======= ATP5J2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP5MF
  * **<color #00a2e8>Official Name</color>**: ATP synthase membrane subunit f
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9551|9551]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56134|P56134]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP5J2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP5J2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619792|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WRW|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|
|mitochondrial proton-transporting ATP synthase complex|
|mitochondrial ATP synthesis coupled proton transport|
|energy coupled proton transport, down electrochemical gradient|
|ATP synthesis coupled proton transport|
|cristae formation|
|ATP biosynthetic process|
|inner mitochondrial membrane organization|
|purine ribonucleoside triphosphate biosynthetic process|
|purine nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate biosynthetic process|
|purine ribonucleoside triphosphate metabolic process|
|transmembrane transporter activity|
|nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|mitochondrial transmembrane transport|
|nucleoside triphosphate metabolic process|
|oxidative phosphorylation|
|mitochondrial membrane organization|
|proton transmembrane transport|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|ATP metabolic process|
|mitochondrial transport|
|ATPase activity|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|mitochondrial inner membrane|
|monovalent inorganic cation transport|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|drug metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|carbohydrate derivative biosynthetic process|
|inorganic ion transmembrane transport|
|cation transport|
|membrane organization|
|organophosphate metabolic process|
|ion transmembrane transport|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|transmembrane transport|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|ion transport|
|organonitrogen compound biosynthetic process|
|intracellular transport|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp275|Citral 75μM R06 exp275]]|1.75|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.76|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.79|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.86|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|1.89|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.92|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp5a1|ATP5A1]]|0.549|
|[[:human genes:a:atp5o|ATP5O]]|0.542|
|[[:human genes:a:atp5d|ATP5D]]|0.537|
|[[:human genes:a:atp5b|ATP5B]]|0.53|
|[[:human genes:a:atp5c1|ATP5C1]]|0.498|
|[[:human genes:a:atp5e|ATP5E]]|0.484|
|[[:human genes:a:atp5l|ATP5L]]|0.443|
|[[:human genes:a:atp5f1|ATP5F1]]|0.425|
|[[:human genes:s:slc25a3|SLC25A3]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 74/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|3/28|
|bone|0/26|
|breast|4/33|
|central nervous system|2/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|2/21|
|liver|6/20|
|lung|5/75|
|lymphocyte|1/16|
|ovary|4/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|3/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1722
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP5J2 Expression in NALM6 Cells: 6.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>