.49|
|[[:human genes:g:gfm2|GFM2]]|0.489|
|[[:human genes:m:mrpl47|MRPL47]]|0.488|
|[[:human genes:v:vars2|VARS2]]|0.488|
|[[:human genes:c:cox7b|COX7B]]|0.488|
|[[:human genes:t:tefm|TEFM]]|0.486|
|[[:human genes:e:ears2|EARS2]]|0.484|
|[[:human genes:m:mbtps2|MBTPS2]]|0.483|
|[[:human genes:n:ndufa1|NDUFA1]]|0.482|
|[[:human genes:s:sars2|SARS2]]|0.482|
|[[:human genes:t:tufm|TUFM]]|0.482|
|[[:human genes:m:mrps18a|MRPS18A]]|0.479|
|[[:human genes:n:ndufc2|NDUFC2]]|0.479|
|[[:human genes:m:mrpl53|MRPL53]]|0.476|
|[[:human genes:u:ube2g2|UBE2G2]]|0.476|
|[[:human genes:n:ndufb5|NDUFB5]]|0.474|
|[[:human genes:m:mrps16|MRPS16]]|0.471|
|[[:human genes:r:rars2|RARS2]]|0.467|
|[[:human genes:h:hars2|HARS2]]|0.466|
|[[:human genes:c:c10orf2|C10orf2]]|0.464|
|[[:human genes:t:taz|TAZ]]|0.461|
|[[:human genes:t:trub2|TRUB2]]|0.46|
|[[:human genes:n:ndufb11|NDUFB11]]|0.459|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.459|
|[[:human genes:m:mrpl20|MRPL20]]|0.458|
|[[:human genes:a:alg6|ALG6]]|0.458|
|[[:human genes:c:cycs|CYCS]]|0.456|
|[[:human genes:g:gfpt1|GFPT1]]|0.456|
|[[:human genes:u:uap1|UAP1]]|0.456|
|[[:human genes:n:ndufb3|NDUFB3]]|0.456|
|[[:human genes:h:hccs|HCCS]]|0.454|
|[[:human genes:e:elac2|ELAC2]]|0.454|
|[[:human genes:l:lars2|LARS2]]|0.453|
|[[:human genes:m:mrps23|MRPS23]]|0.453|
|[[:human genes:r:romo1|ROMO1]]|0.453|
|[[:human genes:d:dpagt1|DPAGT1]]|0.452|
|[[:human genes:d:dnlz|DNLZ]]|0.452|
|[[:human genes:r:rpia|RPIA]]|0.451|
|[[:human genes:n:nars2|NARS2]]|0.451|
|[[:human genes:m:mrps11|MRPS11]]|0.451|
|[[:human genes:m:mrpl34|MRPL34]]|0.45|
|[[:human genes:t:trnt1|TRNT1]]|0.449|
|[[:human genes:s:sdha|SDHA]]|0.449|
|[[:human genes:n:ndufa2|NDUFA2]]|0.447|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.445|
|[[:human genes:a:alg1|ALG1]]|0.444|
|[[:human genes:u:uqcrq|UQCRQ]]|0.44|
|[[:human genes:m:mrpl15|MRPL15]]|0.438|
|[[:human genes:m:mrps2|MRPS2]]|0.437|
|[[:human genes:m:mtg1|MTG1]]|0.435|
|[[:human genes:f:ftsj2|FTSJ2]]|0.435|
|[[:human genes:m:mrps25|MRPS25]]|0.433|
|[[:human genes:a:atxn10|ATXN10]]|0.433|
|[[:human genes:l:lsm10|LSM10]]|0.432|
|[[:human genes:d:dhrsx|DHRSX]]|0.431|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.431|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.43|
|[[:human genes:m:minos1|MINOS1]]|0.43|
|[[:human genes:m:mrps33|MRPS33]]|0.43|
|[[:human genes:c:cbfb|CBFB]]|0.43|
|[[:human genes:c:chchd4|CHCHD4]]|0.429|
|[[:human genes:c:cox17|COX17]]|0.426|
|[[:human genes:r:rbfa|RBFA]]|0.426|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.425|
|[[:human genes:s:sec62|SEC62]]|0.424|
|[[:human genes:k:kdsr|KDSR]]|0.423|
|[[:human genes:n:ndufv1|NDUFV1]]|0.422|
|[[:human genes:r:rpusd3|RPUSD3]]|0.422|
|[[:human genes:m:mars2|MARS2]]|0.422|
|[[:human genes:t:trmt10a|TRMT10A]]|0.421|
|[[:human genes:n:ndufb1|NDUFB1]]|0.421|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.42|
|[[:human genes:m:mrpl45|MRPL45]]|0.42|
|[[:human genes:v:vezt|VEZT]]|0.419|
|[[:human genes:m:mrps9|MRPS9]]|0.419|
|[[:human genes:m:mrpl55|MRPL55]]|0.418|
|[[:human genes:h:hspd1|HSPD1]]|0.417|
|[[:human genes:m:mtif3|MTIF3]]|0.417|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.414|
|[[:human genes:p:pgs1|PGS1]]|0.414|
|[[:human genes:m:med16|MED16]]|0.414|
|[[:human genes:d:dnajc3|DNAJC3]]|0.414|
|[[:human genes:m:mtpap|MTPAP]]|0.413|
|[[:human genes:r:rptor|RPTOR]]|0.413|
|[[:human genes:c:crls1|CRLS1]]|0.412|
|[[:human genes:r:rnmt|RNMT]]|0.411|
|[[:human genes:m:mrpl12|MRPL12]]|0.411|
|[[:human genes:s:serf2|SERF2]]|0.411|
|[[:human genes:c:casp9|CASP9]]|0.41|
|[[:human genes:s:slc25a52|SLC25A52]]|0.409|
|[[:human genes:r:rpp21|RPP21]]|0.408|
|[[:human genes:c:cox15|COX15]]|0.408|
|[[:human genes:t:tmem41b|TMEM41B]]|0.404|
|[[:human genes:n:ndufs7|NDUFS7]]|0.404|
|[[:human genes:t:trmt61a|TRMT61A]]|0.401|
|[[:human genes:t:tmem126b|TMEM126B]]|0.401|
|[[:human genes:a:alg5|ALG5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 208/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|9/28|
|blood|3/28|
|bone|5/26|
|breast|11/33|
|central nervous system|12/56|
|cervix|3/4|
|colorectal|6/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|7/16|
|kidney|6/21|
|liver|12/20|
|lung|26/75|
|lymphocyte|5/16|
|ovary|10/26|
|pancreas|4/24|
|peripheral nervous system|4/16|
|plasma cell|4/15|
|prostate|1/1|
|skin|4/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|8/22|
|urinary tract|8/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 457
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP5D Expression in NALM6 Cells: 5.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>