======= ATP6V0B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP6V0B
  * **<color #00a2e8>Official Name</color>**: ATPase H+ transporting V0 subunit b
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=533|533]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99437|Q99437]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP6V0B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP6V0B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603717|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATP-synt C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proton-transporting V-type ATPase, V0 domain|
|proton-transporting ATPase activity, rotational mechanism|
|vacuolar membrane|
|phagosome acidification|
|transferrin transport|
|transporter activity|
|phagosome maturation|
|intracellular pH reduction|
|pH reduction|
|iron ion transport|
|phagocytic vesicle membrane|
|regulation of intracellular pH|
|insulin receptor signaling pathway|
|regulation of cellular pH|
|regulation of pH|
|cellular monovalent inorganic cation homeostasis|
|transition metal ion transport|
|monovalent inorganic cation homeostasis|
|proton transmembrane transport|
|cellular response to insulin stimulus|
|regulation of macroautophagy|
|endosome membrane|
|response to insulin|
|cellular response to peptide hormone stimulus|
|cellular response to peptide|
|regulation of autophagy|
|response to peptide hormone|
|monovalent inorganic cation transport|
|response to peptide|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|inorganic cation transmembrane transport|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|regulation of cellular catabolic process|
|cellular homeostasis|
|response to hormone|
|ion transmembrane transport|
|regulation of catabolic process|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|response to endogenous stimulus|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|establishment of protein localization|
|homeostatic process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.99|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.87|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-2.72|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-2.7|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-2.64|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-2.52|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.45|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.45|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-2.43|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-2.42|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.41|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.41|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.36|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.33|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-2.29|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.24|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.21|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-2.18|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-2.12|
|[[:results:exp518|RK-33 8μM R08 exp518]]|-2.12|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.07|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.02|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-2.01|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.92|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.91|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.89|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-1.84|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-1.82|
|[[:results:exp539|42°C R08 exp539]]|-1.81|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.76|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.75|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.72|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.7|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.75|
|[[:results:exp149|SB203580 25μM R03 exp149]]|1.8|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|2.01|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.08|
|[[:results:exp124|GSK343 3μM R03 exp124]]|2.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.648|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.531|
|[[:human genes:p:polr2j3|POLR2J3]]|0.521|
|[[:human genes:u:upf1|UPF1]]|0.5|
|[[:human genes:p:psmb2|PSMB2]]|0.493|
|[[:human genes:p:psmb4|PSMB4]]|0.484|
|[[:human genes:c:copg1|COPG1]]|0.482|
|[[:human genes:c:cope|COPE]]|0.466|
|[[:human genes:e:exosc5|EXOSC5]]|0.463|
|[[:human genes:s:supt6h|SUPT6H]]|0.461|
|[[:human genes:u:utp3|UTP3]]|0.46|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.46|
|[[:human genes:r:rbbp5|RBBP5]]|0.455|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.454|
|[[:human genes:p:pola1|POLA1]]|0.453|
|[[:human genes:w:wdr75|WDR75]]|0.452|
|[[:human genes:s:supt5h|SUPT5H]]|0.451|
|[[:human genes:r:rrp7a|RRP7A]]|0.449|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.447|
|[[:human genes:s:slc6a17|SLC6A17]]|0.443|
|[[:human genes:i:ik|IK]]|0.441|
|[[:human genes:s:slc4a1|SLC4A1]]|0.439|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.438|
|[[:human genes:x:xab2|XAB2]]|0.438|
|[[:human genes:v:vps52|VPS52]]|0.436|
|[[:human genes:t:tuba8|TUBA8]]|0.436|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.434|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.433|
|[[:human genes:r:rpl35|RPL35]]|0.433|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.433|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.432|
|[[:human genes:c:c14orf93|C14orf93]]|0.43|
|[[:human genes:t:tceb3c|TCEB3C]]|0.43|
|[[:human genes:c:copb1|COPB1]]|0.429|
|[[:human genes:p:psma6|PSMA6]]|0.429|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.427|
|[[:human genes:c:chmp4b|CHMP4B]]|0.427|
|[[:human genes:t:ticrr|TICRR]]|0.425|
|[[:human genes:c:chd4|CHD4]]|0.424|
|[[:human genes:p:psmc2|PSMC2]]|0.424|
|[[:human genes:z:znf655|ZNF655]]|0.422|
|[[:human genes:n:nbpf10|NBPF10]]|0.422|
|[[:human genes:g:gar1|GAR1]]|0.421|
|[[:human genes:r:ranbp2|RANBP2]]|0.421|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.418|
|[[:human genes:m:med17|MED17]]|0.418|
|[[:human genes:c:cdc45|CDC45]]|0.416|
|[[:human genes:r:rnf113a|RNF113A]]|0.416|
|[[:human genes:r:rps2|RPS2]]|0.413|
|[[:human genes:o:osbp|OSBP]]|0.413|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.413|
|[[:human genes:n:nup160|NUP160]]|0.412|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.409|
|[[:human genes:k:kctd17|KCTD17]]|0.408|
|[[:human genes:d:ddtl|DDTL]]|0.406|
|[[:human genes:a:atp6v0a2|ATP6V0A2]]|0.402|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.401|
|[[:human genes:c:copb2|COPB2]]|0.4|
|[[:human genes:p:pcf11|PCF11]]|0.4|
|[[:human genes:c:ctage4|CTAGE4]]|0.4|
|[[:human genes:t:twistnb|TWISTNB]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 733/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/26|
|breast|33/33|
|central nervous system|54/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|1/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 362
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP6V0B Expression in NALM6 Cells: 6.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>