======= B2M =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: B2M
  * **<color #00a2e8>Official Name</color>**: beta-2-microglobulin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=567|567]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61769|P61769]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=B2M&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20B2M|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/109700|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). {ECO:0000269|PubMed:25356553}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C1-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|
|cellular response to iron(III) ion|
|regulation of transferrin receptor binding|
|positive regulation of ferrous iron binding|
|regulation of ferrous iron binding|
|positive regulation of transferrin receptor binding|
|antigen processing and presentation of exogenous peptide antigen via MHC class Ib|
|negative regulation of forebrain neuron differentiation|
|early endosome lumen|
|regulation of forebrain neuron differentiation|
|response to iron(III) ion|
|MHC class I peptide loading complex|
|regulation of iron ion transport|
|HFE-transferrin receptor complex|
|cellular response to nicotine|
|antigen processing and presentation of peptide antigen via MHC class Ib|
|modulation of age-related behavioral decline|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent|
|amyloid fibril formation|
|positive regulation of receptor binding|
|cellular response to iron ion|
|MHC class I protein complex|
|negative regulation of receptor binding|
|positive regulation of cellular senescence|
|antigen processing and presentation of endogenous peptide antigen via MHC class I|
|antigen processing and presentation of endogenous peptide antigen|
|positive regulation of cell aging|
|antigen processing and presentation via MHC class Ib|
|positive regulation of T cell cytokine production|
|antigen processing and presentation of endogenous antigen|
|regulation of receptor binding|
|positive regulation of T cell mediated cytotoxicity|
|regulation of defense response to virus by virus|
|regulation of T cell cytokine production|
|response to iron ion|
|regulation of T cell mediated cytotoxicity|
|protein refolding|
|regulation of cellular senescence|
|regulation of erythrocyte differentiation|
|T cell differentiation in thymus|
|positive regulation of T cell mediated immunity|
|regulation of cell aging|
|response to nicotine|
|positive regulation of receptor-mediated endocytosis|
|ER to Golgi transport vesicle membrane|
|positive regulation of cytokine production involved in immune response|
|tertiary granule lumen|
|positive regulation of leukocyte mediated cytotoxicity|
|specific granule lumen|
|response to cadmium ion|
|positive regulation of cell killing|
|regulation of T cell mediated immunity|
|iron ion transport|
|interferon-gamma-mediated signaling pathway|
|phagocytic vesicle membrane|
|retina homeostasis|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|regulation of leukocyte mediated cytotoxicity|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|iron ion homeostasis|
|recycling endosome membrane|
|regulation of cytokine production involved in immune response|
|protein homotetramerization|
|positive regulation of protein binding|
|positive regulation of production of molecular mediator of immune response|
|antigen processing and presentation of peptide antigen via MHC class I|
|regulation of receptor-mediated endocytosis|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of endocytosis|
|regulation of cell killing|
|negative regulation of protein binding|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|transition metal ion transport|
|negative regulation of epithelial cell proliferation|
|transition metal ion homeostasis|
|positive regulation of leukocyte mediated immunity|
|T cell differentiation|
|regulation of production of molecular mediator of immune response|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|protein tetramerization|
|regulation of lymphocyte mediated immunity|
|early endosome membrane|
|negative regulation of neuron projection development|
|regulation of adaptive immune response|
|cellular response to interferon-gamma|
|negative regulation of binding|
|antigen processing and presentation of exogenous peptide antigen|
|positive regulation of binding|
|negative regulation of cell projection organization|
|response to interferon-gamma|
|antigen processing and presentation of exogenous antigen|
|tissue homeostasis|
|antigen processing and presentation of peptide antigen|
|cellular response to metal ion|
|regulation of leukocyte mediated immunity|
|regulation of endocytosis|
|cellular response to toxic substance|
|antigen processing and presentation|
|positive regulation of immune effector process|
|regulation of protein binding|
|cellular response to inorganic substance|
|regulation of myeloid cell differentiation|
|negative regulation of neuron differentiation|
|protein folding|
|T cell activation|
|lymphocyte differentiation|
|learning or memory|
|aging|
|negative regulation of neurogenesis|
|cognition|
|endoplasmic reticulum lumen|
|negative regulation of nervous system development|
|multicellular organismal homeostasis|
|response to molecule of bacterial origin|
|leukocyte differentiation|
|negative regulation of cell development|
|regulation of epithelial cell proliferation|
|protein homooligomerization|
|anatomical structure homeostasis|
|response to metal ion|
|regulation of binding|
|lymphocyte activation|
|regulation of metal ion transport|
|external side of plasma membrane|
|cellular response to drug|
|focal adhesion|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|supramolecular fiber organization|
|regulation of immune effector process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of neuron projection development|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|response to toxic substance|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|protein complex oligomerization|
|myeloid cell activation involved in immune response|
|response to inorganic substance|
|regulation of vesicle-mediated transport|
|hemopoiesis|
|behavior|
|myeloid leukocyte activation|
|hematopoietic or lymphoid organ development|
|Golgi membrane|
|metal ion homeostasis|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|metal ion transport|
|immune system development|
|regulation of neuron differentiation|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|response to bacterium|
|regulation of cytokine production|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|viral process|
|regulated exocytosis|
|negative regulation of cellular component organization|
|cation homeostasis|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|regulation of cellular response to stress|
|innate immune response|
|leukocyte mediated immunity|
|symbiotic process|
|ion homeostasis|
|exocytosis|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|cation transport|
|positive regulation of immune response|
|protein homodimerization activity|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|negative regulation of developmental process|
|defense response to other organism|
|Golgi apparatus|
|positive regulation of transport|
|secretion by cell|
|cellular response to cytokine stimulus|
|response to drug|
|export from cell|
|identical protein binding|
|cell activation|
|immune effector process|
|response to cytokine|
|chemical homeostasis|
|secretion|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|ion transport|
|nervous system process|
|regulation of response to stress|
|generation of neurons|
|protein-containing complex assembly|
|extracellular space|
|regulation of cell population proliferation|
|neurogenesis|
|homeostatic process|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16198
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='B2M Expression in NALM6 Cells: 9.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>