======= BMP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BMP1
  * **<color #00a2e8>Official Name</color>**: bone morphogenetic protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=649|649]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13497|P13497]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BMP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BMP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/112264|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. [provided by RefSeq, Aug 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EGF CA|
|Astacin|
|CUB|
|cEGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|high-density lipoprotein particle assembly|
|cartilage condensation|
|cell aggregation|
|plasma lipoprotein particle assembly|
|protein-lipid complex assembly|
|positive regulation of cartilage development|
|plasma lipoprotein particle organization|
|protein-lipid complex subunit organization|
|metallopeptidase activity|
|extracellular matrix disassembly|
|regulation of cartilage development|
|regulation of plasma lipoprotein particle levels|
|peptidase activity|
|metalloendopeptidase activity|
|vesicle|
|growth factor activity|
|cartilage development|
|cytokine activity|
|connective tissue development|
|skeletal system morphogenesis|
|ossification|
|extracellular matrix organization|
|extracellular structure organization|
|cellular component disassembly|
|skeletal system development|
|calcium ion binding|
|zinc ion binding|
|animal organ morphogenesis|
|Golgi apparatus|
|identical protein binding|
|proteolysis|
|positive regulation of developmental process|
|protein-containing complex assembly|
|extracellular space|
|positive regulation of multicellular organismal process|
|tissue development|
|protein-containing complex subunit organization|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5623
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BMP1 Expression in NALM6 Cells: 3.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>