======= ATP5SL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DMAC2
  * **<color #00a2e8>Official Name</color>**: distal membrane arm assembly complex 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55101|55101]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NW81|Q9NW81]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP5SL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP5SL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617262|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I. {ECO:0000269|PubMed:27626371}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial respiratory chain complex I|
|mitochondrial respiratory chain complex I assembly|
|SCF ubiquitin ligase complex|
|NADH dehydrogenase complex assembly|
|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|
|mitochondrial respiratory chain complex assembly|
|ubiquitin-protein transferase activity|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|mitochondrion organization|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|protein modification by small protein conjugation|
|cellular protein-containing complex assembly|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|proteolysis|
|protein-containing complex assembly|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp219|A-395N 10μM R05 exp219]]|-2.08|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-1.83|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.82|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-1.79|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.71|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.74|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.76|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.8|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.38|
|[[:results:exp534|Trientine 500μM R08 exp534]]|2.39|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.7|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufb11|NDUFB11]]|0.607|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.567|
|[[:human genes:g:grsf1|GRSF1]]|0.565|
|[[:human genes:n:ndufc2|NDUFC2]]|0.557|
|[[:human genes:m:mrps21|MRPS21]]|0.553|
|[[:human genes:n:ndufa3|NDUFA3]]|0.549|
|[[:human genes:n:ndufa1|NDUFA1]]|0.546|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.544|
|[[:human genes:n:nars2|NARS2]]|0.541|
|[[:human genes:d:dap3|DAP3]]|0.536|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.534|
|[[:human genes:t:tefm|TEFM]]|0.533|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.53|
|[[:human genes:n:ndufa11|NDUFA11]]|0.528|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.527|
|[[:human genes:l:lars2|LARS2]]|0.526|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.526|
|[[:human genes:y:yars2|YARS2]]|0.525|
|[[:human genes:q:qrsl1|QRSL1]]|0.525|
|[[:human genes:e:ecsit|ECSIT]]|0.522|
|[[:human genes:m:mrps5|MRPS5]]|0.519|
|[[:human genes:m:mrpl15|MRPL15]]|0.519|
|[[:human genes:n:ndufa2|NDUFA2]]|0.518|
|[[:human genes:m:mrpl47|MRPL47]]|0.518|
|[[:human genes:g:gfm1|GFM1]]|0.517|
|[[:human genes:m:mrps33|MRPS33]]|0.517|
|[[:human genes:m:mrpl21|MRPL21]]|0.517|
|[[:human genes:e:ears2|EARS2]]|0.514|
|[[:human genes:m:mrps6|MRPS6]]|0.514|
|[[:human genes:n:ndufb6|NDUFB6]]|0.513|
|[[:human genes:a:acad9|ACAD9]]|0.508|
|[[:human genes:t:tmem261|TMEM261]]|0.507|
|[[:human genes:g:gfm2|GFM2]]|0.506|
|[[:human genes:p:pet112|PET112]]|0.506|
|[[:human genes:f:ftsj2|FTSJ2]]|0.506|
|[[:human genes:p:pdss1|PDSS1]]|0.506|
|[[:human genes:r:rars2|RARS2]]|0.505|
|[[:human genes:n:ndufb5|NDUFB5]]|0.504|
|[[:human genes:m:mrpl45|MRPL45]]|0.503|
|[[:human genes:m:mto1|MTO1]]|0.502|
|[[:human genes:m:mrps14|MRPS14]]|0.501|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.499|
|[[:human genes:f:fastkd2|FASTKD2]]|0.499|
|[[:human genes:m:mars2|MARS2]]|0.499|
|[[:human genes:n:ndufb9|NDUFB9]]|0.498|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.498|
|[[:human genes:c:c12orf65|C12orf65]]|0.495|
|[[:human genes:d:dars2|DARS2]]|0.495|
|[[:human genes:m:mrps16|MRPS16]]|0.495|
|[[:human genes:g:gatc|GATC]]|0.491|
|[[:human genes:c:c10orf2|C10orf2]]|0.489|
|[[:human genes:r:rpusd3|RPUSD3]]|0.486|
|[[:human genes:n:ndufs2|NDUFS2]]|0.485|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.484|
|[[:human genes:c:cars2|CARS2]]|0.483|
|[[:human genes:m:mrps34|MRPS34]]|0.482|
|[[:human genes:m:mrp63|MRP63]]|0.479|
|[[:human genes:t:tars2|TARS2]]|0.479|
|[[:human genes:c:c17orf89|C17orf89]]|0.478|
|[[:human genes:w:wbscr16|WBSCR16]]|0.475|
|[[:human genes:s:selrc1|SELRC1]]|0.473|
|[[:human genes:n:ndufs7|NDUFS7]]|0.471|
|[[:human genes:n:ndufb7|NDUFB7]]|0.47|
|[[:human genes:n:ndufb3|NDUFB3]]|0.469|
|[[:human genes:r:rpusd4|RPUSD4]]|0.466|
|[[:human genes:t:tufm|TUFM]]|0.464|
|[[:human genes:m:mrpl53|MRPL53]]|0.463|
|[[:human genes:n:ndufs5|NDUFS5]]|0.463|
|[[:human genes:a:aifm1|AIFM1]]|0.461|
|[[:human genes:m:mrpl23|MRPL23]]|0.46|
|[[:human genes:m:mtg2|MTG2]]|0.459|
|[[:human genes:r:rbfa|RBFA]]|0.458|
|[[:human genes:n:ndufa10|NDUFA10]]|0.456|
|[[:human genes:n:ndufa8|NDUFA8]]|0.455|
|[[:human genes:p:pnpt1|PNPT1]]|0.454|
|[[:human genes:p:pars2|PARS2]]|0.454|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.452|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.452|
|[[:human genes:s:ssbp1|SSBP1]]|0.451|
|[[:human genes:f:foxred1|FOXRED1]]|0.451|
|[[:human genes:m:mipep|MIPEP]]|0.448|
|[[:human genes:p:polg|POLG]]|0.445|
|[[:human genes:n:ndufv1|NDUFV1]]|0.444|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.444|
|[[:human genes:m:mterfd1|MTERFD1]]|0.443|
|[[:human genes:n:ndufs3|NDUFS3]]|0.442|
|[[:human genes:m:mrps22|MRPS22]]|0.442|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.442|
|[[:human genes:m:mrpl42|MRPL42]]|0.44|
|[[:human genes:m:mcat|MCAT]]|0.44|
|[[:human genes:m:mtg1|MTG1]]|0.439|
|[[:human genes:n:nubpl|NUBPL]]|0.438|
|[[:human genes:m:mrpl12|MRPL12]]|0.438|
|[[:human genes:p:polrmt|POLRMT]]|0.437|
|[[:human genes:m:mrps26|MRPS26]]|0.436|
|[[:human genes:n:nfu1|NFU1]]|0.434|
|[[:human genes:f:fastkd5|FASTKD5]]|0.434|
|[[:human genes:c:cox16|COX16]]|0.433|
|[[:human genes:m:mettl17|METTL17]]|0.432|
|[[:human genes:t:timm21|TIMM21]]|0.432|
|[[:human genes:c:chchd1|CHCHD1]]|0.431|
|[[:human genes:m:mrps25|MRPS25]]|0.43|
|[[:human genes:m:mrpl22|MRPL22]]|0.429|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.428|
|[[:human genes:s:slc25a26|SLC25A26]]|0.425|
|[[:human genes:s:sars2|SARS2]]|0.425|
|[[:human genes:m:mrps11|MRPS11]]|0.424|
|[[:human genes:m:mtif2|MTIF2]]|0.424|
|[[:human genes:d:ddx28|DDX28]]|0.423|
|[[:human genes:t:tfb1m|TFB1M]]|0.423|
|[[:human genes:p:polg2|POLG2]]|0.423|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.422|
|[[:human genes:m:mrpl3|MRPL3]]|0.422|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.419|
|[[:human genes:a:aars2|AARS2]]|0.419|
|[[:human genes:w:wars2|WARS2]]|0.419|
|[[:human genes:i:iba57|IBA57]]|0.417|
|[[:human genes:n:ndufb2|NDUFB2]]|0.417|
|[[:human genes:h:hars2|HARS2]]|0.416|
|[[:human genes:c:cox17|COX17]]|0.415|
|[[:human genes:t:tomm20|TOMM20]]|0.415|
|[[:human genes:c:coq7|COQ7]]|0.413|
|[[:human genes:b:bcs1l|BCS1L]]|0.412|
|[[:human genes:m:mrps9|MRPS9]]|0.412|
|[[:human genes:p:pgm3|PGM3]]|0.41|
|[[:human genes:t:trmt10c|TRMT10C]]|0.409|
|[[:human genes:v:vars2|VARS2]]|0.409|
|[[:human genes:m:mrpl17|MRPL17]]|0.408|
|[[:human genes:t:tmem242|TMEM242]]|0.406|
|[[:human genes:m:mrpl4|MRPL4]]|0.404|
|[[:human genes:c:coq2|COQ2]]|0.402|
|[[:human genes:s:sco2|SCO2]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2398
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP5SL Expression in NALM6 Cells: 5.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>