======= BOK =======
== Gene Information ==
* **Official Symbol**: BOK
* **Official Name**: BCL2 family apoptosis regulator BOK
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=666|666]]
* **UniProt**: [[https://www.uniprot.org/uniprot/Q9UMX3|Q9UMX3]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=BOK&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BOK|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/605404|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular processes. Studies in rat show that this protein has restricted expression in reproductive tissues, interacts strongly with some antiapoptotic BCL2 proteins, not at all with proapoptotic BCL2 proteins, and induces apoptosis in transfected cells. Thus, this protein represents a proapoptotic member of the BCL2 family. [provided by RefSeq, Sep 2011].
* **UniProt Summary**: Isoform 1: Apoptosis regulator that functions through different apoptotic signaling pathways (PubMed:27076518, PubMed:15102863, PubMed:20673843). Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner (PubMed:27076518, PubMed:15102863). In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival- promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release (PubMed:27076518). In response to DNA damage, mediates intrinsic apoptotic process in a TP53- dependent manner (PubMed:15102863). Plays a role in granulosa cell apoptosis by CASP3 activation (PubMed:20673843). Plays a roles as anti-apoptotic protein during neuronal apoptotic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation (By similarity). In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression (PubMed:19942931). May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1 (PubMed:24113155). {ECO:0000250|UniProtKB:O35425, ECO:0000269|PubMed:15102863, ECO:0000269|PubMed:19942931, ECO:0000269|PubMed:20673843, ECO:0000269|PubMed:24113155, ECO:0000269|PubMed:27076518}.
|Bcl-2|
|regulation of granulosa cell apoptotic process|
|positive regulation of PERK-mediated unfolded protein response|
|BH domain binding|
|cis-Golgi network membrane|
|regulation of chorionic trophoblast cell proliferation|
|negative regulation of mitochondrial depolarization|
|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|
|negative regulation of membrane depolarization|
|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|regulation of PERK-mediated unfolded protein response|
|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|negative regulation of necroptotic process|
|negative regulation of programmed necrotic cell death|
|positive regulation of endoplasmic reticulum unfolded protein response|
|positive regulation of execution phase of apoptosis|
|negative regulation of necrotic cell death|
|regulation of necroptotic process|
|regulation of programmed necrotic cell death|
|regulation of mitochondrial depolarization|
|release of cytochrome c from mitochondria|
|regulation of endoplasmic reticulum unfolded protein response|
|nuclear outer membrane|
|cellular component disassembly involved in execution phase of apoptosis|
|regulation of necrotic cell death|
|signal transduction in absence of ligand|
|extrinsic apoptotic signaling pathway in absence of ligand|
|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|positive regulation of response to endoplasmic reticulum stress|
|regulation of execution phase of apoptosis|
|neuron apoptotic process|
|regulation of membrane depolarization|
|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|intrinsic apoptotic signaling pathway by p53 class mediator|
|neuron death|
|negative regulation of mitochondrion organization|
|execution phase of apoptosis|
|positive regulation of intrinsic apoptotic signaling pathway|
|apoptotic mitochondrial changes|
|oligodendrocyte differentiation|
|regulation of mitochondrial membrane potential|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|regulation of mitochondrial membrane permeability|
|regulation of epithelial cell apoptotic process|
|regulation of membrane permeability|
|recycling endosome membrane|
|regulation of response to endoplasmic reticulum stress|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|trans-Golgi network membrane|
|extrinsic apoptotic signaling pathway|
|mitochondrial membrane|
|positive regulation of mitochondrion organization|
|signal transduction by p53 class mediator|
|mitochondrial membrane organization|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|male gonad development|
|development of primary male sexual characteristics|
|negative regulation of neuron apoptotic process|
|intrinsic apoptotic signaling pathway|
|positive regulation of cysteine-type endopeptidase activity|
|early endosome membrane|
|male sex differentiation|
|regulation of intrinsic apoptotic signaling pathway|
|mitochondrial outer membrane|
|glial cell differentiation|
|positive regulation of endopeptidase activity|
|positive regulation of apoptotic signaling pathway|
|regulation of mitochondrion organization|
|positive regulation of peptidase activity|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|gonad development|
|gliogenesis|
|mitochondrial transport|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|development of primary sexual characteristics|
|negative regulation of apoptotic signaling pathway|
|regulation of cysteine-type endopeptidase activity|
|sex differentiation|
|apoptotic signaling pathway|
|ubiquitin protein ligase binding|
|regulation of neuron death|
|regulation of cytosolic calcium ion concentration|
|regulation of autophagy|
|signaling receptor binding|
|positive regulation of proteolysis|
|negative regulation of organelle organization|
|mitochondrial inner membrane|
|regulation of apoptotic signaling pathway|
|cellular component disassembly|
|regulation of endopeptidase activity|
|reproductive structure development|
|reproductive system development|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|mitochondrion organization|
|regulation of peptidase activity|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|negative regulation of transport|
|protein heterodimerization activity|
|divalent inorganic cation homeostasis|
|protein complex oligomerization|
|cell population proliferation|
|cellular metal ion homeostasis|
|positive regulation of organelle organization|
|metal ion homeostasis|
|cellular cation homeostasis|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|developmental process involved in reproduction|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of proteolysis|
|regulation of cellular response to stress|
|brain development|
|cellular chemical homeostasis|
|positive regulation of hydrolase activity|
|cellular response to DNA damage stimulus|
|head development|
|ion homeostasis|
|regulation of cellular catabolic process|
|membrane organization|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|apoptotic process|
|endoplasmic reticulum membrane|
|central nervous system development|
|Golgi apparatus|
|positive regulation of transport|
|regulation of catabolic process|
|negative regulation of cell death|
|endoplasmic reticulum|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|cell death|
|chemical homeostasis|
|positive regulation of cellular component organization|
|mitochondrion|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of response to stress|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|regulation of transport|
\\
=== CRISPR Data ===
No hits were found.
No correlation found to any other genes in chemogenomics.
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 16141
* **Expression level (log2 read counts)**: -0.32
{{:chemogenomics:nalm6 dist.png?nolink |}}