======= ATPIF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP5IF1
  * **<color #00a2e8>Official Name</color>**: ATP synthase inhibitory factor subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=93974|93974]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UII2|Q9UII2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATPIF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATPIF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614981|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme. {ECO:0000269|PubMed:12110673, ECO:0000269|PubMed:15528193, ECO:0000269|PubMed:19559621, ECO:0000269|PubMed:23135403}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IATP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial proton-transporting ATP synthase complex binding|
|mitochondrial depolarization|
|angiostatin binding|
|ATPase inhibitor activity|
|positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization|
|regulation of autophagy of mitochondrion in response to mitochondrial depolarization|
|positive regulation of autophagy of mitochondrion|
|response to mitochondrial depolarisation|
|negative regulation of ATPase activity|
|heme biosynthetic process|
|porphyrin-containing compound biosynthetic process|
|tetrapyrrole biosynthetic process|
|enzyme inhibitor activity|
|heme metabolic process|
|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|negative regulation of endothelial cell proliferation|
|porphyrin-containing compound metabolic process|
|regulation of autophagy of mitochondrion|
|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|regulation of protein targeting to mitochondrion|
|pigment biosynthetic process|
|membrane depolarization|
|tetrapyrrole metabolic process|
|pigment metabolic process|
|regulation of mitochondrial membrane potential|
|regulation of mitochondrial membrane permeability|
|regulation of establishment of protein localization to mitochondrion|
|erythrocyte differentiation|
|ATPase binding|
|regulation of ATPase activity|
|regulation of membrane permeability|
|regulation of protein targeting|
|erythrocyte homeostasis|
|protein homotetramerization|
|myeloid cell homeostasis|
|reactive oxygen species metabolic process|
|positive regulation of mitochondrion organization|
|regulation of ATP metabolic process|
|positive regulation of autophagy|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|negative regulation of epithelial cell proliferation|
|mitochondrial membrane organization|
|regulation of endothelial cell proliferation|
|positive regulation of cellular protein catabolic process|
|protein tetramerization|
|positive regulation of apoptotic signaling pathway|
|regulation of mitochondrion organization|
|homeostasis of number of cells|
|calmodulin binding|
|cofactor biosynthetic process|
|mitochondrial transport|
|positive regulation of protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|myeloid cell differentiation|
|regulation of intracellular protein transport|
|regulation of cellular protein catabolic process|
|angiogenesis|
|regulation of autophagy|
|regulation of epithelial cell proliferation|
|protein homooligomerization|
|enzyme binding|
|regulation of intracellular transport|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|regulation of apoptotic signaling pathway|
|blood vessel morphogenesis|
|generation of precursor metabolites and energy|
|regulation of membrane potential|
|positive regulation of catabolic process|
|cofactor metabolic process|
|mitochondrion organization|
|negative regulation of hydrolase activity|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|protein complex oligomerization|
|regulation of cellular protein localization|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|cell surface|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|immune system development|
|positive regulation of programmed cell death|
|tube morphogenesis|
|negative regulation of cell population proliferation|
|positive regulation of cell death|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|negative regulation of catalytic activity|
|regulation of cellular catabolic process|
|tube development|
|membrane organization|
|circulatory system development|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|regulation of cellular localization|
|positive regulation of transport|
|regulation of catabolic process|
|regulation of protein localization|
|negative regulation of molecular function|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of cellular component organization|
|mitochondrion|
|regulation of hydrolase activity|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|protein-containing complex subunit organization|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-1.87|
|[[:results:exp518|RK-33 8μM R08 exp518]]|-1.75|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.7|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.72|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.77|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.77|
|[[:results:exp461|BS-181 20μM R08 exp461]]|1.82|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|2|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|2.12|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7238
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATPIF1 Expression in NALM6 Cells: 5.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>