======= ATP8A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP8A1
  * **<color #00a2e8>Official Name</color>**: ATPase phospholipid transporting 8A1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10396|10396]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2Q0|Q9Y2Q0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP8A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP8A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609542|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Acts as aminophospholipid translocase at the plasma membrane in neuronal cells.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|E1-E2 ATPase|
|HAD|
|Hydrolase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ATPase-coupled cation transmembrane transporter activity|
|regulation of phospholipid translocation|
|positive regulation of phospholipid translocation|
|chromaffin granule membrane|
|regulation of phospholipid transport|
|positive regulation of phospholipid transport|
|ATPase-coupled intramembrane lipid transporter activity|
|phospholipid translocation|
|lipid translocation|
|positive regulation of anion transport|
|regulation of membrane lipid distribution|
|azurophil granule membrane|
|positive regulation of lipid transport|
|positive regulation of lipid localization|
|specific granule membrane|
|phospholipid transport|
|regulation of anion transport|
|regulation of lipid transport|
|organophosphate ester transport|
|regulation of lipid localization|
|learning|
|trans-Golgi network|
|magnesium ion binding|
|learning or memory|
|positive regulation of ion transport|
|lipid transport|
|cognition|
|lipid localization|
|organic anion transport|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|positive regulation of cell migration|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|positive regulation of cell motility|
|myeloid cell activation involved in immune response|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|behavior|
|anion transport|
|myeloid leukocyte activation|
|cation transmembrane transport|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|intracellular membrane-bounded organelle|
|regulation of ion transport|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|cation transport|
|regulation of cell migration|
|membrane organization|
|regulation of cell motility|
|leukocyte activation|
|ion transmembrane transport|
|regulation of locomotion|
|Golgi apparatus|
|positive regulation of transport|
|regulation of cellular component movement|
|secretion by cell|
|endoplasmic reticulum|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|positive regulation of cellular component organization|
|transmembrane transport|
|ion transport|
|nervous system process|
|ATP binding|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12208
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.88 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP8A1 Expression in NALM6 Cells: 8.88'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>