======= AVPR1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AVPR1A
  * **<color #00a2e8>Official Name</color>**: arginine vasopressin receptor 1A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=552|552]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P37288|P37288]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AVPR1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AVPR1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600821|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment. {ECO:0000269|PubMed:12082568}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srsx|
|7tm 1|
|DUF1856|
|7TM GPCR Srv|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|V1A vasopressin receptor binding|
|penile erection|
|cellular response to water deprivation|
|maternal aggressive behavior|
|negative regulation of female receptivity|
|positive regulation of cellular pH reduction|
|cellular response to water stimulus|
|regulation of systemic arterial blood pressure by vasopressin|
|regulation of cellular pH reduction|
|sperm ejaculation|
|positive regulation of prostaglandin biosynthetic process|
|negative regulation of transmission of nerve impulse|
|vasopressin receptor activity|
|regulation of female receptivity|
|positive regulation of unsaturated fatty acid biosynthetic process|
|aggressive behavior|
|female mating behavior|
|response to water deprivation|
|regulation of prostaglandin biosynthetic process|
|positive regulation of glutamate secretion|
|regulation of unsaturated fatty acid biosynthetic process|
|insemination|
|parental behavior|
|maternal behavior|
|positive regulation of systemic arterial blood pressure|
|grooming behavior|
|positive regulation of renal sodium excretion|
|response to water|
|copulation|
|regulation of glutamate secretion|
|regulation of transmission of nerve impulse|
|positive regulation of amino acid transport|
|positive regulation of fatty acid biosynthetic process|
|mating behavior|
|response to corticosterone|
|regulation of renal sodium excretion|
|positive regulation of heart rate|
|regulation of excretion|
|negative regulation of nervous system process|
|reproductive behavior|
|positive regulation of vasoconstriction|
|regulation of amino acid transport|
|activation of phospholipase C activity|
|response to mineralocorticoid|
|mating|
|positive regulation of organic acid transport|
|positive regulation of fatty acid metabolic process|
|positive regulation of amine transport|
|regulation of renal system process|
|positive regulation of blood pressure|
|regulation of systemic arterial blood pressure by hormone|
|positive regulation of heart contraction|
|peptide hormone binding|
|positive regulation of phospholipase C activity|
|regulation of fatty acid biosynthetic process|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|regulation of phospholipase C activity|
|endocrine process|
|positive regulation of anion transport|
|social behavior|
|intraspecies interaction between organisms|
|protein kinase C binding|
|regulation of vasoconstriction|
|myotube differentiation|
|regulation of organic acid transport|
|positive regulation of phospholipase activity|
|multi-organism behavior|
|positive regulation of blood circulation|
|regulation of phospholipase activity|
|positive regulation of lipase activity|
|positive regulation of lipid biosynthetic process|
|regulation of intracellular pH|
|regulation of fatty acid metabolic process|
|regulation of cellular pH|
|regulation of systemic arterial blood pressure|
|regulation of amine transport|
|regulation of anion transport|
|regulation of heart rate|
|regulation of lipase activity|
|regulation of pH|
|cellular monovalent inorganic cation homeostasis|
|regulation of nervous system process|
|positive regulation of small molecule metabolic process|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|monovalent inorganic cation homeostasis|
|regulation of tube size|
|positive regulation of lipid metabolic process|
|response to glucocorticoid|
|calcium-mediated signaling|
|response to corticosteroid|
|positive regulation of cell growth|
|vascular process in circulatory system|
|regulation of cellular ketone metabolic process|
|regulation of blood pressure|
|regulation of lipid biosynthetic process|
|response to ketone|
|striated muscle cell differentiation|
|cellular response to acid chemical|
|multi-multicellular organism process|
|response to alcohol|
|regulation of heart contraction|
|muscle cell differentiation|
|telencephalon development|
|positive regulation of growth|
|cellular response to extracellular stimulus|
|endosome|
|positive regulation of ion transport|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|response to steroid hormone|
|regulation of cytosolic calcium ion concentration|
|cellular response to external stimulus|
|second-messenger-mediated signaling|
|response to acid chemical|
|forebrain development|
|blood circulation|
|circulatory system process|
|regulation of lipid metabolic process|
|positive regulation of secretion by cell|
|regulation of cell growth|
|generation of precursor metabolites and energy|
|regulation of small molecule metabolic process|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|muscle structure development|
|divalent inorganic cation homeostasis|
|regulation of anatomical structure size|
|response to extracellular stimulus|
|response to inorganic substance|
|cellular metal ion homeostasis|
|behavior|
|regulation of system process|
|cellular response to hormone stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of growth|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|brain development|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|positive regulation of hydrolase activity|
|head development|
|ion homeostasis|
|regulation of secretion|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|response to lipid|
|cellular homeostasis|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|central nervous system development|
|positive regulation of transport|
|multi-organism reproductive process|
|cellular response to oxygen-containing compound|
|chemical homeostasis|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|regulation of cell population proliferation|
|homeostatic process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13465
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.53 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AVPR1A Expression in NALM6 Cells: 0.53'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>