======= AVPR1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AVPR1B
  * **<color #00a2e8>Official Name</color>**: arginine vasopressin receptor 1B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=553|553]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P47901|P47901]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AVPR1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AVPR1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600264|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|7TM GPCR Srsx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of systemic arterial blood pressure by vasopressin|
|vasopressin receptor activity|
|activation of phospholipase C activity|
|positive regulation of vasoconstriction|
|regulation of systemic arterial blood pressure by hormone|
|positive regulation of phospholipase C activity|
|regulation of phospholipase C activity|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|endocrine process|
|protein kinase C binding|
|regulation of vasoconstriction|
|positive regulation of phospholipase activity|
|positive regulation of blood circulation|
|positive regulation of lipase activity|
|regulation of phospholipase activity|
|regulation of systemic arterial blood pressure|
|regulation of lipase activity|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|vascular process in circulatory system|
|regulation of blood pressure|
|endosome|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|regulation of cytosolic calcium ion concentration|
|blood circulation|
|circulatory system process|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|regulation of anatomical structure size|
|cellular metal ion homeostasis|
|regulation of system process|
|cellular response to hormone stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|positive regulation of hydrolase activity|
|ion homeostasis|
|cellular homeostasis|
|response to hormone|
|chemical homeostasis|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|homeostatic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.89|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.88|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7609
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AVPR1B Expression in NALM6 Cells: -3.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>