======= AXIN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AXIN2
  * **<color #00a2e8>Official Name</color>**: axin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8313|8313]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2T1|Q9Y2T1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AXIN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AXIN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604025|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta- catenin and APC by GSK3B (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RGS|
|Axin b-cat bind|
|DIX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of centromeric sister chromatid cohesion|
|regulation of chondrocyte development|
|regulation of mismatch repair|
|direct ossification|
|intramembranous ossification|
|maintenance of DNA repeat elements|
|heart field specification|
|secondary heart field specification|
|I-SMAD binding|
|beta-catenin destruction complex|
|heart formation|
|specification of animal organ identity|
|regulation of sister chromatid cohesion|
|beta-catenin-TCF complex assembly|
|chondrocyte differentiation involved in endochondral bone morphogenesis|
|animal organ formation|
|negative regulation of osteoblast differentiation|
|mRNA stabilization|
|cartilage development involved in endochondral bone morphogenesis|
|positive regulation of epithelial to mesenchymal transition|
|RNA stabilization|
|bone mineralization|
|regulation of chondrocyte differentiation|
|negative regulation of mRNA catabolic process|
|negative regulation of RNA catabolic process|
|somitogenesis|
|regulation of cartilage development|
|endochondral bone morphogenesis|
|negative regulation of ossification|
|negative regulation of mRNA metabolic process|
|regulation of sister chromatid segregation|
|somite development|
|chondrocyte differentiation|
|beta-catenin binding|
|regulation of epithelial to mesenchymal transition|
|biomineral tissue development|
|biomineralization|
|segmentation|
|regulation of chromosome segregation|
|regulation of osteoblast differentiation|
|bone morphogenesis|
|odontogenesis|
|regulation of DNA repair|
|positive regulation of canonical Wnt signaling pathway|
|cartilage development|
|negative regulation of canonical Wnt signaling pathway|
|positive regulation of Wnt signaling pathway|
|regulation of mRNA stability|
|regulation of RNA stability|
|regulation of ossification|
|bone development|
|regulation of mRNA catabolic process|
|negative regulation of Wnt signaling pathway|
|anterior/posterior pattern specification|
|regulation of response to DNA damage stimulus|
|connective tissue development|
|skeletal system morphogenesis|
|heart morphogenesis|
|negative regulation of cellular catabolic process|
|ossification|
|regulation of canonical Wnt signaling pathway|
|ubiquitin protein ligase binding|
|negative regulation of catabolic process|
|regulation of mRNA metabolic process|
|regionalization|
|enzyme binding|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|pattern specification process|
|centrosome|
|skeletal system development|
|posttranscriptional regulation of gene expression|
|heart development|
|cell population proliferation|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|negative regulation of cell population proliferation|
|positive regulation of cell death|
|negative regulation of cell differentiation|
|regulation of cellular response to stress|
|DNA metabolic process|
|regulation of cell cycle process|
|regulation of cellular catabolic process|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|regulation of catabolic process|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|chromosome organization|
|epithelium development|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|regulation of response to stress|
|protein-containing complex assembly|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.82|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.71|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.417|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5246
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AXIN2 Expression in NALM6 Cells: 2.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>