======= BCAP31 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BCAP31
  * **<color #00a2e8>Official Name</color>**: B cell receptor associated protein 31
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10134|10134]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51572|P51572]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BCAP31&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BCAP31|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300398|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the B-cell receptor associated protein 31 superfamily. The encoded protein is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in caspase 8-mediated apoptosis. Microdeletions in this gene are associated with contiguous ABCD1/DXS1375E deletion syndrome (CADDS), a neonatal disorder. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 16. [provided by RefSeq, Jan 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD). Also serves as a cargo receptor for the export of transmembrane proteins. May be involved in CASP8- mediated apoptosis. {ECO:0000269|PubMed:10958671, ECO:0000269|PubMed:18287538, ECO:0000269|PubMed:9396746}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Bap31|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of retrograde protein transport, ER to cytosol|
|positive regulation of ER-associated ubiquitin-dependent protein catabolic process|
|protein localization to endoplasmic reticulum exit site|
|negative regulation of endoplasmic reticulum calcium ion concentration|
|regulation of ER-associated ubiquitin-dependent protein catabolic process|
|positive regulation of mitochondrial calcium ion concentration|
|regulation of retrograde protein transport, ER to cytosol|
|positive regulation of protein exit from endoplasmic reticulum|
|positive regulation of ERAD pathway|
|perinuclear endoplasmic reticulum|
|MHC class I protein binding|
|endoplasmic reticulum calcium ion homeostasis|
|calcium-mediated signaling using intracellular calcium source|
|mitochondrial calcium ion homeostasis|
|regulation of protein exit from endoplasmic reticulum|
|regulation of ERAD pathway|
|integral component of lumenal side of endoplasmic reticulum membrane|
|positive regulation of response to endoplasmic reticulum stress|
|clathrin-coated vesicle|
|positive regulation of intrinsic apoptotic signaling pathway|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|lipid droplet|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|regulation of response to endoplasmic reticulum stress|
|Golgi cisterna membrane|
|antigen processing and presentation of peptide antigen via MHC class I|
|positive regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of proteasomal protein catabolic process|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|protein localization to endoplasmic reticulum|
|positive regulation of cellular protein catabolic process|
|calcium-mediated signaling|
|positive regulation of cysteine-type endopeptidase activity|
|regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of intracellular protein transport|
|regulation of intrinsic apoptotic signaling pathway|
|positive regulation of endopeptidase activity|
|positive regulation of apoptotic signaling pathway|
|regulation of proteasomal protein catabolic process|
|antigen processing and presentation of peptide antigen|
|positive regulation of peptidase activity|
|positive regulation of intracellular transport|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|antigen processing and presentation|
|regulation of intracellular protein transport|
|regulation of cysteine-type endopeptidase activity|
|regulation of cellular protein catabolic process|
|protein-containing complex binding|
|positive regulation of cytosolic calcium ion concentration|
|positive regulation of cellular protein localization|
|regulation of cytosolic calcium ion concentration|
|second-messenger-mediated signaling|
|regulation of intracellular transport|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|Golgi vesicle transport|
|regulation of protein catabolic process|
|regulation of apoptotic signaling pathway|
|regulation of endopeptidase activity|
|positive regulation of protein transport|
|positive regulation of catabolic process|
|cellular calcium ion homeostasis|
|regulation of peptidase activity|
|calcium ion homeostasis|
|positive regulation of establishment of protein localization|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|regulation of cellular protein localization|
|spermatogenesis|
|cellular metal ion homeostasis|
|male gamete generation|
|metal ion homeostasis|
|cellular cation homeostasis|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|gamete generation|
|positive regulation of cell death|
|viral process|
|cation homeostasis|
|regulation of protein transport|
|inorganic ion homeostasis|
|regulation of proteolysis|
|regulation of cellular response to stress|
|protein localization to organelle|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|positive regulation of hydrolase activity|
|symbiotic process|
|ion homeostasis|
|interspecies interaction between organisms|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|multicellular organism reproduction|
|cellular homeostasis|
|regulation of cellular localization|
|apoptotic process|
|endoplasmic reticulum membrane|
|positive regulation of transport|
|regulation of catabolic process|
|multi-organism reproductive process|
|intracellular protein transport|
|endoplasmic reticulum|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|programmed cell death|
|cell death|
|chemical homeostasis|
|mitochondrion|
|regulation of hydrolase activity|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.22|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-1.87|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.87|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.84|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|-1.76|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|1/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18114
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BCAP31 Expression in NALM6 Cells: 6.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>