======= AURKB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AURKB
  * **<color #00a2e8>Official Name</color>**: aurora kinase B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9212|9212]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96GD4|Q96GD4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AURKB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AURKB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604970|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone H3-S28 phosphorylation|
|mitotic cytokinesis checkpoint|
|histone serine kinase activity|
|chromosome passenger complex|
|abscission|
|cleavage furrow formation|
|negative regulation of cytokinesis|
|mitotic spindle midzone assembly|
|condensed chromosome, centromeric region|
|mitotic spindle elongation|
|spindle elongation|
|spindle midzone assembly|
|histone-serine phosphorylation|
|negative regulation of B cell apoptotic process|
|chromocenter|
|condensed nuclear chromosome, centromeric region|
|mitotic spindle midzone|
|protein localization to kinetochore|
|spindle pole centrosome|
|regulation of B cell apoptotic process|
|negative regulation of cell division|
|protein localization to chromosome, centromeric region|
|positive regulation of telomere capping|
|attachment of spindle microtubules to kinetochore|
|spindle checkpoint|
|mitotic spindle assembly checkpoint|
|spindle assembly checkpoint|
|mitotic spindle checkpoint|
|negative regulation of mitotic metaphase/anaphase transition|
|spindle midzone|
|negative regulation of metaphase/anaphase transition of cell cycle|
|regulation of telomere capping|
|negative regulation of mitotic sister chromatid separation|
|negative regulation of chromosome separation|
|negative regulation of lymphocyte apoptotic process|
|histone phosphorylation|
|protein serine/threonine/tyrosine kinase activity|
|negative regulation of mitotic sister chromatid segregation|
|negative regulation of sister chromatid segregation|
|negative regulation of chromosome segregation|
|positive regulation of telomere maintenance via telomerase|
|positive regulation of telomerase activity|
|cytokinetic process|
|spindle microtubule|
|positive regulation of telomere maintenance via telomere lengthening|
|mitotic spindle assembly|
|positive regulation of cytokinesis|
|negative regulation of mitotic nuclear division|
|negative regulation of leukocyte apoptotic process|
|negative regulation of nuclear division|
|positive regulation of telomere maintenance|
|regulation of telomerase activity|
|regulation of mitotic metaphase/anaphase transition|
|regulation of lymphocyte apoptotic process|
|regulation of metaphase/anaphase transition of cell cycle|
|regulation of telomere maintenance via telomerase|
|regulation of mitotic sister chromatid separation|
|regulation of telomere maintenance via telomere lengthening|
|protein localization to chromosome|
|regulation of chromosome separation|
|positive regulation of DNA biosynthetic process|
|regulation of mitotic sister chromatid segregation|
|mitotic spindle organization|
|regulation of sister chromatid segregation|
|anaphase-promoting complex-dependent catabolic process|
|regulation of leukocyte apoptotic process|
|regulation of telomere maintenance|
|cellular response to UV|
|kinetochore|
|positive regulation of cell division|
|negative regulation of G2/M transition of mitotic cell cycle|
|regulation of cytokinesis|
|kinase binding|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|spindle assembly|
|negative regulation of cell cycle G2/M phase transition|
|regulation of chromosome segregation|
|negative regulation of protein binding|
|microtubule cytoskeleton organization involved in mitosis|
|mitotic sister chromatid segregation|
|regulation of DNA biosynthetic process|
|cellular response to light stimulus|
|spindle|
|negative regulation of chromosome organization|
|plasma membrane invagination|
|sister chromatid segregation|
|response to UV|
|membrane invagination|
|mitotic nuclear division|
|mitotic cell cycle checkpoint|
|spindle organization|
|midbody|
|regulation of cell division|
|regulation of mitotic nuclear division|
|negative regulation of binding|
|positive regulation of chromosome organization|
|cellular response to radiation|
|peptidyl-serine phosphorylation|
|regulation of signal transduction by p53 class mediator|
|regulation of nuclear division|
|cell cycle checkpoint|
|protein autophosphorylation|
|positive regulation of DNA metabolic process|
|regulation of G2/M transition of mitotic cell cycle|
|peptidyl-serine modification|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|regulation of protein binding|
|nuclear chromosome segregation|
|negative regulation of cell cycle phase transition|
|chromosome segregation|
|aging|
|nuclear division|
|positive regulation of cell cycle process|
|response to light stimulus|
|negative regulation of mitotic cell cycle|
|organelle fission|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|negative regulation of cell cycle process|
|regulation of chromosome organization|
|proteasomal protein catabolic process|
|regulation of DNA metabolic process|
|protein serine/threonine kinase activity|
|histone modification|
|negative regulation of organelle organization|
|covalent chromatin modification|
|regulation of binding|
|positive regulation of cell cycle|
|regulation of mitotic cell cycle phase transition|
|response to radiation|
|regulation of cell cycle phase transition|
|microtubule cytoskeleton organization|
|cell division|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|cell population proliferation|
|negative regulation of cell cycle|
|proteolysis involved in cellular protein catabolic process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|positive regulation of transferase activity|
|microtubule-based process|
|protein catabolic process|
|mitotic cell cycle|
|chromatin organization|
|negative regulation of cellular component organization|
|protein localization to organelle|
|regulation of cell cycle process|
|organelle assembly|
|membrane organization|
|negative regulation of transcription by RNA polymerase II|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|cellular macromolecule catabolic process|
|negative regulation of programmed cell death|
|protein phosphorylation|
|regulation of transferase activity|
|negative regulation of cell death|
|cell cycle process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|chromosome organization|
|cytoskeleton organization|
|negative regulation of molecular function|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|proteolysis|
|phosphorylation|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell death|
|negative regulation of gene expression|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp17|DABN 20μM R00 exp17]]|-3.51|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-3.3|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-2.87|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-2.84|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.83|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-2.76|
|[[:results:exp285|GW501516 25μM R06 exp285]]|-2.7|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-2.3|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-2.26|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-2.2|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.18|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-2.17|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|-2.04|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.99|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.99|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-1.96|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.95|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.9|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.89|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.88|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.83|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.74|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.72|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.71|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.71|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.73|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.78|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|1.78|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.85|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|1.86|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.92|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|1.95|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|2.95|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|3.16|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|3.51|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|3.53|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:incenp|INCENP]]|0.471|
|[[:human genes:c:cdca8|CDCA8]]|0.407|
|[[:human genes:e:ect2|ECT2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 718/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/25|
|breast|32/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|20/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|14/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 222
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AURKB Expression in NALM6 Cells: 6.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>