======= BAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BAP1
  * **<color #00a2e8>Official Name</color>**: BRCA1 associated protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8314|8314]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92560|Q92560]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603089|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'- linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor. {ECO:0000269|PubMed:12485996, ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19117993, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:24703950, ECO:0000269|PubMed:9528852}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase C12|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|macrophage homeostasis|
|PR-DUB complex|
|monoubiquitinated histone H2A deubiquitination|
|monoubiquitinated histone deubiquitination|
|monoubiquitinated protein deubiquitination|
|histone deubiquitination|
|positive regulation of protein targeting to mitochondrion|
|protein K48-linked deubiquitination|
|regulation of cytokine production involved in inflammatory response|
|regulation of protein targeting to mitochondrion|
|thiol-dependent ubiquitinyl hydrolase activity|
|positive regulation of establishment of protein localization to mitochondrion|
|leukocyte homeostasis|
|regulation of establishment of protein localization to mitochondrion|
|peptidase activity|
|regulation of protein targeting|
|myeloid cell homeostasis|
|thiol-dependent ubiquitin-specific protease activity|
|positive regulation of mitochondrion organization|
|positive regulation of intracellular protein transport|
|regulation of mitochondrion organization|
|homeostasis of number of cells|
|positive regulation of intracellular transport|
|regulation of intracellular protein transport|
|protein deubiquitination|
|protein modification by small protein removal|
|positive regulation of cellular protein localization|
|regulation of inflammatory response|
|regulation of intracellular transport|
|histone modification|
|covalent chromatin modification|
|chromatin binding|
|regulation of cell growth|
|positive regulation of protein transport|
|positive regulation of establishment of protein localization|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|response to inorganic substance|
|regulation of cellular protein localization|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|regulation of growth|
|negative regulation of cell population proliferation|
|protein catabolic process|
|regulation of cytokine production|
|chromatin organization|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of defense response|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|regulation of protein localization|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|chromosome organization|
|regulation of response to external stimulus|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|proteolysis|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of cell population proliferation|
|homeostatic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.17|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.93|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-1.84|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-1.81|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.77|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.75|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.81|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.83|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.84|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.86|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|1.87|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.89|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.92|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.96|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.16|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.16|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.17|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.2|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|2.29|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.31|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.39|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.39|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.45|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.46|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.56|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.58|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.64|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.72|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.77|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.91|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|3.13|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nsd1|NSD1]]|0.735|
|[[:human genes:d:dohh|DOHH]]|0.712|
|[[:human genes:i:id3|ID3]]|0.672|
|[[:human genes:r:rptor|RPTOR]]|0.629|
|[[:human genes:c:cbfb|CBFB]]|0.628|
|[[:human genes:r:rnmt|RNMT]]|0.621|
|[[:human genes:d:dpagt1|DPAGT1]]|0.596|
|[[:human genes:t:thg1l|THG1L]]|0.593|
|[[:human genes:a:asxl2|ASXL2]]|0.59|
|[[:human genes:b:bak1|BAK1]]|0.586|
|[[:human genes:c:casp9|CASP9]]|0.581|
|[[:human genes:g:gmppb|GMPPB]]|0.578|
|[[:human genes:a:apaf1|APAF1]]|0.573|
|[[:human genes:g:gfpt1|GFPT1]]|0.557|
|[[:human genes:t:triap1|TRIAP1]]|0.553|
|[[:human genes:h:hccs|HCCS]]|0.552|
|[[:human genes:t:trim28|TRIM28]]|0.551|
|[[:human genes:m:mtor|MTOR]]|0.55|
|[[:human genes:p:pmm2|PMM2]]|0.55|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.543|
|[[:human genes:e:eny2|ENY2]]|0.542|
|[[:human genes:s:ssbp2|SSBP2]]|0.537|
|[[:human genes:c:csnk2b|CSNK2B]]|0.536|
|[[:human genes:a:alg1|ALG1]]|0.535|
|[[:human genes:z:zfx|ZFX]]|0.531|
|[[:human genes:u:uap1|UAP1]]|0.524|
|[[:human genes:s:srp14|SRP14]]|0.521|
|[[:human genes:u:ube2k|UBE2K]]|0.52|
|[[:human genes:p:ppp6c|PPP6C]]|0.52|
|[[:human genes:c:ccdc101|CCDC101]]|0.516|
|[[:human genes:p:plaa|PLAA]]|0.514|
|[[:human genes:c:cycs|CYCS]]|0.513|
|[[:human genes:f:fbxo11|FBXO11]]|0.512|
|[[:human genes:d:diablo|DIABLO]]|0.511|
|[[:human genes:v:vhl|VHL]]|0.508|
|[[:human genes:u:ube2g2|UBE2G2]]|0.504|
|[[:human genes:f:faf2|FAF2]]|0.501|
|[[:human genes:h:hars|HARS]]|0.501|
|[[:human genes:h:hspd1|HSPD1]]|0.498|
|[[:human genes:u:uhrf1|UHRF1]]|0.496|
|[[:human genes:c:cbx3|CBX3]]|0.495|
|[[:human genes:m:mlst8|MLST8]]|0.493|
|[[:human genes:a:alg5|ALG5]]|0.493|
|[[:human genes:t:tle4|TLE4]]|0.493|
|[[:human genes:z:znf592|ZNF592]]|0.491|
|[[:human genes:o:otud5|OTUD5]]|0.488|
|[[:human genes:t:tti1|TTI1]]|0.488|
|[[:human genes:u:ubqln1|UBQLN1]]|0.487|
|[[:human genes:n:nae1|NAE1]]|0.486|
|[[:human genes:s:serf2|SERF2]]|0.485|
|[[:human genes:a:atxn10|ATXN10]]|0.485|
|[[:human genes:m:mbtps2|MBTPS2]]|0.484|
|[[:human genes:r:runx1|RUNX1]]|0.483|
|[[:human genes:a:alg2|ALG2]]|0.481|
|[[:human genes:r:rtcb|RTCB]]|0.479|
|[[:human genes:p:ppa2|PPA2]]|0.479|
|[[:human genes:w:wdr24|WDR24]]|0.478|
|[[:human genes:v:vdac2|VDAC2]]|0.477|
|[[:human genes:x:xpo6|XPO6]]|0.475|
|[[:human genes:v:vezt|VEZT]]|0.475|
|[[:human genes:m:metap2|METAP2]]|0.475|
|[[:human genes:a:alg13|ALG13]]|0.472|
|[[:human genes:r:romo1|ROMO1]]|0.471|
|[[:human genes:m:med23|MED23]]|0.47|
|[[:human genes:d:dr1|DR1]]|0.47|
|[[:human genes:m:med16|MED16]]|0.469|
|[[:human genes:m:mllt1|MLLT1]]|0.468|
|[[:human genes:l:lmo2|LMO2]]|0.468|
|[[:human genes:c:crls1|CRLS1]]|0.468|
|[[:human genes:a:atp5j|ATP5J]]|0.467|
|[[:human genes:o:opa1|OPA1]]|0.467|
|[[:human genes:p:prkrir|PRKRIR]]|0.467|
|[[:human genes:a:aars|AARS]]|0.466|
|[[:human genes:a:adsl|ADSL]]|0.463|
|[[:human genes:d:dad1|DAD1]]|0.461|
|[[:human genes:a:atp2a2|ATP2A2]]|0.461|
|[[:human genes:a:atf7ip|ATF7IP]]|0.459|
|[[:human genes:t:trip12|TRIP12]]|0.457|
|[[:human genes:m:meaf6|MEAF6]]|0.456|
|[[:human genes:s:sec61g|SEC61G]]|0.456|
|[[:human genes:r:rpn1|RPN1]]|0.456|
|[[:human genes:s:ssb|SSB]]|0.456|
|[[:human genes:p:pam16|PAM16]]|0.455|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.454|
|[[:human genes:t:tti2|TTI2]]|0.454|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.453|
|[[:human genes:d:dnajc3|DNAJC3]]|0.452|
|[[:human genes:u:utp23|UTP23]]|0.452|
|[[:human genes:d:dhps|DHPS]]|0.452|
|[[:human genes:t:trnt1|TRNT1]]|0.451|
|[[:human genes:s:scaf8|SCAF8]]|0.451|
|[[:human genes:b:brpf1|BRPF1]]|0.45|
|[[:human genes:c:cct7|CCT7]]|0.449|
|[[:human genes:e:exoc4|EXOC4]]|0.448|
|[[:human genes:m:march5|MARCH5]]|0.448|
|[[:human genes:f:fgfr1op|FGFR1OP]]|0.448|
|[[:human genes:t:ttc4|TTC4]]|0.447|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.446|
|[[:human genes:a:atp5b|ATP5B]]|0.444|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.442|
|[[:human genes:l:ldb1|LDB1]]|0.441|
|[[:human genes:v:vmp1|VMP1]]|0.44|
|[[:human genes:t:tsen54|TSEN54]]|0.437|
|[[:human genes:t:timm13|TIMM13]]|0.437|
|[[:human genes:t:trmt10a|TRMT10A]]|0.437|
|[[:human genes:z:znf608|ZNF608]]|0.437|
|[[:human genes:s:sec63|SEC63]]|0.436|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.436|
|[[:human genes:p:pelo|PELO]]|0.435|
|[[:human genes:p:pfn1|PFN1]]|0.435|
|[[:human genes:m:maml1|MAML1]]|0.435|
|[[:human genes:g:gabpa|GABPA]]|0.434|
|[[:human genes:a:alg6|ALG6]]|0.434|
|[[:human genes:r:rad23b|RAD23B]]|0.434|
|[[:human genes:z:zmym2|ZMYM2]]|0.434|
|[[:human genes:a:atp5o|ATP5O]]|0.434|
|[[:human genes:t:thoc6|THOC6]]|0.43|
|[[:human genes:p:pdap1|PDAP1]]|0.429|
|[[:human genes:s:slc25a26|SLC25A26]]|0.429|
|[[:human genes:b:brd9|BRD9]]|0.428|
|[[:human genes:p:pdpk1|PDPK1]]|0.428|
|[[:human genes:a:actb|ACTB]]|0.427|
|[[:human genes:c:chchd4|CHCHD4]]|0.426|
|[[:human genes:p:ppcs|PPCS]]|0.426|
|[[:human genes:a:atp5h|ATP5H]]|0.425|
|[[:human genes:p:pisd|PISD]]|0.425|
|[[:human genes:s:sox7|SOX7]]|0.424|
|[[:human genes:k:kdsr|KDSR]]|0.424|
|[[:human genes:r:rpe|RPE]]|0.424|
|[[:human genes:t:tp53|TP53]]|0.423|
|[[:human genes:p:pik3r4|PIK3R4]]|0.421|
|[[:human genes:n:nars|NARS]]|0.421|
|[[:human genes:v:vrk1|VRK1]]|0.42|
|[[:human genes:a:ago2|AGO2]]|0.42|
|[[:human genes:c:cmtr1|CMTR1]]|0.42|
|[[:human genes:e:eif1ax|EIF1AX]]|0.419|
|[[:human genes:a:arl14ep|ARL14EP]]|0.419|
|[[:human genes:l:lsm10|LSM10]]|0.419|
|[[:human genes:r:rpp21|RPP21]]|0.418|
|[[:human genes:z:zrsr2|ZRSR2]]|0.418|
|[[:human genes:g:gnb1l|GNB1L]]|0.417|
|[[:human genes:w:wdr59|WDR59]]|0.417|
|[[:human genes:t:taz|TAZ]]|0.417|
|[[:human genes:o:oraov1|ORAOV1]]|0.416|
|[[:human genes:b:bptf|BPTF]]|0.416|
|[[:human genes:t:tamm41|TAMM41]]|0.416|
|[[:human genes:u:ube2l3|UBE2L3]]|0.412|
|[[:human genes:u:ube2j1|UBE2J1]]|0.412|
|[[:human genes:a:alg14|ALG14]]|0.411|
|[[:human genes:t:tmem41b|TMEM41B]]|0.41|
|[[:human genes:s:slc35b1|SLC35B1]]|0.409|
|[[:human genes:p:ppp5c|PPP5C]]|0.409|
|[[:human genes:d:ddx5|DDX5]]|0.408|
|[[:human genes:a:alg9|ALG9]]|0.408|
|[[:human genes:c:cdipt|CDIPT]]|0.408|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.405|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.405|
|[[:human genes:t:tufm|TUFM]]|0.404|
|[[:human genes:h:haus8|HAUS8]]|0.403|
|[[:human genes:s:sp3|SP3]]|0.402|
|[[:human genes:m:med25|MED25]]|0.401|
|[[:human genes:e:eprs|EPRS]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 56/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|3/28|
|bone|2/25|
|breast|7/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|4/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/15|
|kidney|2/21|
|liver|2/20|
|lung|3/75|
|lymphocyte|2/14|
|ovary|1/26|
|pancreas|4/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|4/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 239
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BAP1 Expression in NALM6 Cells: 6.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>