======= B4GALT6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: B4GALT6
  * **<color #00a2e8>Official Name</color>**: beta-1,4-galactosyltransferase 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9331|9331]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBX8|Q9UBX8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=B4GALT6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20B4GALT6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604017|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the biosynthesis of glycosphingolipids. {ECO:0000269|PubMed:1551920, ECO:0000269|PubMed:3099851}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Galactosyl T 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lactosylceramide biosynthetic process|
|lactosylceramide metabolic process|
|ganglioside biosynthetic process via lactosylceramide|
|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity|
|ganglioside biosynthetic process|
|galactosyltransferase activity|
|ganglioside metabolic process|
|axon ensheathment in central nervous system|
|central nervous system myelination|
|glycosphingolipid biosynthetic process|
|keratan sulfate biosynthetic process|
|keratan sulfate metabolic process|
|central nervous system neuron axonogenesis|
|neuron maturation|
|oligodendrocyte development|
|ceramide biosynthetic process|
|glycosphingolipid metabolic process|
|glycolipid biosynthetic process|
|oligodendrocyte differentiation|
|central nervous system neuron development|
|ceramide metabolic process|
|sphingolipid biosynthetic process|
|Golgi cisterna membrane|
|glycosaminoglycan biosynthetic process|
|myelination|
|mucopolysaccharide metabolic process|
|glial cell development|
|axon ensheathment|
|ensheathment of neurons|
|aminoglycan biosynthetic process|
|glycolipid metabolic process|
|liposaccharide metabolic process|
|membrane lipid biosynthetic process|
|anatomical structure maturation|
|sphingolipid metabolic process|
|glycosaminoglycan metabolic process|
|cell maturation|
|aminoglycan metabolic process|
|glial cell differentiation|
|central nervous system neuron differentiation|
|sulfur compound biosynthetic process|
|membrane lipid metabolic process|
|gliogenesis|
|developmental maturation|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|sulfur compound metabolic process|
|axonogenesis|
|glycoprotein metabolic process|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|carbohydrate metabolic process|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|amide biosynthetic process|
|cell morphogenesis involved in differentiation|
|lipid biosynthetic process|
|Golgi membrane|
|carbohydrate derivative biosynthetic process|
|neuron projection development|
|cell morphogenesis|
|cellular amide metabolic process|
|neuron development|
|cellular component morphogenesis|
|cellular lipid metabolic process|
|central nervous system development|
|oxoacid metabolic process|
|neuron differentiation|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|generation of neurons|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|cell development|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-2.26|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-1.99|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.71|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.71|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.74|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.76|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17153
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='B4GALT6 Expression in NALM6 Cells: 3.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>