======= ATP8B2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP8B2
  * **<color #00a2e8>Official Name</color>**: ATPase phospholipid transporting 8B2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57198|57198]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P98198|P98198]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP8B2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP8B2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605867|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). {ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HAD|
|E1-E2 ATPase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ATPase-coupled intramembrane lipid transporter activity|
|phospholipid translocation|
|lipid translocation|
|regulation of membrane lipid distribution|
|phospholipid transport|
|organophosphate ester transport|
|Golgi organization|
|magnesium ion binding|
|lipid transport|
|lipid localization|
|endomembrane system organization|
|organic anion transport|
|anion transport|
|membrane organization|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|Golgi apparatus|
|transmembrane transport|
|ion transport|
|ATP binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-5.08|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-4.29|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-3.31|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-3.11|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-3.1|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.89|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-2.82|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.73|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.58|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.53|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.48|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.37|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-2.3|
|[[:results:exp274|Citral 50μM R06 exp274]]|-2.27|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-2.24|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-2.2|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-2.16|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.15|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-2.11|
|[[:results:exp218|A-395 10μM R05 exp218]]|-2.1|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.1|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-2.06|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-2.04|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-2.03|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.98|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.96|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.92|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.91|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.91|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-1.88|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.85|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|-1.85|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.83|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.83|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-1.82|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-1.81|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-1.76|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-1.75|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.7|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.73|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.79|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|1.82|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|1.84|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|1.96|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|2.1|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|2.39|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|2.49|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.94|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|3.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tmem30a|TMEM30A]]|0.513|
|[[:human genes:t:tmem230|TMEM230]]|0.484|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.459|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9297
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP8B2 Expression in NALM6 Cells: 7.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>