======= ATP5H =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP5PD
  * **<color #00a2e8>Official Name</color>**: ATP synthase peripheral stalk subunit d
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10476|10476]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75947|O75947]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP5H&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP5H|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618121|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mt ATP-synt D|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial proton-transporting ATP synthase, stator stalk|
|mitochondrial proton-transporting ATP synthase complex|
|proton-transporting ATP synthase activity, rotational mechanism|
|mitochondrial ATP synthesis coupled proton transport|
|energy coupled proton transport, down electrochemical gradient|
|ATP synthesis coupled proton transport|
|cristae formation|
|ATP biosynthetic process|
|inner mitochondrial membrane organization|
|purine ribonucleoside triphosphate biosynthetic process|
|purine nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate biosynthetic process|
|purine ribonucleoside triphosphate metabolic process|
|transmembrane transporter activity|
|nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|mitochondrial transmembrane transport|
|nucleoside triphosphate metabolic process|
|oxidative phosphorylation|
|mitochondrial membrane organization|
|proton transmembrane transport|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|ATP metabolic process|
|mitochondrial transport|
|ATPase activity|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|mitochondrial inner membrane|
|monovalent inorganic cation transport|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|drug metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|carbohydrate derivative biosynthetic process|
|inorganic ion transmembrane transport|
|cation transport|
|membrane organization|
|organophosphate metabolic process|
|ion transmembrane transport|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|transmembrane transport|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|ion transport|
|organonitrogen compound biosynthetic process|
|intracellular transport|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp148|SB202190 10μM R03 exp148]]|-2.07|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.72|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.75|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|1.75|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.82|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.92|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.94|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.94|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.01|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.02|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.06|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp5o|ATP5O]]|0.613|
|[[:human genes:a:atp5b|ATP5B]]|0.599|
|[[:human genes:a:atp5d|ATP5D]]|0.586|
|[[:human genes:a:atp5a1|ATP5A1]]|0.582|
|[[:human genes:t:triap1|TRIAP1]]|0.537|
|[[:human genes:a:atp5c1|ATP5C1]]|0.527|
|[[:human genes:p:pmm2|PMM2]]|0.502|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.494|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.491|
|[[:human genes:w:wbscr16|WBSCR16]]|0.49|
|[[:human genes:s:slc25a26|SLC25A26]]|0.486|
|[[:human genes:a:atp5e|ATP5E]]|0.481|
|[[:human genes:a:atp5l|ATP5L]]|0.479|
|[[:human genes:t:tmem242|TMEM242]]|0.477|
|[[:human genes:c:c17orf89|C17orf89]]|0.47|
|[[:human genes:f:fh|FH]]|0.469|
|[[:human genes:m:mrps16|MRPS16]]|0.468|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.468|
|[[:human genes:d:dap3|DAP3]]|0.466|
|[[:human genes:a:atp5f1|ATP5F1]]|0.465|
|[[:human genes:t:thg1l|THG1L]]|0.461|
|[[:human genes:b:bcs1l|BCS1L]]|0.459|
|[[:human genes:d:dars2|DARS2]]|0.455|
|[[:human genes:d:dpagt1|DPAGT1]]|0.453|
|[[:human genes:a:atp5j|ATP5J]]|0.453|
|[[:human genes:c:cox16|COX16]]|0.453|
|[[:human genes:g:gatc|GATC]]|0.451|
|[[:human genes:g:gfm1|GFM1]]|0.451|
|[[:human genes:y:yars2|YARS2]]|0.45|
|[[:human genes:m:mrps21|MRPS21]]|0.449|
|[[:human genes:r:rars2|RARS2]]|0.445|
|[[:human genes:n:ndufb1|NDUFB1]]|0.445|
|[[:human genes:m:mrps33|MRPS33]]|0.441|
|[[:human genes:m:mrps14|MRPS14]]|0.439|
|[[:human genes:p:pars2|PARS2]]|0.439|
|[[:human genes:u:ube2g2|UBE2G2]]|0.436|
|[[:human genes:a:alg6|ALG6]]|0.436|
|[[:human genes:g:gfpt1|GFPT1]]|0.431|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.43|
|[[:human genes:h:hars2|HARS2]]|0.43|
|[[:human genes:c:c10orf2|C10orf2]]|0.429|
|[[:human genes:m:mrpl21|MRPL21]]|0.429|
|[[:human genes:u:uhrf1|UHRF1]]|0.428|
|[[:human genes:m:mrps6|MRPS6]]|0.427|
|[[:human genes:v:vezt|VEZT]]|0.426|
|[[:human genes:b:bap1|BAP1]]|0.425|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.424|
|[[:human genes:a:alg1|ALG1]]|0.423|
|[[:human genes:m:mrp63|MRP63]]|0.422|
|[[:human genes:s:selrc1|SELRC1]]|0.422|
|[[:human genes:t:tars2|TARS2]]|0.422|
|[[:human genes:t:tefm|TEFM]]|0.421|
|[[:human genes:m:mrps34|MRPS34]]|0.421|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.42|
|[[:human genes:m:mrpl23|MRPL23]]|0.419|
|[[:human genes:n:ndufb5|NDUFB5]]|0.419|
|[[:human genes:r:rnmt|RNMT]]|0.419|
|[[:human genes:g:gfm2|GFM2]]|0.419|
|[[:human genes:t:txnrd1|TXNRD1]]|0.419|
|[[:human genes:d:dohh|DOHH]]|0.417|
|[[:human genes:m:mrpl47|MRPL47]]|0.417|
|[[:human genes:a:atxn10|ATXN10]]|0.416|
|[[:human genes:r:rptor|RPTOR]]|0.415|
|[[:human genes:u:ube2m|UBE2M]]|0.415|
|[[:human genes:a:adsl|ADSL]]|0.41|
|[[:human genes:n:ndufc2|NDUFC2]]|0.409|
|[[:human genes:s:ssb|SSB]]|0.409|
|[[:human genes:r:romo1|ROMO1]]|0.408|
|[[:human genes:p:pelo|PELO]]|0.407|
|[[:human genes:p:ppa2|PPA2]]|0.407|
|[[:human genes:r:rpia|RPIA]]|0.406|
|[[:human genes:t:trmt10a|TRMT10A]]|0.406|
|[[:human genes:p:pdss1|PDSS1]]|0.405|
|[[:human genes:h:hccs|HCCS]]|0.405|
|[[:human genes:a:atp5i|ATP5I]]|0.404|
|[[:human genes:e:ears2|EARS2]]|0.404|
|[[:human genes:s:serf2|SERF2]]|0.403|
|[[:human genes:s:slc25a3|SLC25A3]]|0.403|
|[[:human genes:s:sco2|SCO2]]|0.403|
|[[:human genes:c:cbfb|CBFB]]|0.402|
|[[:human genes:d:dhrsx|DHRSX]]|0.402|
|[[:human genes:d:dolk|DOLK]]|0.401|
|[[:human genes:n:ndufa3|NDUFA3]]|0.4|
|[[:human genes:f:fastkd5|FASTKD5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2586
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP5H Expression in NALM6 Cells: 5.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>