======= BCL6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BCL6
  * **<color #00a2e8>Official Name</color>**: BCL6 transcription repressor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=604|604]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41182|P41182]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BCL6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BCL6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/109565|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6- binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53- dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH- dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation. {ECO:0000269|PubMed:10981963, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12414651, ECO:0000269|PubMed:12504096, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:15577913, ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23166356, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:9649500}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BTB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of isotype switching to IgE isotypes|
|negative regulation of mast cell cytokine production|
|negative regulation of mitotic cell cycle DNA replication|
|intronic transcription regulatory region sequence-specific DNA binding|
|negative regulation of T-helper 2 cell differentiation|
|negative regulation of nuclear cell cycle DNA replication|
|regulation of mitotic cell cycle DNA replication|
|negative regulation of isotype switching|
|regulation of mast cell cytokine production|
|regulation of isotype switching to IgE isotypes|
|type 2 immune response|
|germinal center formation|
|regulation of memory T cell differentiation|
|regulation of germinal center formation|
|negative regulation of immunoglobulin mediated immune response|
|negative regulation of B cell mediated immunity|
|negative regulation of immunoglobulin production|
|regulation of T-helper 2 cell differentiation|
|negative regulation of B cell apoptotic process|
|negative regulation of type 2 immune response|
|positive regulation of regulatory T cell differentiation|
|negative regulation of T-helper cell differentiation|
|regulation of B cell apoptotic process|
|regulation of nuclear cell cycle DNA replication|
|negative regulation of cellular senescence|
|positive regulation of histone deacetylation|
|negative regulation of CD4-positive, alpha-beta T cell differentiation|
|positive regulation of protein deacetylation|
|negative regulation of Rho protein signal transduction|
|negative regulation of cell aging|
|negative regulation of alpha-beta T cell differentiation|
|replication fork|
|negative regulation of DNA-dependent DNA replication|
|negative regulation of cytokine production involved in immune response|
|regulation of histone deacetylation|
|negative regulation of lymphocyte apoptotic process|
|negative regulation of CD4-positive, alpha-beta T cell activation|
|regulation of type 2 immune response|
|regulation of regulatory T cell differentiation|
|negative regulation of B cell activation|
|erythrocyte development|
|regulation of isotype switching|
|regulation of T-helper cell differentiation|
|negative regulation of production of molecular mediator of immune response|
|negative regulation of cell-matrix adhesion|
|negative regulation of alpha-beta T cell activation|
|negative regulation of lymphocyte mediated immunity|
|negative regulation of DNA replication|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of cellular senescence|
|positive regulation of B cell proliferation|
|negative regulation of Notch signaling pathway|
|negative regulation of T cell differentiation|
|regulation of protein deacetylation|
|negative regulation of adaptive immune response|
|negative regulation of leukocyte apoptotic process|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|negative regulation of DNA recombination|
|regulation of cell aging|
|negative regulation of leukocyte mediated immunity|
|regulation of B cell mediated immunity|
|regulation of immunoglobulin mediated immune response|
|negative regulation of Ras protein signal transduction|
|regulation of lymphocyte apoptotic process|
|negative regulation of lymphocyte differentiation|
|regulation of DNA-dependent DNA replication|
|negative regulation of small GTPase mediated signal transduction|
|myeloid cell development|
|regulation of CD4-positive, alpha-beta T cell activation|
|regulation of B cell proliferation|
|negative regulation of cell-substrate adhesion|
|regulation of alpha-beta T cell differentiation|
|regulation of immunoglobulin production|
|chromatin DNA binding|
|Rho protein signal transduction|
|erythrocyte differentiation|
|positive regulation of T cell differentiation|
|regulation of leukocyte apoptotic process|
|regulation of cytokine production involved in immune response|
|erythrocyte homeostasis|
|positive regulation of histone modification|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|negative regulation of leukocyte differentiation|
|regulation of Notch signaling pathway|
|positive regulation of chromatin organization|
|regulation of DNA recombination|
|myeloid cell homeostasis|
|B cell differentiation|
|regulation of DNA replication|
|negative regulation of T cell activation|
|regulation of cell-matrix adhesion|
|negative regulation of immune effector process|
|negative regulation of DNA metabolic process|
|negative regulation of leukocyte cell-cell adhesion|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte proliferation|
|negative regulation of hemopoiesis|
|regulation of T cell differentiation|
|regulation of production of molecular mediator of immune response|
|regulation of Rho protein signal transduction|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of lymphocyte activation|
|regulation of histone modification|
|positive regulation of leukocyte differentiation|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|B cell activation|
|regulation of adaptive immune response|
|positive regulation of B cell activation|
|regulation of lymphocyte differentiation|
|negative regulation of leukocyte activation|
|positive regulation of chromosome organization|
|negative regulation of cell-cell adhesion|
|negative regulation of cell growth|
|positive regulation of hemopoiesis|
|regulation of chromatin organization|
|negative regulation of cell activation|
|homeostasis of number of cells|
|positive regulation of T cell activation|
|regulation of leukocyte mediated immunity|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of cell-substrate adhesion|
|positive regulation of leukocyte cell-cell adhesion|
|myeloid cell differentiation|
|regulation of leukocyte proliferation|
|lymphocyte differentiation|
|regulation of Ras protein signal transduction|
|negative regulation of growth|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|Ras protein signal transduction|
|positive regulation of cell-cell adhesion|
|regulation of leukocyte differentiation|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of leukocyte cell-cell adhesion|
|negative regulation of mitotic cell cycle|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|regulation of T cell activation|
|small GTPase mediated signal transduction|
|negative regulation of cell cycle process|
|leukocyte differentiation|
|regulation of inflammatory response|
|regulation of small GTPase mediated signal transduction|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|positive regulation of lymphocyte activation|
|positive regulation of neuron differentiation|
|lymphocyte activation|
|chromatin binding|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|regulation of cell growth|
|positive regulation of cell activation|
|sequence-specific DNA binding|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|regulation of immune effector process|
|positive regulation of neurogenesis|
|regulation of GTPase activity|
|actin cytoskeleton organization|
|inflammatory response|
|negative regulation of intracellular signal transduction|
|regulation of lymphocyte activation|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|spermatogenesis|
|hemopoiesis|
|male gamete generation|
|actin filament-based process|
|negative regulation of cell cycle|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|regulation of cell activation|
|positive regulation of apoptotic process|
|immune system development|
|positive regulation of programmed cell death|
|regulation of neuron differentiation|
|regulation of growth|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|DNA-binding transcription factor activity|
|regulation of cell adhesion|
|gamete generation|
|regulation of cytokine production|
|positive regulation of cell death|
|negative regulation of cell differentiation|
|cell morphogenesis|
|regulation of cellular response to stress|
|regulation of cell cycle process|
|regulation of defense response|
|cellular response to DNA damage stimulus|
|regulation of neurogenesis|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|Golgi apparatus|
|regulation of cellular component movement|
|multi-organism reproductive process|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|cell activation|
|regulation of response to external stimulus|
|response to cytokine|
|cytoskeleton organization|
|regulation of immune response|
|positive regulation of immune system process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|cell development|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.82|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.8|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.03|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.85|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.7|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|1.78|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|3.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:itfg2|ITFG2]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13972
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BCL6 Expression in NALM6 Cells: 5.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>