======= BMP10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BMP10
  * **<color #00a2e8>Official Name</color>**: bone morphogenetic protein 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27302|27302]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95393|O95393]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BMP10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BMP10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608748|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation. [provided by RefSeq, Aug 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. {ECO:0000269|PubMed:16049014, ECO:0000269|PubMed:17068149, ECO:0000269|PubMed:20608934}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TGFb propeptide|
|TGF beta|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of sarcomere organization|
|atrial cardiac muscle tissue morphogenesis|
|receptor serine/threonine kinase binding|
|positive regulation of cell proliferation involved in heart morphogenesis|
|atrial cardiac muscle tissue development|
|regulation of sarcomere organization|
|telethonin binding|
|regulation of cardiac muscle adaptation|
|regulation of cardiac muscle hypertrophy in response to stress|
|ventricular cardiac muscle cell development|
|heart trabecula formation|
|pathway-restricted SMAD protein phosphorylation|
|cardiac muscle cell proliferation|
|adult heart development|
|striated muscle cell proliferation|
|ventricular cardiac muscle cell differentiation|
|regulation of cell proliferation involved in heart morphogenesis|
|muscle cell proliferation|
|trabecula formation|
|activin receptor signaling pathway|
|positive regulation of cardiac muscle cell proliferation|
|negative regulation of cardiac muscle hypertrophy|
|cardiac muscle tissue growth|
|heart growth|
|negative regulation of muscle hypertrophy|
|cardiac atrium morphogenesis|
|positive regulation of cardiac muscle hypertrophy|
|positive regulation of muscle hypertrophy|
|heart trabecula morphogenesis|
|positive regulation of cardiac muscle tissue growth|
|positive regulation of cartilage development|
|cardiac atrium development|
|positive regulation of heart growth|
|regulation of heart morphogenesis|
|regulation of cardiac muscle cell proliferation|
|transforming growth factor beta receptor binding|
|positive regulation of cardiac muscle tissue development|
|trabecula morphogenesis|
|sarcomere organization|
|positive regulation of organ growth|
|positive regulation of pathway-restricted SMAD protein phosphorylation|
|ventricular cardiac muscle tissue morphogenesis|
|negative regulation of endothelial cell migration|
|ventricular cardiac muscle tissue development|
|SMAD protein signal transduction|
|regulation of cardiac muscle hypertrophy|
|regulation of cardiac muscle tissue growth|
|positive regulation of striated muscle cell differentiation|
|regulation of muscle hypertrophy|
|cardiac muscle cell development|
|regulation of pathway-restricted SMAD protein phosphorylation|
|regulation of heart growth|
|cardiac cell development|
|myofibril assembly|
|negative regulation of epithelial cell migration|
|cardiac muscle tissue morphogenesis|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle organ development|
|regulation of cartilage development|
|positive regulation of muscle tissue development|
|cardiac ventricle morphogenesis|
|positive regulation of organelle assembly|
|regulation of cardiac muscle contraction|
|regulation of cardiac muscle tissue development|
|muscle tissue morphogenesis|
|positive regulation of animal organ morphogenesis|
|regulation of muscle adaptation|
|muscle organ morphogenesis|
|positive regulation of muscle cell differentiation|
|cardiac muscle cell differentiation|
|regulation of actomyosin structure organization|
|BMP signaling pathway|
|regulation of striated muscle contraction|
|regulation of organ growth|
|organ growth|
|hormone activity|
|regulation of striated muscle cell differentiation|
|cellular component assembly involved in morphogenesis|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|response to BMP|
|cellular response to BMP stimulus|
|actomyosin structure organization|
|cardiocyte differentiation|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|regulation of striated muscle tissue development|
|Z disc|
|striated muscle cell development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|muscle cell development|
|regulation of muscle cell differentiation|
|regulation of endothelial cell migration|
|regulation of muscle contraction|
|cardiac muscle tissue development|
|growth factor activity|
|cardiac chamber development|
|positive regulation of developmental growth|
|cytokine activity|
|negative regulation of cell growth|
|positive regulation of supramolecular fiber organization|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|striated muscle cell differentiation|
|regulation of epithelial cell migration|
|regulation of organelle assembly|
|positive regulation of cytoskeleton organization|
|regulation of muscle system process|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of growth|
|regulation of heart contraction|
|muscle cell differentiation|
|heart morphogenesis|
|regulation of animal organ morphogenesis|
|positive regulation of growth|
|negative regulation of cell migration|
|negative regulation of cell motility|
|striated muscle tissue development|
|regulation of blood circulation|
|muscle organ development|
|muscle tissue development|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|regulation of developmental growth|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of actin filament-based process|
|developmental growth|
|growth|
|regulation of cell growth|
|supramolecular fiber organization|
|muscle structure development|
|actin cytoskeleton organization|
|cellular response to growth factor stimulus|
|positive regulation of cellular component biogenesis|
|heart development|
|response to growth factor|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|cell population proliferation|
|tissue morphogenesis|
|actin filament-based process|
|regulation of system process|
|cell surface|
|positive regulation of organelle organization|
|regulation of growth|
|enzyme linked receptor protein signaling pathway|
|regulation of MAPK cascade|
|organelle assembly|
|cellular component morphogenesis|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|regulation of organelle organization|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp135|MS023 7μM R03 exp135]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14089
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BMP10 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>