======= ATP5F1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP5PB
  * **<color #00a2e8>Official Name</color>**: ATP synthase peripheral stalk-membrane subunit b
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=515|515]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P24539|P24539]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP5F1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP5F1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603270|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mt ATP-synt B|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|
|proton-transporting ATP synthase activity, rotational mechanism|
|mitochondrial proton-transporting ATP synthase complex|
|mitochondrial ATP synthesis coupled proton transport|
|ATP synthesis coupled proton transport|
|energy coupled proton transport, down electrochemical gradient|
|cristae formation|
|ATP biosynthetic process|
|substantia nigra development|
|inner mitochondrial membrane organization|
|purine ribonucleoside triphosphate biosynthetic process|
|purine nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate biosynthetic process|
|purine ribonucleoside triphosphate metabolic process|
|transmembrane transporter activity|
|neural nucleus development|
|nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|midbrain development|
|nucleoside triphosphate metabolic process|
|mitochondrial transmembrane transport|
|oxidative phosphorylation|
|mitochondrial membrane organization|
|proton transmembrane transport|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|ATP metabolic process|
|mitochondrial transport|
|ATPase activity|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|mitochondrial matrix|
|mitochondrial inner membrane|
|monovalent inorganic cation transport|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|drug metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|carbohydrate derivative biosynthetic process|
|inorganic ion transmembrane transport|
|brain development|
|head development|
|cation transport|
|membrane organization|
|organophosphate metabolic process|
|ion transmembrane transport|
|central nervous system development|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|transmembrane transport|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|ion transport|
|organonitrogen compound biosynthetic process|
|intracellular transport|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|establishment of localization in cell|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-1.92|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.8|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.85|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.86|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.92|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.93|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.97|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.98|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.03|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.03|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.1|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.11|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.11|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.14|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.18|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.22|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.28|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.35|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|2.37|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.52|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp5b|ATP5B]]|0.633|
|[[:human genes:a:atp5o|ATP5O]]|0.596|
|[[:human genes:a:atp5a1|ATP5A1]]|0.581|
|[[:human genes:a:atp5c1|ATP5C1]]|0.561|
|[[:human genes:a:atp5d|ATP5D]]|0.559|
|[[:human genes:a:atp5l|ATP5L]]|0.543|
|[[:human genes:a:atp5i|ATP5I]]|0.516|
|[[:human genes:a:atp5j|ATP5J]]|0.499|
|[[:human genes:t:triap1|TRIAP1]]|0.493|
|[[:human genes:b:bcs1l|BCS1L]]|0.478|
|[[:human genes:a:atp5e|ATP5E]]|0.476|
|[[:human genes:a:atp5h|ATP5H]]|0.465|
|[[:human genes:m:mrpl21|MRPL21]]|0.458|
|[[:human genes:h:hspd1|HSPD1]]|0.457|
|[[:human genes:d:dap3|DAP3]]|0.452|
|[[:human genes:c:cycs|CYCS]]|0.45|
|[[:human genes:s:slc25a26|SLC25A26]]|0.449|
|[[:human genes:p:ppa2|PPA2]]|0.444|
|[[:human genes:c:cox16|COX16]]|0.442|
|[[:human genes:e:eny2|ENY2]]|0.434|
|[[:human genes:d:dars2|DARS2]]|0.43|
|[[:human genes:h:hccs|HCCS]]|0.425|
|[[:human genes:a:atp5j2|ATP5J2]]|0.425|
|[[:human genes:h:hars2|HARS2]]|0.425|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.421|
|[[:human genes:m:mrps14|MRPS14]]|0.42|
|[[:human genes:t:thg1l|THG1L]]|0.42|
|[[:human genes:a:adsl|ADSL]]|0.417|
|[[:human genes:m:mrpl15|MRPL15]]|0.417|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.416|
|[[:human genes:a:apaf1|APAF1]]|0.413|
|[[:human genes:v:vezt|VEZT]]|0.41|
|[[:human genes:c:casp9|CASP9]]|0.406|
|[[:human genes:w:wbscr16|WBSCR16]]|0.402|
|[[:human genes:n:ndufb3|NDUFB3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 11/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2152
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP5F1 Expression in NALM6 Cells: 7.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>