======= BCL10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BCL10
  * **<color #00a2e8>Official Name</color>**: BCL10 immune signaling adaptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8915|8915]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95999|O95999]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BCL10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BCL10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603517|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF- kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101). {ECO:0000269|PubMed:18264101, ECO:0000269|PubMed:25365219}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CARD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-6 biosynthetic process|
|lymphotoxin A production|
|lymphotoxin A biosynthetic process|
|positive regulation of mast cell cytokine production|
|regulation of mature B cell apoptotic process|
|CBM complex|
|negative regulation of mature B cell apoptotic process|
|regulation of mast cell cytokine production|
|kinase activator activity|
|B cell apoptotic process|
|tumor necrosis factor superfamily cytokine production|
|negative regulation of B cell apoptotic process|
|interleukin-6 production|
|protein kinase B binding|
|positive regulation of interleukin-8 biosynthetic process|
|cytokine biosynthetic process|
|T cell apoptotic process|
|cytokine metabolic process|
|regulation of interleukin-8 biosynthetic process|
|CARD domain binding|
|regulation of B cell apoptotic process|
|lymphocyte apoptotic process|
|positive regulation of myeloid leukocyte cytokine production involved in immune response|
|response to food|
|leukocyte apoptotic process|
|negative regulation of lymphocyte apoptotic process|
|NF-kappaB binding|
|lipopolysaccharide-mediated signaling pathway|
|immunological synapse|
|regulation of T cell receptor signaling pathway|
|negative regulation of leukocyte apoptotic process|
|positive regulation of interleukin-8 production|
|response to fungus|
|positive regulation of extrinsic apoptotic signaling pathway|
|regulation of lymphocyte apoptotic process|
|cytoplasmic microtubule|
|cellular defense response|
|positive regulation of cytokine production involved in immune response|
|protein self-association|
|regulation of antigen receptor-mediated signaling pathway|
|positive regulation of cytokine biosynthetic process|
|regulation of interleukin-8 production|
|I-kappaB kinase/NF-kappaB signaling|
|cellular response to mechanical stimulus|
|regulation of leukocyte apoptotic process|
|regulation of cytokine production involved in immune response|
|neural tube closure|
|tube closure|
|kinase binding|
|positive regulation of production of molecular mediator of immune response|
|primary neural tube formation|
|toll-like receptor signaling pathway|
|protease binding|
|regulation of cytokine biosynthetic process|
|neural tube formation|
|protein heterooligomerization|
|stimulatory C-type lectin receptor signaling pathway|
|positive regulation of protein ubiquitination|
|innate immune response activating cell surface receptor signaling pathway|
|embryonic epithelial tube formation|
|pattern recognition receptor signaling pathway|
|epithelial tube formation|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of protein modification by small protein conjugation or removal|
|regulation of production of molecular mediator of immune response|
|morphogenesis of embryonic epithelium|
|tube formation|
|cytokine production|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of extrinsic apoptotic signaling pathway|
|neural tube development|
|positive regulation of endopeptidase activity|
|Fc-epsilon receptor signaling pathway|
|positive regulation of apoptotic signaling pathway|
|T cell receptor signaling pathway|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|cellular response to lipopolysaccharide|
|protein C-terminus binding|
|positive regulation of peptidase activity|
|cellular response to molecule of bacterial origin|
|regulation of protein ubiquitination|
|positive regulation of T cell activation|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|response to mechanical stimulus|
|cellular response to biotic stimulus|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|membrane raft|
|regulation of protein modification by small protein conjugation or removal|
|innate immune response-activating signal transduction|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|Fc receptor signaling pathway|
|regulation of cysteine-type endopeptidase activity|
|lysosome|
|positive regulation of cell-cell adhesion|
|activation of innate immune response|
|positive regulation of DNA-binding transcription factor activity|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|transcription coactivator activity|
|ubiquitin protein ligase binding|
|antigen receptor-mediated signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|epithelial tube morphogenesis|
|response to lipopolysaccharide|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|regulation of T cell activation|
|response to molecule of bacterial origin|
|transcription factor binding|
|cellular response to external stimulus|
|protein homooligomerization|
|positive regulation of innate immune response|
|enzyme binding|
|positive regulation of proteolysis|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|regulation of cell-cell adhesion|
|regulation of apoptotic signaling pathway|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|regulation of endopeptidase activity|
|positive regulation of cell activation|
|regulation of DNA-binding transcription factor activity|
|morphogenesis of an epithelium|
|negative regulation of immune system process|
|regulation of peptidase activity|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of cytokine production|
|regulation of innate immune response|
|protein kinase binding|
|regulation of immune effector process|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|response to nutrient levels|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|protein complex oligomerization|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|response to extracellular stimulus|
|immune response-activating signal transduction|
|tissue morphogenesis|
|embryonic morphogenesis|
|positive regulation of kinase activity|
|protein-containing complex|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|adaptive immune response|
|activation of immune response|
|chordate embryonic development|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|positive regulation of transferase activity|
|regulation of cell adhesion|
|protein ubiquitination|
|response to bacterium|
|regulation of cytokine production|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|regulation of proteolysis|
|regulation of defense response|
|leukocyte mediated immunity|
|innate immune response|
|positive regulation of hydrolase activity|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|tube development|
|response to lipid|
|positive regulation of immune response|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|apoptotic process|
|defense response to other organism|
|embryo development|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|identical protein binding|
|cell death|
|immune effector process|
|regulation of response to external stimulus|
|epithelium development|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11212
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BCL10 Expression in NALM6 Cells: 3.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>