======= AXL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AXL
  * **<color #00a2e8>Official Name</color>**: AXL receptor tyrosine kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=558|558]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30530|P30530]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AXL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AXL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/109135|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. {ECO:0000269|PubMed:10403904, ECO:0000269|PubMed:11484958, ECO:0000269|PubMed:12364394, ECO:0000269|PubMed:12490074, ECO:0000269|PubMed:15507525, ECO:0000269|PubMed:15733062, ECO:0000269|PubMed:1656220, ECO:0000269|PubMed:18840707}. (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:22673088}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|fn3|
|V-set|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|host cell surface|
|neutrophil clearance|
|positive regulation of pinocytosis|
|negative regulation of dendritic cell apoptotic process|
|myosin heavy chain binding|
|positive regulation of natural killer cell differentiation|
|natural killer cell differentiation|
|regulation of dendritic cell apoptotic process|
|vagina development|
|cellular response to interferon-alpha|
|regulation of pinocytosis|
|neutrophil homeostasis|
|regulation of natural killer cell differentiation|
|female genitalia development|
|positive regulation of natural killer cell activation|
|phosphatidylinositol 3-kinase binding|
|response to interferon-alpha|
|regulation of natural killer cell activation|
|dendritic cell differentiation|
|blood vessel remodeling|
|negative regulation of interferon-gamma production|
|Wnt-protein binding|
|protein kinase B signaling|
|apoptotic cell clearance|
|negative regulation of leukocyte apoptotic process|
|genitalia development|
|positive regulation of cytokine-mediated signaling pathway|
|substrate adhesion-dependent cell spreading|
|transmembrane receptor protein tyrosine kinase activity|
|positive regulation of response to cytokine stimulus|
|natural killer cell activation|
|negative regulation of tumor necrosis factor production|
|phosphatidylserine binding|
|forebrain cell migration|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|vascular endothelial growth factor receptor signaling pathway|
|ovulation cycle|
|leukocyte homeostasis|
|cellular response to hydrogen peroxide|
|animal organ regeneration|
|virus receptor activity|
|regulation of leukocyte apoptotic process|
|protein tyrosine kinase activity|
|erythrocyte homeostasis|
|positive regulation of lymphocyte differentiation|
|viral entry into host cell|
|regulation of interferon-gamma production|
|positive regulation of endocytosis|
|tissue remodeling|
|entry into host|
|entry into host cell|
|female sex differentiation|
|myeloid cell homeostasis|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|neuron migration|
|cellular response to reactive oxygen species|
|platelet activation|
|peptidyl-tyrosine phosphorylation|
|negative regulation of neuron apoptotic process|
|negative regulation of lymphocyte activation|
|peptidyl-tyrosine modification|
|positive regulation of leukocyte differentiation|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|interaction with host|
|regeneration|
|cell maturation|
|regulation of cytokine-mediated signaling pathway|
|positive regulation of protein kinase B signaling|
|regulation of lymphocyte differentiation|
|negative regulation of leukocyte activation|
|regulation of response to cytokine stimulus|
|cell-substrate adhesion|
|cellular response to lipopolysaccharide|
|positive regulation of hemopoiesis|
|cellular response to molecule of bacterial origin|
|response to reactive oxygen species|
|negative regulation of cell activation|
|homeostasis of number of cells|
|viral life cycle|
|receptor complex|
|regulation of endocytosis|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|cellular response to toxic substance|
|cellular response to biotic stimulus|
|regulation of protein kinase B signaling|
|lymphocyte differentiation|
|developmental maturation|
|cellular response to oxidative stress|
|cellular response to extracellular stimulus|
|sex differentiation|
|regulation of leukocyte differentiation|
|negative regulation of cytokine production|
|rhythmic process|
|blood coagulation|
|coagulation|
|hemostasis|
|response to antibiotic|
|regulation of neuron death|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|phagocytosis|
|leukocyte differentiation|
|cellular response to external stimulus|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|positive regulation of lymphocyte activation|
|lymphocyte activation|
|forebrain development|
|response to oxidative stress|
|positive regulation of leukocyte activation|
|cellular response to drug|
|positive regulation of cell activation|
|reproductive structure development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|reproductive system development|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|wound healing|
|protein heterodimerization activity|
|regulation of body fluid levels|
|inflammatory response|
|response to toxic substance|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of lymphocyte activation|
|cellular response to lipid|
|response to extracellular stimulus|
|response to inorganic substance|
|spermatogenesis|
|regulation of vesicle-mediated transport|
|hemopoiesis|
|cell morphogenesis involved in differentiation|
|male gamete generation|
|response to wounding|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|cell surface|
|regulation of cell activation|
|immune system development|
|developmental process involved in reproduction|
|response to bacterium|
|gamete generation|
|regulation of cytokine production|
|viral process|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|brain development|
|innate immune response|
|head development|
|symbiotic process|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|response to lipid|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|central nervous system development|
|positive regulation of transport|
|negative regulation of cell death|
|multi-organism reproductive process|
|secretion by cell|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|response to drug|
|export from cell|
|cellular response to oxygen-containing compound|
|cell activation|
|cell motility|
|localization of cell|
|response to cytokine|
|cell-cell signaling|
|secretion|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|ATP binding|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|extracellular space|
|neurogenesis|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.8|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6658
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AXL Expression in NALM6 Cells: 1.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>