======= ATP8B1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP8B1
  * **<color #00a2e8>Official Name</color>**: ATPase phospholipid transporting 8B1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5205|5205]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43520|O43520]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP8B1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP8B1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602397|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the P-type cation transport ATPase family, which belongs to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Mutations in this gene may result in progressive familial intrahepatic cholestasis type 1 and in benign recurrent intrahepatic cholestasis. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May play a role in asymmetric distribution of phospholipids in the canicular membrane. May have a role in transport of bile acids into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both. In cooperation with ABCB4 may be involved in establishing integrity of the canalicular membrane thus protecting hepatocytes from bile salts. Together with TMEM30A is involved in uptake of the synthetic drug alkylphospholipid perifosine. Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity. Required for the preservation of cochlear hair cells in the inner ear. May act as cardiolipin transporter during inflammatory injury. {ECO:0000269|PubMed:17948906, ECO:0000269|PubMed:20510206, ECO:0000269|PubMed:20512993}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HAD|
|E1-E2 ATPase|
|Hydrolase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|aminophospholipid flippase activity|
|vestibulocochlear nerve formation|
|aminophospholipid translocation|
|regulation of microvillus assembly|
|vestibulocochlear nerve morphogenesis|
|aminophospholipid transport|
|cranial nerve formation|
|vestibulocochlear nerve development|
|cardiolipin binding|
|regulation of microvillus organization|
|ATPase-coupled intramembrane lipid transporter activity|
|bile acid and bile salt transport|
|cranial nerve morphogenesis|
|stereocilium|
|bile acid metabolic process|
|inner ear receptor cell development|
|phospholipid translocation|
|lipid translocation|
|regulation of membrane lipid distribution|
|cranial nerve development|
|inner ear receptor cell differentiation|
|brush border membrane|
|mechanoreceptor differentiation|
|drug transmembrane transport|
|nerve development|
|phospholipid transport|
|organophosphate ester transport|
|Golgi organization|
|monocarboxylic acid transport|
|organic hydroxy compound transport|
|sensory perception of sound|
|drug transport|
|sensory perception of mechanical stimulus|
|inner ear development|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|magnesium ion binding|
|ear development|
|steroid metabolic process|
|organic acid transport|
|carboxylic acid transport|
|lipid transport|
|apical plasma membrane|
|lipid localization|
|endomembrane system organization|
|organic hydroxy compound metabolic process|
|organic anion transport|
|monocarboxylic acid metabolic process|
|sensory organ development|
|anion transport|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|neuron development|
|membrane organization|
|anatomical structure formation involved in morphogenesis|
|carboxylic acid metabolic process|
|ion transmembrane transport|
|regulation of cellular component biogenesis|
|sensory perception|
|Golgi apparatus|
|oxoacid metabolic process|
|neuron differentiation|
|endoplasmic reticulum|
|response to drug|
|organic acid metabolic process|
|negative regulation of transcription, DNA-templated|
|lipid metabolic process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|transmembrane transport|
|negative regulation of RNA metabolic process|
|ion transport|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|integral component of plasma membrane|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|negative regulation of biosynthetic process|
|neurogenesis|
|cell development|
|negative regulation of gene expression|
|small molecule metabolic process|
|nitrogen compound transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12363
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP8B1 Expression in NALM6 Cells: 2.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>