======= AVIL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AVIL
  * **<color #00a2e8>Official Name</color>**: advillin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10677|10677]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75366|O75366]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AVIL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AVIL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613397|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. {ECO:0000269|PubMed:20393563}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|VHP|
|Gelsolin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|actin filament capping|
|negative regulation of actin filament depolymerization|
|regulation of actin filament depolymerization|
|negative regulation of actin filament polymerization|
|negative regulation of protein depolymerization|
|negative regulation of protein polymerization|
|negative regulation of protein complex disassembly|
|regulation of protein depolymerization|
|cell projection|
|regulation of protein complex disassembly|
|negative regulation of protein complex assembly|
|negative regulation of supramolecular fiber organization|
|negative regulation of cytoskeleton organization|
|regulation of actin filament polymerization|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|actin filament binding|
|actin cytoskeleton|
|regulation of protein polymerization|
|regulation of actin filament organization|
|actin binding|
|positive regulation of neuron projection development|
|axon|
|neuron projection|
|regulation of actin cytoskeleton organization|
|cilium assembly|
|regulation of supramolecular fiber organization|
|cilium organization|
|positive regulation of neuron differentiation|
|negative regulation of organelle organization|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|plasma membrane bounded cell projection assembly|
|regulation of protein complex assembly|
|cell projection assembly|
|positive regulation of neurogenesis|
|regulation of neuron projection development|
|regulation of anatomical structure size|
|positive regulation of nervous system development|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|organelle assembly|
|regulation of neurogenesis|
|regulation of nervous system development|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|positive regulation of developmental process|
|generation of neurons|
|neurogenesis|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-2.08|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.73|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.72|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.7|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.86|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7782
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AVIL Expression in NALM6 Cells: 3.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>