======= BAAT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BAAT
  * **<color #00a2e8>Official Name</color>**: bile acid-CoA:amino acid N-acyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=570|570]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14032|Q14032]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BAAT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BAAT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602938|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a liver enzyme that catalyzes the transfer of C24 bile acids from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates. The bile acid conjugates then act as a detergent in the gastrointestinal tract, which enhances lipid and fat-soluble vitamin absorption. Defects in this gene are a cause of familial hypercholanemia (FHCA). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs. {ECO:0000269|PubMed:12810727, ECO:0000269|PubMed:8034703}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Bile Hydr Trans|
|BAAT C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glycine N-choloyltransferase activity|
|very long chain acyl-CoA hydrolase activity|
|bile acid conjugation|
|long-chain acyl-CoA hydrolase activity|
|medium-chain acyl-CoA hydrolase activity|
|N-acyltransferase activity|
|taurine metabolic process|
|alkanesulfonate metabolic process|
|myristoyl-CoA hydrolase activity|
|palmitoyl-CoA hydrolase activity|
|acyl-CoA hydrolase activity|
|glycine metabolic process|
|transferase activity, transferring acyl groups|
|bile acid biosynthetic process|
|carboxylic ester hydrolase activity|
|bile acid metabolic process|
|serine family amino acid metabolic process|
|peroxisomal matrix|
|protein targeting to peroxisome|
|protein localization to peroxisome|
|establishment of protein localization to peroxisome|
|peroxisomal transport|
|animal organ regeneration|
|peroxisome organization|
|neurotransmitter metabolic process|
|acyl-CoA metabolic process|
|thioester metabolic process|
|peroxisome|
|liver development|
|steroid biosynthetic process|
|hepaticobiliary system development|
|xenobiotic metabolic process|
|ribonucleoside bisphosphate metabolic process|
|nucleoside bisphosphate metabolic process|
|purine nucleoside bisphosphate metabolic process|
|regeneration|
|organic hydroxy compound biosynthetic process|
|monocarboxylic acid biosynthetic process|
|cellular response to xenobiotic stimulus|
|alpha-amino acid metabolic process|
|coenzyme metabolic process|
|steroid metabolic process|
|response to xenobiotic stimulus|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|purine ribonucleotide metabolic process|
|fatty acid metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|regulation of neurotransmitter levels|
|protein targeting|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|gland development|
|establishment of protein localization to organelle|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic hydroxy compound metabolic process|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|nucleobase-containing small molecule metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|protein localization to organelle|
|cellular amide metabolic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|intracellular protein transport|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|small molecule metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.24|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.17|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.96|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.77|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.77|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.75|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12178
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BAAT Expression in NALM6 Cells: 0.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>