======= AZIN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AZIN1
  * **<color #00a2e8>Official Name</color>**: antizyme inhibitor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51582|51582]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14977|O14977]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AZIN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AZIN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607909|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme- binding (PubMed:17900240, PubMed:26305948). Inhibits antizyme- dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). {ECO:0000269|PubMed:17900240, ECO:0000269|PubMed:26305948}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Orn Arg deC N|
|Orn DAP Arg deC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of polyamine transmembrane transport|
|putrescine biosynthetic process from ornithine|
|ornithine decarboxylase activator activity|
|ornithine decarboxylase activity|
|putrescine biosynthetic process|
|regulation of polyamine transmembrane transport|
|putrescine metabolic process|
|ornithine metabolic process|
|polyamine biosynthetic process|
|polyamine metabolic process|
|cellular biogenic amine biosynthetic process|
|amine biosynthetic process|
|cellular biogenic amine metabolic process|
|cellular amine metabolic process|
|regulation of cellular amino acid metabolic process|
|amine metabolic process|
|regulation of cellular amine metabolic process|
|negative regulation of protein catabolic process|
|regulation of cellular ketone metabolic process|
|ammonium ion metabolic process|
|positive regulation of transmembrane transport|
|alpha-amino acid metabolic process|
|cellular amino acid metabolic process|
|negative regulation of catabolic process|
|regulation of protein catabolic process|
|regulation of small molecule metabolic process|
|regulation of transmembrane transport|
|carboxylic acid metabolic process|
|positive regulation of transport|
|regulation of catabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|negative regulation of protein metabolic process|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|positive regulation of molecular function|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-2.18|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-2.17|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-2.05|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.81|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.72|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.77|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.89|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.21|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.32|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.51|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.57|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|4.15|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|5.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:o:odc1|ODC1]]|0.477|
|[[:human genes:b:brpf1|BRPF1]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3052
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AZIN1 Expression in NALM6 Cells: 6.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>