======= B4GALNT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: B4GALNT1
  * **<color #00a2e8>Official Name</color>**: beta-1,4-N-acetyl-galactosaminyltransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2583|2583]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q00973|Q00973]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=B4GALNT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20B4GALNT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601873|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4 linkage, resulting in the synthesis of G(M2) and G(D2), respectively. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the biosynthesis of gangliosides GM2, GD2 and GA2. {ECO:0000269|PubMed:1601877}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glycos transf 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity|
|ganglioside biosynthetic process|
|lipid glycosylation|
|ganglioside metabolic process|
|glycosphingolipid biosynthetic process|
|lipid storage|
|ceramide biosynthetic process|
|integral component of Golgi membrane|
|glycosphingolipid metabolic process|
|glycolipid biosynthetic process|
|ceramide metabolic process|
|sphingolipid biosynthetic process|
|glycolipid metabolic process|
|liposaccharide metabolic process|
|membrane lipid biosynthetic process|
|sphingolipid metabolic process|
|maintenance of location|
|lipid modification|
|membrane lipid metabolic process|
|glycosylation|
|lipid localization|
|carbohydrate metabolic process|
|amide biosynthetic process|
|spermatogenesis|
|male gamete generation|
|lipid biosynthetic process|
|Golgi membrane|
|carbohydrate derivative biosynthetic process|
|gamete generation|
|cellular amide metabolic process|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|cellular lipid metabolic process|
|multi-organism reproductive process|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|cellular nitrogen compound biosynthetic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12959
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.53 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='B4GALNT1 Expression in NALM6 Cells: -1.53'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>