======= BMPER =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BMPER
  * **<color #00a2e8>Official Name</color>**: BMP binding endothelial regulator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=168667|168667]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N8U9|Q8N8U9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BMPER&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BMPER|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608699|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of the chondrogenic cells. Mutations in this gene are associated with a lethal skeletal disorder, diaphanospondylodysostosis. [provided by RefSeq, Dec 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes. {ECO:0000269|PubMed:14766204}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|VWC|
|C8|
|VWD|
|TIL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|
|endothelial cell activation|
|endothelial cell proliferation|
|positive regulation of sprouting angiogenesis|
|negative regulation of BMP signaling pathway|
|sprouting angiogenesis|
|regulation of pathway-restricted SMAD protein phosphorylation|
|regulation of sprouting angiogenesis|
|ureteric bud development|
|mesonephric tubule development|
|mesonephric epithelium development|
|epithelial cell proliferation|
|regulation of BMP signaling pathway|
|mesonephros development|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|kidney epithelium development|
|negative regulation of cellular response to growth factor stimulus|
|regulation of endothelial cell migration|
|positive regulation of angiogenesis|
|positive regulation of vasculature development|
|inner ear development|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of epithelial cell migration|
|ear development|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|kidney development|
|regulation of cellular response to growth factor stimulus|
|renal system development|
|regulation of angiogenesis|
|regulation of ERK1 and ERK2 cascade|
|angiogenesis|
|urogenital system development|
|regulation of vasculature development|
|blood vessel morphogenesis|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|positive regulation of MAPK cascade|
|sensory organ development|
|cell population proliferation|
|tube morphogenesis|
|regulation of MAPK cascade|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|epithelium development|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-1.77|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-1.76|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.72|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.14|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.35|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.52|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.72|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|3.46|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|3.49|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|3.51|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|4.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13285
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.47 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BMPER Expression in NALM6 Cells: 1.47'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>