======= ATXN7L3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATXN7L3
  * **<color #00a2e8>Official Name</color>**: ataxin 7 like 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56970|56970]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14CW9|Q14CW9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATXN7L3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATXN7L3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619010|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B (PubMed:18206972, PubMed:21746879). The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972). Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B (PubMed:27601583). {ECO:0000255|HAMAP-Rule:MF_03047, ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:21746879, ECO:0000269|PubMed:27601583}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sgf11|
|SCA7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DUBm complex|
|SAGA complex|
|histone deubiquitination|
|histone monoubiquitination|
|histone ubiquitination|
|protein monoubiquitination|
|nuclear receptor transcription coactivator activity|
|protein deubiquitination|
|transcription coactivator activity|
|protein modification by small protein removal|
|histone modification|
|covalent chromatin modification|
|protein ubiquitination|
|chromatin organization|
|protein modification by small protein conjugation|
|zinc ion binding|
|protein modification by small protein conjugation or removal|
|chromosome organization|
|proteolysis|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-2.53|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2.37|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-2.32|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.28|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.23|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.17|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.12|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.08|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.08|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.91|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.91|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-1.86|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.82|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.79|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.78|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.76|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.72|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.77|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.78|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.91|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.17|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.22|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.24|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.26|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.35|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.83|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.98|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|3.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:usp22|USP22]]|0.431|
|[[:human genes:c:ccnf|CCNF]]|0.43|
|[[:human genes:d:dek|DEK]]|0.427|
|[[:human genes:h:hectd1|HECTD1]]|0.417|
|[[:human genes:p:ppp1r15b|PPP1R15B]]|0.413|
|[[:human genes:k:kpna2|KPNA2]]|0.405|
|[[:human genes:k:kat2a|KAT2A]]|0.402|
|[[:human genes:t:tada2b|TADA2B]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 20/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/15|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|1/14|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|3/15|
|prostate|1/1|
|skin|1/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1897
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATXN7L3 Expression in NALM6 Cells: 6.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>