======= BID =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BID
  * **<color #00a2e8>Official Name</color>**: BH3 interacting domain death agonist
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=637|637]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55957|P55957]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BID&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BID|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601997|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2. {ECO:0000250, ECO:0000269|PubMed:14583606}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BID|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of fibroblast apoptotic process|
|integral component of mitochondrial membrane|
|positive regulation of protein homooligomerization|
|positive regulation of mitochondrial membrane potential|
|hepatocyte apoptotic process|
|mitochondrial outer membrane permeabilization|
|positive regulation of membrane potential|
|death receptor binding|
|positive regulation of mitochondrial membrane permeability involved in apoptotic process|
|regulation of fibroblast apoptotic process|
|mitochondrial outer membrane permeabilization involved in programmed cell death|
|regulation of protein homooligomerization|
|positive regulation of mitochondrial membrane permeability|
|release of cytochrome c from mitochondria|
|regulation of mitochondrial membrane permeability involved in apoptotic process|
|positive regulation of membrane permeability|
|positive regulation of protein oligomerization|
|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|epithelial cell apoptotic process|
|positive regulation of release of cytochrome c from mitochondria|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|extrinsic apoptotic signaling pathway via death domain receptors|
|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|regulation of protein oligomerization|
|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|neuron apoptotic process|
|regulation of release of cytochrome c from mitochondria|
|positive regulation of extrinsic apoptotic signaling pathway|
|neuron death|
|positive regulation of establishment of protein localization to mitochondrion|
|positive regulation of intrinsic apoptotic signaling pathway|
|protein targeting to mitochondrion|
|apoptotic mitochondrial changes|
|establishment of protein localization to mitochondrion|
|regulation of mitochondrial membrane potential|
|regulation of mitochondrial membrane permeability|
|regulation of establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|negative regulation of response to DNA damage stimulus|
|regulation of membrane permeability|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|negative regulation of intrinsic apoptotic signaling pathway|
|extrinsic apoptotic signaling pathway|
|signal transduction in response to DNA damage|
|respiratory electron transport chain|
|positive regulation of mitochondrion organization|
|oxidative phosphorylation|
|positive regulation of protein localization to membrane|
|mitochondrial membrane organization|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of cysteine-type endopeptidase activity|
|regulation of extrinsic apoptotic signaling pathway|
|regulation of intrinsic apoptotic signaling pathway|
|mitochondrial outer membrane|
|regulation of cell cycle G1/S phase transition|
|cellular respiration|
|positive regulation of endopeptidase activity|
|positive regulation of apoptotic signaling pathway|
|regulation of mitochondrion organization|
|electron transport chain|
|regulation of protein localization to membrane|
|positive regulation of peptidase activity|
|ATP metabolic process|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|mitochondrial transport|
|regulation of response to DNA damage stimulus|
|negative regulation of apoptotic signaling pathway|
|energy derivation by oxidation of organic compounds|
|regulation of cysteine-type endopeptidase activity|
|positive regulation of protein complex assembly|
|establishment of protein localization to membrane|
|apoptotic signaling pathway|
|ubiquitin protein ligase binding|
|positive regulation of cellular protein localization|
|protein homooligomerization|
|positive regulation of proteolysis|
|protein targeting|
|regulation of apoptotic signaling pathway|
|regulation of mitotic cell cycle phase transition|
|regulation of endopeptidase activity|
|generation of precursor metabolites and energy|
|regulation of membrane potential|
|establishment of protein localization to organelle|
|mitochondrion organization|
|regulation of peptidase activity|
|regulation of cell cycle phase transition|
|regulation of protein complex assembly|
|positive regulation of establishment of protein localization|
|protein localization to membrane|
|protein heterodimerization activity|
|negative regulation of intracellular signal transduction|
|protein complex oligomerization|
|positive regulation of cellular component biogenesis|
|regulation of cellular protein localization|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|regulation of proteolysis|
|regulation of cellular response to stress|
|protein localization to organelle|
|regulation of establishment of protein localization|
|regulation of cell cycle process|
|positive regulation of hydrolase activity|
|cellular response to DNA damage stimulus|
|membrane organization|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|apoptotic process|
|regulation of cellular component biogenesis|
|oxidation-reduction process|
|positive regulation of transport|
|intracellular protein transport|
|negative regulation of cell death|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|programmed cell death|
|cell death|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|mitochondrion|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|1.71|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.5|
|[[:human genes:p:polr2j3|POLR2J3]]|0.47|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.432|
|[[:human genes:r:rrm1|RRM1]]|0.425|
|[[:human genes:t:twistnb|TWISTNB]]|0.424|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.418|
|[[:human genes:v:vasn|VASN]]|0.415|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.414|
|[[:human genes:c:chd4|CHD4]]|0.414|
|[[:human genes:n:nupl1|NUPL1]]|0.412|
|[[:human genes:n:narfl|NARFL]]|0.408|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.407|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.407|
|[[:human genes:o:orc1|ORC1]]|0.407|
|[[:human genes:s:slc7a6os|SLC7A6OS]]|0.407|
|[[:human genes:p:psmb4|PSMB4]]|0.406|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.406|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.404|
|[[:human genes:r:rps2|RPS2]]|0.404|
|[[:human genes:t:tceb3c|TCEB3C]]|0.403|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.401|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3239
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BID Expression in NALM6 Cells: 5.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>