======= BAG5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BAG5
  * **<color #00a2e8>Official Name</color>**: BAG cochaperone 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9529|9529]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UL15|Q9UL15]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BAG5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BAG5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603885|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. {ECO:0000250, ECO:0000269|PubMed:20223214}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BAG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of protein refolding|
|negative regulation of protein refolding|
|negative regulation of protein folding|
|regulation of protein folding|
|negative regulation of ubiquitin-protein transferase activity|
|regulation of inclusion body assembly|
|inclusion body|
|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of cellular response to oxidative stress|
|negative regulation of oxidative stress-induced cell death|
|negative regulation of response to oxidative stress|
|negative regulation of ubiquitin-dependent protein catabolic process|
|regulation of ubiquitin-protein transferase activity|
|neuron death|
|negative regulation of proteasomal protein catabolic process|
|regulation of oxidative stress-induced cell death|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|negative regulation of protein ubiquitination|
|regulation of cellular response to oxidative stress|
|regulation of cellular response to heat|
|negative regulation of protein modification by small protein conjugation or removal|
|regulation of response to oxidative stress|
|negative regulation of cellular protein catabolic process|
|negative regulation of intrinsic apoptotic signaling pathway|
|chaperone binding|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|Golgi organization|
|negative regulation of protein catabolic process|
|regulation of ubiquitin-dependent protein catabolic process|
|negative regulation of neuron projection development|
|regulation of intrinsic apoptotic signaling pathway|
|protein stabilization|
|negative regulation of cell projection organization|
|regulation of proteasomal protein catabolic process|
|regulation of protein ubiquitination|
|regulation of proteolysis involved in cellular protein catabolic process|
|negative regulation of apoptotic signaling pathway|
|negative regulation of neuron differentiation|
|regulation of protein modification by small protein conjugation or removal|
|protein folding|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|negative regulation of transferase activity|
|regulation of protein stability|
|negative regulation of neurogenesis|
|ubiquitin protein ligase binding|
|negative regulation of catabolic process|
|negative regulation of nervous system development|
|negative regulation of cell development|
|negative regulation of proteolysis|
|regulation of protein catabolic process|
|regulation of apoptotic signaling pathway|
|endomembrane system organization|
|protein kinase binding|
|regulation of neuron projection development|
|negative regulation of intracellular signal transduction|
|negative regulation of protein modification process|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of proteolysis|
|regulation of cellular response to stress|
|negative regulation of catalytic activity|
|regulation of neurogenesis|
|regulation of cellular catabolic process|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|regulation of catabolic process|
|negative regulation of cell death|
|negative regulation of cellular protein metabolic process|
|cell death|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|mitochondrion|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|neurogenesis|
|regulation of cell death|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp124|GSK343 3μM R03 exp124]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17440
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BAG5 Expression in NALM6 Cells: 6.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>