======= BIRC3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BIRC3
  * **<color #00a2e8>Official Name</color>**: baculoviral IAP repeat containing 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=330|330]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13489|Q13489]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BIRC3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BIRC3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601721|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase- independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. {ECO:0000269|PubMed:21931591, ECO:0000269|PubMed:23453969}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BIR|
|CARD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|inhibition of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of nucleotide-binding oligomerization domain containing signaling pathway|
|negative regulation of necroptotic process|
|inhibition of cysteine-type endopeptidase activity|
|zymogen inhibition|
|negative regulation of programmed necrotic cell death|
|negative regulation of necrotic cell death|
|regulation of necroptotic process|
|regulation of RIG-I signaling pathway|
|regulation of programmed necrotic cell death|
|regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|
|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|
|regulation of necrotic cell death|
|TRIF-dependent toll-like receptor signaling pathway|
|MyD88-independent toll-like receptor signaling pathway|
|negative regulation of protein maturation|
|negative regulation of protein processing|
|regulation of tumor necrosis factor-mediated signaling pathway|
|transferase activity|
|regulation of protein processing|
|regulation of toll-like receptor signaling pathway|
|regulation of protein maturation|
|I-kappaB kinase/NF-kappaB signaling|
|regulation of defense response to virus|
|NIK/NF-kappaB signaling|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of cysteine-type endopeptidase activity|
|toll-like receptor signaling pathway|
|protein heterooligomerization|
|positive regulation of protein ubiquitination|
|tumor necrosis factor-mediated signaling pathway|
|pattern recognition receptor signaling pathway|
|positive regulation of protein modification by small protein conjugation or removal|
|regulation of cytokine-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of protein ubiquitination|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|ubiquitin protein ligase activity|
|membrane raft|
|regulation of protein modification by small protein conjugation or removal|
|innate immune response-activating signal transduction|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|cellular response to tumor necrosis factor|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|ubiquitin-protein transferase activity|
|negative regulation of peptidase activity|
|activation of innate immune response|
|response to tumor necrosis factor|
|protein deubiquitination|
|protein modification by small protein removal|
|regulation of inflammatory response|
|positive regulation of innate immune response|
|negative regulation of proteolysis|
|positive regulation of response to biotic stimulus|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|regulation of innate immune response|
|negative regulation of hydrolase activity|
|regulation of immune effector process|
|positive regulation of defense response|
|positive regulation of multi-organism process|
|protein complex oligomerization|
|regulation of response to biotic stimulus|
|spermatogenesis|
|immune response-activating signal transduction|
|male gamete generation|
|immune response-regulating signaling pathway|
|protein-containing complex|
|positive regulation of response to external stimulus|
|activation of immune response|
|cytokine-mediated signaling pathway|
|protein ubiquitination|
|gamete generation|
|regulation of cytokine production|
|regulation of proteolysis|
|regulation of defense response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|positive regulation of immune response|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|multi-organism reproductive process|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of protein modification process|
|proteolysis|
|regulation of hydrolase activity|
|reproductive process|
|reproduction|
|regulation of response to stress|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.82|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.76|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.81|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.94|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.98|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14905
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BIRC3 Expression in NALM6 Cells: 1.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>