======= BLNK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BLNK
  * **<color #00a2e8>Official Name</color>**: B cell linker
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29760|29760]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WV28|Q8WV28]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BLNK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BLNK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604515|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]. COMPLETENESS: complete on the 3' end. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR- mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis. {ECO:0000269|PubMed:10583958, ECO:0000269|PubMed:15270728, ECO:0000269|PubMed:16912232, ECO:0000269|PubMed:9697839}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transmembrane receptor protein tyrosine kinase adaptor activity|
|SH3/SH2 adaptor activity|
|cytoplasmic ribonucleoprotein granule|
|B cell differentiation|
|B cell activation|
|lymphocyte differentiation|
|leukocyte differentiation|
|humoral immune response|
|lymphocyte activation|
|inflammatory response|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|enzyme linked receptor protein signaling pathway|
|leukocyte activation|
|cell activation|
|defense response|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-2.57|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-2.07|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.06|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.95|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.92|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.87|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.84|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.84|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.83|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.8|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.79|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.74|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.84|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.91|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.93|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:btk|BTK]]|0.6|
|[[:human genes:r:rrm1|RRM1]]|0.479|
|[[:human genes:n:nck1|NCK1]]|0.472|
|[[:human genes:p:plcg2|PLCG2]]|0.45|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6272
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BLNK Expression in NALM6 Cells: 6.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>