======= BCAS3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BCAS3
  * **<color #00a2e8>Official Name</color>**: BCAS3 microtubule associated cell migration factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54828|54828]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H6U6|Q9H6U6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BCAS3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BCAS3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607470|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BCAS3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|acetyltransferase activator activity|
|cellular response to estrogen stimulus|
|negative regulation of focal adhesion assembly|
|positive regulation of actin cytoskeleton reorganization|
|regulation of establishment of cell polarity|
|negative regulation of adherens junction organization|
|negative regulation of cell junction assembly|
|regulation of establishment or maintenance of cell polarity|
|transcriptionally active chromatin|
|nuclear hormone receptor binding|
|histone acetyltransferase binding|
|positive regulation of filopodium assembly|
|regulation of actin cytoskeleton reorganization|
|negative regulation of cell-matrix adhesion|
|beta-tubulin binding|
|cell periphery|
|cell leading edge|
|regulation of filopodium assembly|
|negative regulation of GTPase activity|
|intermediate filament cytoskeleton|
|cytoplasmic microtubule|
|regulation of focal adhesion assembly|
|regulation of cell-substrate junction assembly|
|negative regulation of cell-substrate adhesion|
|regulation of adherens junction organization|
|response to estrogen|
|regulation of cell junction assembly|
|microtubule organizing center organization|
|activation of GTPase activity|
|positive regulation of endothelial cell migration|
|positive regulation of plasma membrane bounded cell projection assembly|
|regulation of cell-matrix adhesion|
|histone binding|
|Golgi organization|
|positive regulation of epithelial cell migration|
|tube formation|
|positive regulation of intracellular protein transport|
|regulation of endothelial cell migration|
|response to starvation|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|positive regulation of intracellular transport|
|regulation of cell-substrate adhesion|
|regulation of epithelial cell migration|
|positive regulation of cytoskeleton organization|
|regulation of intracellular protein transport|
|negative regulation of cell adhesion|
|angiogenesis|
|positive regulation of cellular protein localization|
|transcription factor binding|
|regulation of actin cytoskeleton organization|
|regulation of intracellular transport|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|chromatin binding|
|blood vessel morphogenesis|
|positive regulation of GTPase activity|
|endomembrane system organization|
|positive regulation of protein transport|
|negative regulation of hydrolase activity|
|positive regulation of establishment of protein localization|
|microtubule cytoskeleton organization|
|regulation of GTPase activity|
|blood vessel development|
|response to nutrient levels|
|positive regulation of cell migration|
|vasculature development|
|cardiovascular system development|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|response to extracellular stimulus|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|positive regulation of locomotion|
|positive regulation of organelle organization|
|tube morphogenesis|
|microtubule-based process|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of cell projection organization|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|positive regulation of hydrolase activity|
|negative regulation of catalytic activity|
|tube development|
|regulation of cell migration|
|nucleolus|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|regulation of protein localization|
|cytoskeleton organization|
|negative regulation of molecular function|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|regulation of hydrolase activity|
|regulation of organelle organization|
|positive regulation of catalytic activity|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-1.91|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|2.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.425|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18006
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BCAS3 Expression in NALM6 Cells: 3.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>