======= AURKA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AURKA
  * **<color #00a2e8>Official Name</color>**: aurora kinase A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6790|6790]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14965|O14965]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AURKA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AURKA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603072|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis. {ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:14990569, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19357306, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:9606188}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spindle assembly involved in female meiosis I|
|positive regulation of oocyte maturation|
|spindle assembly involved in female meiosis|
|germinal vesicle|
|positive regulation of oocyte development|
|positive regulation of oogenesis|
|chromosome passenger complex|
|histone serine kinase activity|
|mitotic centrosome separation|
|pronucleus|
|spindle assembly involved in meiosis|
|regulation of oocyte maturation|
|female meiosis I|
|centrosome separation|
|axon hillock|
|positive regulation of cell maturation|
|regulation of oocyte development|
|regulation of oogenesis|
|meiotic spindle|
|histone-serine phosphorylation|
|meiotic spindle organization|
|condensed nuclear chromosome, centromeric region|
|spindle pole centrosome|
|protein localization to centrosome|
|protein localization to microtubule organizing center|
|regulation of cell maturation|
|spindle midzone|
|mitotic spindle pole|
|centrosome localization|
|protein serine/threonine/tyrosine kinase activity|
|histone phosphorylation|
|microtubule organizing center localization|
|liver regeneration|
|female meiotic nuclear division|
|protein localization to microtubule cytoskeleton|
|spindle microtubule|
|protein localization to cytoskeleton|
|anterior/posterior axis specification|
|positive regulation of mitotic nuclear division|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|signal transduction involved in mitotic DNA damage checkpoint|
|signal transduction involved in mitotic DNA integrity checkpoint|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|regulation of centrosome cycle|
|neuron projection extension|
|mitotic G1/S transition checkpoint|
|mitotic G1 DNA damage checkpoint|
|G1 DNA damage checkpoint|
|positive regulation of nuclear division|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in cell cycle checkpoint|
|animal organ regeneration|
|mitotic spindle organization|
|positive regulation of reproductive process|
|DNA damage response, signal transduction by p53 class mediator|
|positive regulation of cell cycle arrest|
|anaphase-promoting complex-dependent catabolic process|
|centrosome cycle|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|axis specification|
|developmental cell growth|
|negative regulation of G2/M transition of mitotic cell cycle|
|regulation of cytokinesis|
|cell growth|
|microtubule organizing center organization|
|mitotic DNA damage checkpoint|
|positive regulation of ubiquitin-dependent protein catabolic process|
|spindle assembly|
|negative regulation of cell cycle G2/M phase transition|
|negative regulation of protein binding|
|negative regulation of G1/S transition of mitotic cell cycle|
|microtubule cytoskeleton organization involved in mitosis|
|mitotic DNA integrity checkpoint|
|signal transduction in response to DNA damage|
|positive regulation of proteasomal protein catabolic process|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|meiosis I|
|meiosis I cell cycle process|
|developmental growth involved in morphogenesis|
|spindle|
|signal transduction by p53 class mediator|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|liver development|
|hepaticobiliary system development|
|female gamete generation|
|G2/M transition of mitotic cell cycle|
|DNA damage checkpoint|
|cell cycle G2/M phase transition|
|positive regulation of cellular protein catabolic process|
|centriole|
|DNA integrity checkpoint|
|mitotic nuclear division|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|meiotic nuclear division|
|microtubule cytoskeleton|
|mitotic cell cycle checkpoint|
|regulation of ubiquitin-dependent protein catabolic process|
|spindle organization|
|regeneration|
|midbody|
|regulation of reproductive process|
|regulation of cell cycle G1/S phase transition|
|meiotic cell cycle process|
|regulation of cell division|
|regulation of mitotic nuclear division|
|negative regulation of binding|
|peptidyl-serine phosphorylation|
|regulation of signal transduction by p53 class mediator|
|regulation of proteasomal protein catabolic process|
|regulation of microtubule cytoskeleton organization|
|regulation of nuclear division|
|cell cycle checkpoint|
|protein autophosphorylation|
|regulation of G2/M transition of mitotic cell cycle|
|peptidyl-serine modification|
|cilium|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|regulation of proteolysis involved in cellular protein catabolic process|
|anterior/posterior pattern specification|
|positive regulation of protein catabolic process|
|regulation of protein binding|
|regulation of microtubule-based process|
|meiotic cell cycle|
|negative regulation of cell cycle phase transition|
|protein kinase activity|
|regulation of cellular protein catabolic process|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|nuclear division|
|positive regulation of cell cycle process|
|regulation of protein stability|
|ubiquitin protein ligase binding|
|negative regulation of mitotic cell cycle|
|organelle fission|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|negative regulation of cell cycle process|
|regionalization|
|proteasomal protein catabolic process|
|cellular process involved in reproduction in multicellular organism|
|positive regulation of proteolysis|
|protein serine/threonine kinase activity|
|histone modification|
|positive regulation of cellular catabolic process|
|covalent chromatin modification|
|regulation of binding|
|positive regulation of cell cycle|
|regulation of protein catabolic process|
|developmental growth|
|growth|
|gland development|
|regulation of mitotic cell cycle phase transition|
|positive regulation of catabolic process|
|pattern specification process|
|regulation of cell cycle phase transition|
|protein kinase binding|
|microtubule cytoskeleton organization|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|protein heterodimerization activity|
|cell projection morphogenesis|
|centrosome|
|cell division|
|positive regulation of multi-organism process|
|cell part morphogenesis|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|modification-dependent macromolecule catabolic process|
|response to wounding|
|negative regulation of cell cycle|
|organelle localization|
|proteolysis involved in cellular protein catabolic process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|neuron projection development|
|microtubule-based process|
|protein catabolic process|
|mitotic cell cycle|
|gamete generation|
|perinuclear region of cytoplasm|
|chromatin organization|
|cell morphogenesis|
|regulation of proteolysis|
|protein localization to organelle|
|regulation of cell cycle process|
|organelle assembly|
|cellular response to DNA damage stimulus|
|regulation of multi-organism process|
|neuron development|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|multicellular organism reproduction|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|cellular macromolecule catabolic process|
|negative regulation of programmed cell death|
|regulation of cell development|
|positive regulation of cell differentiation|
|protein phosphorylation|
|multi-organism reproductive process|
|negative regulation of cell death|
|regulation of catabolic process|
|cell cycle process|
|neuron differentiation|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|chromosome organization|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|proteolysis|
|phosphorylation|
|regulation of organelle organization|
|cell cycle|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|ATP binding|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cell development|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.85|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.73|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.89|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|1.94|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.97|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|2.02|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|2.16|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|2.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.513|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.456|
|[[:human genes:i:ik|IK]]|0.415|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 630/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|27/28|
|bone|24/26|
|breast|27/33|
|central nervous system|49/56|
|cervix|2/4|
|colorectal|14/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|12/16|
|kidney|17/21|
|liver|16/20|
|lung|65/75|
|lymphocyte|14/16|
|ovary|21/26|
|pancreas|19/24|
|peripheral nervous system|14/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|19/24|
|soft tissue|7/9|
|thyroid|1/2|
|upper aerodigestive|15/22|
|urinary tract|21/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1595
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AURKA Expression in NALM6 Cells: 5.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>