======= AZU1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AZU1
  * **<color #00a2e8>Official Name</color>**: azurocidin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=566|566]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20160|P20160]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AZU1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AZU1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/162815|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram- negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G. {ECO:0000269|PubMed:1399008, ECO:0000269|PubMed:1937776, ECO:0000269|PubMed:2312733}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Trypsin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of fractalkine biosynthetic process|
|regulation of fractalkine biosynthetic process|
|positive regulation of fractalkine production|
|regulation of fractalkine production|
|neutrophil mediated cytotoxicity|
|neutrophil mediated killing of symbiont cell|
|neutrophil mediated killing of bacterium|
|positive regulation of interleukin-1 biosynthetic process|
|regulation of interleukin-1 beta biosynthetic process|
|positive regulation of interleukin-1 beta biosynthetic process|
|regulation of interleukin-1 biosynthetic process|
|killing by host of symbiont cells|
|monocyte activation|
|disruption by host of symbiont cells|
|positive regulation of MHC class II biosynthetic process|
|azurophil granule|
|toxic substance binding|
|positive regulation of chemokine biosynthetic process|
|killing of cells in other organism involved in symbiotic interaction|
|disruption of cells of other organism involved in symbiotic interaction|
|protein kinase C signaling|
|regulation of MHC class II biosynthetic process|
|macrophage chemotaxis|
|induction of positive chemotaxis|
|regulation of chemokine biosynthetic process|
|heparan sulfate proteoglycan binding|
|macrophage migration|
|positive regulation of tumor necrosis factor biosynthetic process|
|calcium-mediated signaling using intracellular calcium source|
|positive regulation of positive chemotaxis|
|regulation of positive chemotaxis|
|protein kinase C-activating G protein-coupled receptor signaling pathway|
|positive regulation of peptidyl-threonine phosphorylation|
|leukocyte activation involved in inflammatory response|
|microglial cell activation|
|regulation of tumor necrosis factor biosynthetic process|
|regulation of vascular permeability|
|glial cell migration|
|glial cell activation|
|cellular extravasation|
|neuroinflammatory response|
|leukocyte mediated cytotoxicity|
|regulation of peptidyl-threonine phosphorylation|
|disruption of cells of other organism|
|killing of cells of other organism|
|macrophage activation|
|positive regulation of interleukin-1 beta production|
|positive regulation of chemokine production|
|positive regulation of interleukin-1 production|
|azurophil granule membrane|
|extrinsic component of membrane|
|positive regulation of cytokine biosynthetic process|
|positive regulation of phagocytosis|
|modification by host of symbiont morphology or physiology|
|interaction with symbiont|
|regulation of chemokine production|
|regulation of interleukin-1 beta production|
|peptidase activity|
|defense response to Gram-negative bacterium|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|cell killing|
|azurophil granule lumen|
|regulation of interleukin-1 production|
|regulation of phagocytosis|
|regulation of cytokine biosynthetic process|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|antimicrobial humoral response|
|myeloid leukocyte migration|
|positive regulation of chemotaxis|
|leukocyte chemotaxis|
|calcium-mediated signaling|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|modification of morphology or physiology of other organism|
|serine-type endopeptidase activity|
|vascular process in circulatory system|
|heparin binding|
|defense response to virus|
|cell chemotaxis|
|regulation of chemotaxis|
|gliogenesis|
|response to virus|
|defense response to bacterium|
|second-messenger-mediated signaling|
|humoral immune response|
|leukocyte migration|
|blood circulation|
|circulatory system process|
|positive regulation of cell adhesion|
|positive regulation of cytokine production|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|inflammatory response|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|positive regulation of protein kinase activity|
|chemotaxis|
|regulation of vesicle-mediated transport|
|taxis|
|positive regulation of locomotion|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|positive regulation of response to external stimulus|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|positive regulation of transferase activity|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|regulated exocytosis|
|leukocyte mediated immunity|
|symbiotic process|
|exocytosis|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|leukocyte activation|
|defense response to other organism|
|cell migration|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|negative regulation of cell death|
|secretion by cell|
|positive regulation of protein phosphorylation|
|export from cell|
|positive regulation of phosphorylation|
|cell activation|
|cell motility|
|localization of cell|
|immune effector process|
|regulation of response to external stimulus|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of protein modification process|
|proteolysis|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11131
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AZU1 Expression in NALM6 Cells: 1.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>